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11:00 am - 8:00 pm
Registration/Information Desk
PRE-CONFERENCE SESSION: New Horizons in Redox Biology - Redox Metabolism
Separate registration required
Chairs: Carola Neumann, MD, University of Pittsburgh, USA and Yvonne Janssen-Heininger, PhD, University of Vermont, USA
It is well recognized that a close connection exists between redox processes and cellular metabolism – one only has to consider the redox couples NADH/NAD+ and NADPH/NADP+ and their oxidation states during glycolysis and the Krebs cycle. The intersection between redox processes and metabolism is gaining increasing attention in cancer biology and other chronic diseases wherein it has become clear that metabolic reconfiguration is critical to maintain redox homeostasis and resistance to ferroptosis. This session will feature investigators have made seminal insights into the molecular basis for this intersection through the identification of pathways and oxidation targets.
1:00 pm - 1:05 pm
Welcome
1:05 pm - 1:50 pm
How Mitochondria Respond to Changes in Caloric Intake
Alicia J. Kowaltowski, MD, PhD, Universidade de São Paulo, Brazil
1:50 pm - 2:20 pm
Dissecting the Role of Aberrant Redox Metabolism in Lung Cancer
Thales Papagiannokopoulos, PhD, New York University, USA
2:20 pm - 2:50 pm
Redox Signalling in Aging
Helena Cocheme, PhD, Imperial College London, London, UK
2:50 pm - 3:10 pm
Break
3:10 pm - 3:40 pm
Identification of Druggable and Redox Vulnerabilities in Cancer
Liron Bar-Peled, PhD, Mass General Hospital, USA
3:40 pm - 4:10 pm
Glutaredoxin-Mediated Control of GSH: A Thiol Connection with System XC- and Relevance to Lung Cancer
Yvonne Janssen-Heininger, PhD, University of Vermont, USA
ANNUAL CONFERENCE BEGINS
4:45 pm - 4:55 pm
Chairs & President's Welcome
Francisco Laurindo, MD, University of São Paulo, Brazil, SfRBM-SFRRI 2023 Conference Co-Chair
Rafael Radi, MD, PhD, Universidad de la República - Uruguay, SfRBM-SFRRI 2023 Conference Co-Chair
Giovanni Mann, PhD, King's College London, UK, SFRRI President
PLENARY SESSION
4:55 pm - 5:40 pm
Opening Plenary Speaker
Nitrogen Oxide-derived Anti-inflammatory Lipid Signaling Mediators
Bruce Freeman, PhD University of Pittsburgh, USA
5:40 pm - 6:10 pm
SFRRI Trevor Slater Award Lecture
Chairs: Giovanni Mann, PhD, King's College London, UK and Juan Sastre, PhD, University of Valencia, Spain
Deciphering the Enigma of Alpha-tocopherol Regulation
Maret Traber, PhD Oregon State University, USA
6:10 pm - 6:40 pm
SfRBM Discovery Award Lecture
“Dark Matter” Pathways of Protein Transnitrosylation Injure Synapses in Alzheimer’s Disease
Stuart Lipton, MD, PhD, Scripps Research Institute, USA
6:45 pm - 7:30 pm
Welcome Concert / Cultural Event featuring Malena Muyala
7:30 pm - 9:00 pm
Opening Reception
7:00 am - 6:00 pm
Registration/Information Desk
SUNRISE FREE RADICAL SCHOOL: BACK TO BASICS
Chairs: Flavia Meotti, PhD, University of Sao Paulo, Brazil and Matthew Ryan Smith, PhD, Atlanta Veterans Affairs Health Care System, USA
8:00 am - 8:30 am
ABCs of Free Radicals and Reactive Oxygen Species
Eugenio Barone, PharmD, PhD, Sapienza University of Rome, Italy
8:30 am - 9:00 am
Free Radicals in Medicine/Health
Henrik Poulsen, MD, University of Copenhagen, Denmark
PLENARY SESSION
9:00 am - 9:45 am
Plenary Session: Role of Redox-Sensitive RyR Calcium Release Channels in Hippocampal Function in Health & Disease
Cecilia Hidalgo, PhD, Universidad de Chile, Chile
9:45 am - 10:15 am
Break
SYMPOSIA SESSION 1: Omic Science in the Investigation of Redox Processes in Metabolism and Cancer
Chairs: Ralf P. Brandes, MD, Goethe-Univerität, Frankfurt, Germany and Michael Davies, DPhil, University of Copenhagen, Denmark
Reactive oxygen species strongly impact the cellular functional state through changes in metabolism, epigenetics and gene expression. Although numerous redox-sensitive pathway and redox-mechanism have been identified through targeted approaches, this research has to be hypothesis-driven and therefore had to extend established concepts. With the recent expansion of large-scale omics technologies, unbiased methods become available to researchers at large covering the whole spectrum of elements within a cell or an organism. The symposium will highly how this technical expansion enabled identification of novel redox aspects with respect to their contribution to epigenetics in cancer and metabolism.
10:15 am - 10:45 am
Changes in the Native and Modified Proteome of the Artery Wall in Cardiovascular Disease
Michael Davies, DPhil, University of Copenhagen, Denmark
10:45 am - 11:15 am
Redox Control of the Endothelial Glutamine Metabolism
Flavia Rezende, PhD, Goethe-Univerität, Frankfurt, Germany
11:15 am - 11:35 am
Mitochondrial Metabolism After Ischemic Stroke and the Circadian Effects
Amin Mottahedin, University of Oxford, UK
11:35 am - 11:55 am
Plasma oxidized phospholipidome as an indicator of comorbidities in critically ill patients
Clint Upchurch, University of Virginia, USA
SYMPOSIA SESSION 2: Oxidation of Thiols in Biology and Medicine
Chairs: Madia Trujillo, MD, PhD, Universidad de la República, Uruguay and Marcelo Comini, PhD, Institut Pasteur of Montevideo, Uruguay
The symposium will cover novel aspects of redox chemistry and biology of thiols of biomedical interest, with emphasis in novel postranslation modifications of Cys residues and in the molecular mechanisms that link protein Cys oxidations to pathophysiological states and translational medicine.
10:15 am - 10:45 am
The Emerging Role of Coenzyme A and Protein CoAlation in Redox Regulation
Dr. Ivan Gout, University College London, UK
10:45 am - 11:15 am
Role of Peroxiredoxins in the Differentiation of Myeloid Cells
Flavia Meotti, PhD, University of São Paulo, Brazil
11:15 am - 11:35 am
Potential role of peroxiredoxin 6 in supporting mitochondrial function
Jose Pablo Vazquez-Medina, University of California, Berkeley
11:35 am - 11:55 am
TRC40 is a redox-regulated chaperone that protects cells from proteotoxic stress
Bianca Dempsey, Universidade de Sao Paulo, Brazil
SYMPOSIA SESSION 3: Redox Control of Muscle Responses to Exercise: Translation into Benefits for Muscle Health
Chairs: Daniela Caporossi, PhD, University of Rome Foro Italico, Italy and Malcolm J Jackson, PhD, University of Liverpool, UK
Generation of a reactive oxygen species (superoxide) and nitric oxide by contracting skeletal muscle has a specific role in the maintenance of muscle function; Manipulations of skeletal muscle nitric oxide and NADPH oxidases are now recognized to have the potential to preserve diverse physiological functions in various diseases and in aging; The symposium will highlight the latest developments in these areas and provide information on the potential for further redox translational developments to maintain and enhance muscle function in physio-pathological situations.
10:15 am - 10:45 am
Dysregulation of Hydrogen Peroxide-Mediated Responses to Exercise in Aging
Malcolm Jackson, PhD, University of Liverpool UK
10:45 am - 11:15 am
Nitrate-Nitric Oxide and NADPH Oxidase Regulation of Respiratory Muscle Function in Heart Failure and Aging
Leonardo Ferreira, PhD, University of Florida, USA
11:15 am - 11:35 am
Crossroads of Nitric Oxide and Mitochondrial Metabolism: Implications for Skeletal Muscle Adaptations to Exercise
Rebecca Mammel, Virginia Polytechnic and State University, USA
11:35 am - 11:55 am
Role of the Sympathetic Nervous System in Amyotrophic Lateral Sclerosis (ALS)
Lisley Santos Ramalho, University of Sao Paulo, Brazil
12:00 pm - 2:00 pm
Lunch on own - Food available at Convention Center cafeteria
12:00 pm - 1:00 pm
Trainee Council Professional Development Session: Time Management and How to Turn Results into a Story
1:00 pm - 1:45 pm
Professional Development Session 1: Academia, Innovation and Commercialization
Francisco Schopfer, Ph.D., MBA, University of Pittsburgh, USA
Carlos Escande, PhD, Pasteur Institut, Uruguay
12:30 pm - 1:45 pm
Opening Doors Event: Tackling Imposter Syndrome in Academia
This session will address the pervasive issue of imposter syndrome within the academic community. It will feature a series of small group discussions/ working groups, facilitated by committee members and volunteers who can provide valuable perspectives, hindsight, and support. Facilitated groups include Woman-Identifying, Racialized Minority, or LGBTQIA+, Trainees (Graduate Students and Postdocs), Pre-Tenure/Tenure-Track/Early Career Academics and English as a Second Language. The primary goal of this workshop is to create a sense of community and equip participants with strategies to combat imposter syndrome.
SYMPOSIA SESSION 4: NOX Enzymes in Health and Disease - From Structural Biology to Clinical Translation
Chairs: Lucia Lopes, PhD, University of São Paulo, Brazil and Albert van der Vliet, PhD, University of Vermont, USA
NADPH oxidases (NOX) are a family of transmembrane enzymes that mediate regulated and localized production of reactive oxygen species (ROS) for various important biological purposes, ranging from antimicrobial host defense to vascular response to injury. The past decades have witnessed significant advances in our understanding of NOX enzymes in redox signaling and in the development of chronic diseases and has led to a major search and development of specific inhibitors to target them. This symposium will highlight major recent advances in various aspects of NOX biology, ranging from their evolutionary origins and structural diversity to their roles in cell biology and chronic disease and the current status of development of NOX-selective inhibitors for clinical application.
2:00 pm - 2:30 pm
Structural Characterization of Bacterial NAD(P)H Oxidase: Highlighting the Origin and Mechanism of Eukaryotic NOX
Franck Fieschi, PhD, University of Grenoble-Alpes, France
2:30 pm - 3:00 pm
DUOX1 Promotes Profibrotic Macrophage Activation and Pulmonary Fibrosis
Albert van der Vliet, PhD, University of Vermont, USA
3:00 pm - 3:20 pm
A Novel Biomarker for Inflammation: Measuring Reactive Oxygen Species in Immune Cells using Nanoscale MRI
Britt Coenen, University of Groningen, Netherlands
3:20 pm - 3:40 pm
Endoplasmic reticulum - plasma membrane contact sites as a potential hub for Protein Disulfide Isomerase-A1 (PDIA1) / NADPH oxidase cross-talk
Tiphany De Bessa, Heart Institute, University of Sao Paulo, Brazil
SYMPOSIA SESSION 5: Microbial Redox Systems at the Host Pathogen Interface: Potential Targets for New Therapeutic Approaches
Chairs: Luis Netto, PhD, University of São Paulo, Brazil and Andrés Vazquez-Torres, DVM, PhD, University of Colorado, USA
Redox processes play central roles in host pathogen interactions, underlying both inflammatory as well as anti-inflammatory/resolution pathways. Understanding how microbial redox proteins aid pathogenic microorganisms during colonization and infection of humans may provide novel therapeutic opportunities. This symposium will discuss novel cysteine redox sensors that mediate adaptation of bacterial pathogens to oxidative stress and antibiotic killing.
2:00 pm - 2:30 pm
Inhibiting Ohr (Organic Hydroperoxide Resistance Protein): A Unique Antioxidant Protein from Pathogens
Luis Netto, PhD, University of São Paulo, Brazil
2:30 pm - 3:00 pm
Molecular Characterization of a Novel Thiol-Based Sensor of Nitrosative Stress in the Electron Transport Chain
Andrés Vasquez-Torres, DVM, PhD, University of Colorado School of Medicine, USA
3:00 pm - 3:20 pm
Functional insights into PaLsfA: 1-Cys Peroxiredoxin that play key roles in the antioxidant defense of Pseudomonas aeruginosa
Rogerio Aleixo Silva, University of Sao Paulo, Brazil
3:20 pm - 3:40 pm
Protein nitration via iNOS induces collapse of intracellular parasite vacuoles that have been targeted by cell-autonomous immune GTPases
Samantha Lempke, University of Virginia, USA
SYMPOSIA SESSION 6: Metallome and Redox Regulation: Its Systemic Health Effects
Chairs: Young-Mi Go, PhD, Emory University, USA and Christoph Fahrni, PhD, Georgia Institute of Technology, USA
Despite the importance of nutritional trace metals to human health, the molecular mechanisms that relate cellular metal homeostasis and redox balance remain often elusive. This symposium will highlight critical connections between cellular redox regulation, trace metal ion interactions, and environmental metal exposure. Such insights may also pave the way towards preventative strategies to combat diseases associated with metal dysregulation.
2:00 pm - 2:30 pm
Redox Metallomics
Wolfgang Maret, PhD, King's College London, UK
2:30 pm - 3:00 pm
Copper and Cellular Redox Balance in Normal Cell Differentiation and in Disease
Svetlana Lutsenko, PhD, Johns Hopkins University, USA
3:00 pm - 3:20 pm
Dmo2p is a neglected protein required for the proper function of copper dependent enzymes Sod1p and Cox2p
Maria Antonia K. M. Soares, University of Sao Paulo, Brazil
3:20 pm - 3:40 pm
Phytochelatin 2, a Glutathione Oligomer, Interacts With Selenium and Cadmium Disposition
Zachery Jarrell, Emory University, USA
3:45 pm - 5:45 pm
Formal Poster Presentations
6:00 pm - 7:00 pm
FRBM and Redox Biology Editorial Board Meeting
7:00 pm - 8:00 pm
Elsevier Redox Journals Editors and Editorial Board Members Joint Reception (by invitation)
7:00 am - 6:00 pm
Registration/Information Desk
SUNRISE FREE RADICAL SCHOOL: BACK TO BASICS
Chairs: Flavia Meotti, PhD, University of Sao Paulo, Brazil and Matthew Ryan Smith, PhD, Atlanta Veterans Affairs Health Care System, USA
8:00 am - 8:30 am
Current Methods for the Detection of Free Radicals and Reactive Oxygen Species
Jacek Zielonka, PhD, DSc, Medical College of Wisconsin, USA
8:30 am - 9:00 am
Antioxidants and Antioxidant Systems
Alicia Timme-Laragy, PhD, University of Massachusetts Amherst, USA
PLENARY SESSION
9:00 am - 9:45 am
Plenary Session: Krebs Cycle Reprogrammed in Immunity and Inflammation
Luke O'Neill, Trinity College, Dublin
9:45 am - 10:15 am
Break
SYMPOSIA SESSION 7: Probing Cardiovascular and Neurodegenerative Disease Pathway Using Redox Chemogenetics
Chairs: Thomas Michel, MD, PhD, Harvard Medical School, Brigham and Women’s Hospital, USA and Helmut Sies, MD, Heinrich Heine University, Dusseldorf, Germany
Chemogenetic approaches have revolutionized the “redox toolbox”. Novel transgenic chemogenetic mouse lines and recombinant viral constructs have recently been developed to dynamically modulate hydrogen peroxide levels in specific tissues in vivo. This Symposium will present recent discoveries using chemogenetic approaches that are providing unexpected insights into the roles of redox stress in cardiovascular and neurodegenerative disease states.
10:15 am - 10:45 am
Sensory Ataxia and Cardiac Hypertrophy Caused by Neurovascular Oxidative Stress
Thomas Michel, MD, PhD, Harvard Medical School, Brigham and Women's Hospital, USA
10:45 am - 11:15 am
Chemogenetic Intraneuronal Oxidative Stress Affects Synaptic Plasticity
Vsevolod Belousov, PhD, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russia
11:15 am - 11:35 am
ApoE isoforms alter glial Nrf2 activation, and antioxidant levels and oxidative damage in cerebral cortex of mice and humans
Max Thorwald, University of Southern California, USA
11:35 am - 11:55 am
Intracellular Delivery of CxxCpep, a Protein Disulfide Isomerase Targeted Peptide, As a New Strategy to Inhibit Vascular Smooth Muscle Cell Migration.
Antonio Marcus Paes, Federal University of Maranhao, Brazil
SYMPOSIA SESSION 8: The Many Faces of Hydrogen Sulfide and its Derivatives
Chairs: Beatriz Alvarez, PhD, Universidad de la República, Uruguay and Gustavo Salinas, PhD, Institut Pasteur de Montevideo and Universidad de la República, Uruguay
The molecular mechanisms underlying the effects of H2S and H2S derivatives such as persulfides (RSSH/RSS-) in biological systems have begun to be unraveled. This session will provide an updated view of H2S-triggered processes, with a special focus on signaling in mitochondria and the keys to persulfidation. The molecular basis of the biological outcomes related to H2S and redox homeostasis will be emphasized.
10:15 am - 10:45 am
A Mitochondrial Perspective on Sulfide Signaling
Ruma Banerjee, PhD, University of Michigan Medical School, USA
10:45 am - 11:15 am
RIPS-1 is a Novel Methyltransferase That Acts Independently of Sulfide Detoxification Pathways to Promote Tolerance to H2S in C. Elegans
Dana Miller, PhD, University of Washington, USA
11:15 am - 11:35 am
E2/E3-independent ubiquitin-like protein conjugation by Urm1 is coupled to cysteine persulfidation and protects the proteome under oxidative stress
Keerthiraju Ethiraju Ravichandran, Chester Beatty Laboratories, United Kingdom
11:35 am - 11:55 am
Increased intracellular persulfide levels attenuate HlyU-mediated hemolysin transcriptional activation in Vibrio cholerae
Daiana Capdevila, Fundacion Instituto Leloir, Argentina
SYMPOSIA SESSION 9: RNA Translation and Redox Biology
Chairs: Nadine Hempel, PhD, University of Pittsburgh, USA and Elena Piskounova, PhD, Weill Cornell School of Medicine, USA
Description: An imbalance in redox homeostasis requires immediate cellular responses to evade deleterious consequences of oxidative stress. RNA translation can initiate rapid changes in protein expression, allowing cells to promptly adapt to environmental and cellular stress. In this session we will highlight how RNA modifications, RNA binding proteins and the translation machinery are altered in the context of disease and in response to environmental stress; and illustrate how this allows cells to maintain redox homeostasis by manipulation of the cells’ antioxidant enzyme systems.
10:15 am - 10:45 am
tRNA is a Dynamic Regulator of Gene Expression in Response to Stress
Thomas Begley, PhD, University at Albany, The RNA Institute, USA
10:45 am - 11:15 am
Role of tRNA Wobble Uridine Modifications in Oxidative Stress Resistance and Metastasis
Elena Piskounova, PhD, Weill Cornell Medicine, USA
11:15 am - 11:35 am
Annotation, Diversity and Evolution of Selenocysteine-containing Oxidoreductases in Eukaryotes
Marco Mariotti, Universitat de Barcelona, Spain
11:35 am - 11:55 am
Disturbed flow regulates protein disulfide isomerase A1 expression via microRNA-204 and controls vascular smooth muscle cell differentiation
Lucas Gutierre, University of Sao Paulo, Brazil
12:00 pm - 2:00 pm
Lunch on own - Food available at Convention Center cafeteria
1:00 pm - 1:45 pm
Professional Development Session 2: How to become a Principal Investigator in the US, Europe and Latin America
Edward Moreira Bahnson, Ph.D., University of North Carolina at Chapel Hill, USA, Andres Trostchansky, Ph.D. Facultad de Medicina - PEDECIBA, Universidad de la República, Uruguay and Rebecca Charles PhD, Queen Mary University of London, UK
SYMPOSIA SESSION 10: Mechanisms and Translation of Platelet Redox Signaling in Health & Diseases
Chairs: Eva Nozik, MD, University of Colorado, USA and Sruti Shiva, PhD, University of Pittsburgh, USA
Platelets, once viewed as small anucleate cell fractions that only play a role in thrombosis, are now recognized as key sentinel and effector cells that bridge hemostatic, thrombotic, inflammatory, and immune processes in both health and disease. Notably, redox mechanisms play a critical role in modulating platelet function. This session focuses on the most recent advances examining mechanistic platelet redox signaling mechanisms and their translation to human physiology and disease.
2:00 pm - 2:30 pm
Redox Regulation of Platelet Activation and Thrombosis in Aging
Sanjana Dayal, PhD, University of Iowa, USA
2:30 pm - 3:00 pm
Role of Platelet-Derived Extracellular Vesicles and their Mitochondrial Content in Inflammation
Eric Boilard, PhD, University Laval, Canada
3:00 pm - 3:20 pm
Metabolic Dysregulation in Group 3 Pulmonary Hypertension
Matthew Ryan Smith, Emory University, USA
3:20 pm - 3:40 pm
Protein Disulphide Isomerase A1 binds to fibrillar type I collagen and regulates its fibrillogenesis
Renato Gaspar, University of Sao Paulo, Brazil
SYMPOSIA SESSION 11: Lipid Electrophiles and Metabolism in Redox Inflammatory Signaling
Chairs: Homero Rubbo, PhD, Universidad de la República, Uruguay and Francisco Schopfer, PhD, University of Pittsburgh, USA
This session discusses recent advances in electrophilic-mediated intracellular signaling, including lipidomic, oxylipins, and specialized pro-resolving lipid mediators (SPMs) detection and biological roles in human pathology.
2:00 pm - 2:30 pm
The Effects of Reactive Oxidized Lipid Adducts on PTEN Structure, Activity and Cell Signaling
Corinne Spickett, PhD, Aston University, UK
2:30 pm - 3:00 pm
Electrophilic Fatty Acids Modulate Immune Cell Function by Targeting Key Inflammatory Enzymes
Andrés Trostchansky, PhD, Universidad de la República, Uruguay
3:00 pm - 3:20 pm
Conjugated linoleic acid esterified to phosphatidylcholine is a substrate for nitration and adaptive signaling in activated RAW264.7 macrophages
Nicole Colussi, University of Pittsburgh, USA
3:20 pm - 3:40 pm
Spatial-temporal detection of lipoperoxides with a genetically encoded biosensor targeted to different sub-cellular regions
Natalia Oddone, Institut Pasteur de Montevideo, Uruguay
SYMPOSIA SESSION 12: Redox Mechanisms of Cancer Cell Fate Decisions
Chairs: Carola Neumann, MD, University of Pittsburgh, USA and Marcelo Bonini, PhD, Northwestern University, USA
Redox homeostasis and metabolic pathways are intrinsically involved in regulating gene transcription networks accounting for cell fate of cancer cells. This session will cover multidisciplinary strategies addressing mechanisms of cancer cell fate decisions, including novel modalities of cell death, with potential implications in precision cancer medicine. Attendees will gain an integrative understanding about how such basic molecular and biochemical mechanisms may extend to novel therapeutic interventions.
2:00 pm - 2:30 pm
Targeting Disulfidptosis as a Redox Vulnerability in Cancer
Boyi Gan, PhD, The University of Texas MD Anderson Cancer Center, USA
2:30 pm - 3:00 pm
Canonical Histone Oxidation Drives Redox-Dependent Reprogramming of the Cancer Cell Transcriptome
Marcelo Bonini, PhD, Northwestern University, USA
3:00 pm - 3:20 pm
Adipose Tissue is Prone to Radiation Damage, Reducing Adiponectin Secretion and Subsequent Radioprotection of Healthy Tissue
Joshua A. McDowell, University of Nebraska Medical Center
3:20 pm - 3:40 pm
Peroxiredoxin 1 phosphorylation is a critical signaling event in Triple Negative Breast Cancer-associated fibroblasts
Lisa Hong, University of Pittsburgh, USA
3:45 pm - 5:45 pm
Formal Poster Presentation
7:00 am - 6:00 pm
Registration/Information Desk
SUNRISE FREE RADICAL SCHOOL: BACK TO BASICS
Chairs: Flavia Meotti, PhD, University of Sao Paulo, Brazil and Matthew Ryan Smith, PhD, Atlanta Veterans Affairs Health Care System, USA
8:00 am - 8:30 am
Thiol Protein Reactivity and Mechanisms of Redox Signaling
Christine Winterbourn, PhD, University of Otago Christchurch, New Zealand
8:30 am - 9:00 am
Mitochondrial Metabolism and Signaling
Nadine Hempel, PhD, University of Pittsburgh, USA
PLENARY SESSION
9:00 am - 9:30 am
SFRRI Alberto Boveris Award Lecture
Chairs: Enrique Cadenas, MD, Ph.D, University of Southern California, USA & Ohara Augusto, Ph.D, University of São Paulo, Brazil
Intracellular and Extracellular Redox Communication
Helmut Sies, MD, University of Düsseldorf, Germany
9:30 am - 10:00 am
SFRRI Lester Packer Award Lecture
Chairs: Patricia Oteiza, Ph.D., University of California, Davis, USA & Kelvin Davies, University of Southern California, USA
Free Radicals in Alzheimer’s Disease: From Pathophysiology to Clinical Trial Results
Jose Vina, MD, Ph.D., University of Valencia, Spain
10:00 am - 10:30 am
Break
SYMPOSIA SESSION 13: Bench to Bedside Translation for Pharmacological Regulation of NRF2
Chairs: Giovanni Mann, PhD, King’s College London, UK and Henry Forman, University of Southern California, USA
NRF2 (Nuclear factor erythroid 2-related factor 2) is a key transcription factor for regulation of cellular redox homeostasis, activating genes that participate in the protection against oxidative, inflammatory, metabolic and proteotoxic stress. Given the impact of NRF2 in physiology and pathology, it is not surprising that it has attracted a significant attention by the biomedical community. Contrary to most transcription factors, NRF2 is amenable to pharmacological activation by selectively inhibiting its degradation. This symposium highlights recent research in the development of activators and inhibitors of NRF2 to improve clinical translation.
10:30 am - 11:00 am
Development of Therapeutics to Target the "Dark Side" of NRF2
Donna Zhang, PhD, University of Arizona, USA
11:00 am - 11:30 am
Activators and Inhibitors of NRF2 and their Potential for Clinical Translation
Antonio Cuadrado, PhD, Autonomous University of Madrid (UAM), Spain
11:30 am - 11:50 am
The activation of Nrf2 pathway prevents neurodegenerative damage induced by hippocampal expression of caspase-3 cleaved tau
Rodrigo A. Quintanilla, Universidad Autonoma de Chile, Chile
11:50 am - 12:10 pm
Unlocking the Power of GSK-3α Inhibitors: How They Counteract LPS-Triggered Inflammation in RAW 264.7 Cells
Anwar Abdelnaser, The American University in Cairo, Egypt
SYMPOSIA SESSION 14: The NAPDP)+/NAD(P)H Redox Couples as Drivers of Metabolism, Signaling and Disease
Chairs: Jan Riemer, Dr. sc (ETH), University of Cologne, Germany and Bruce Morgan, PhD, Saarland University, Germany
The pyridine nucleotide redox couples, NADH/NAD+ and NADPH/NADP+, are central to cellular metabolism in all living organisms. In recent years, novel tools and methodologies have led to exciting new discoveries and have shown us that there is still much to learn about these fascinating cellular metabolites. The speakers of this session will present novel developments in genetically encoded tool and sensor design as well as novel insights into the role of NAD(P)H in physiology and disease.
10:30 am - 11:00 am
Expanding the Set of Genetically Encoded Tools for Compartment-Specific Manipulation of Redox Metabolism in Living Cells
Valentin Cracan, PhD, The Scintillon Institute, USA
11:00 am - 11:30 am
Novel Genetically Encoded NADP+/NADPH Sensors Reveal Surprising New Insights into Subcellular Pyridine Nucleotide Homeostasis
Bruce Morgan, PhD, Universität des Saarlandes, Germany
11:30 am - 11:50 am
Modulation of mitochondrial activity in keratinocytes by uva and visible-light
Manuel Alejandro Herrera Lopez, Universidade de Sao Paulo, Brazil
11:50 am - 12:10 pm
Pharmacological restoration of NAD+/NADH prevents chronic neurodegeneration and neuropsychiatric impairment after whole-brain radiotherapy.
Edwin Vazquez-Rosa, Case Western Reserve University, USA
SYMPOSIA SESSION 15: Redox Mechanisms and Systems Biology: Building an Atlas of the Redox Highways
Chairs: Matthew Ryan Smith, MSc, PhD, Atlanta Veterans Affairs Health Care System, USA and Jianhua Zhang, PhD, University of Alabama at Birmingham, USA
Recent advances in the field of systems-level biology and network medicine have led to many new discoveries in the pathogenesis of disease. Application of these tools to the realm of metabolic and redox biology is a critical need so that we can fully understand the complexity of disease onset and to develop new paradigms to correct these perturbations. This session will emphasize the latest research and software advances that advance the field of redox network biology, ultimately increasing our knowledge of the multi-layered pathogenic matrices in biology.
10:30 am - 11:00 am
Integrative Deep-Profiling of Thiol Redox Proteome and Phosphoproteome for Deciphering Signaling Networks
Wei-Jun Qian, PhD, Pacific Northwest National Laboratory, USA
11:00 am - 11:30 am
Heterogeneity of Single Cell Redox Networks in Head and Neck Cancer
Melissa Kemp, PhD, Georgia Institute of Technology, USA
11:30 am - 11:50 am
APE1/Ref-1 is a Novel Redox-Sensitive Element of Lipopolysaccharide-Induced NF-κB-dependent Inflammatory Response in a Cellular Model of Acute Lung Injury
David Caraballo, Florida International University, USA
11:50 am - 12:10 pm
Regulation of hepatic lysine N-acetylation facilitated by cysteine proximity due to alcohol toxicity
Courtney McGinnis, University of Colorado - Anschutz Medical Campus, USA
12:30 pm - 2:00 pm
Lunch on own - Food available at Convention Center cafeteria
1:00 pm - 1:45 pm
Professional Development Session 3: Transitioning to Industry
Florencia Sardi, Head of R&D at Virbac
SYMPOSIA SESSION 16: Microbial Redox Biology
Chairs: Mehmet Berkmen, PhD, New England Biolabs, USA and Bruno Manta, PhD, Institut Pasteur Montevideo & Universidad de la República, Uruguay
Microbes play a fundamental role in the biochemical reactions of mostly every ecosystem and thus offer tremendous potential to uncover biological processes that are recalcitrant to discovery in more complex systems. This is particularly relevant for redox biology as many fundamental processes were discovered in microbes, opening the path to study them in cell lines and animal models. This session will feature speakers highlighting the unique redox biology of certain microbes and protozoa with an understanding their unique redox machinery will lead to the discovery of drugs to treat diseases.
2:00 pm - 2:30 pm
Protecting Nascent Polypeptides from Premature Aging
Jean-François Collet, PhD, Duve Institute, Belgium
2:30 pm - 3:00 pm
Brace for Survival: How Bacteria Fold Proteins Essential for Virulence and Fitness
Begoña Heras, PhD, La Trobe University, Australia
3:00 pm - 3:20 pm
Biochemical and Structural Analysis of Peroxiredoxins from Aspergillus fumigatus
Maria Tereza Oliveira Batista, University of Sao Paulo, Brazil
3:20 pm - 3:40 pm
Sensitising Streptococcus pneumoniae to the Immune-Derived Oxidant Hypothiocyanous Acid
Heather Shearer, University of Otago, New Zealand
SYMPOSIA SESSION 17: Compartmentalized Redox Signaling in Crowded Cells
Chairs: Roberto Sitia, MD, Università Vita-Salute Ospedale San Raffaele, Italy and Elena Hidalgo, PhD, Universitat Pompeu Fabra, Spain
Description: In all domains of life, specialized aquaporins bidirectionally transport H2O2 across membranes and facilitate peroxide transport through lipid barriers, controlling redox signals in space, time and intensity. Fluorescence biosensors allow to investigate the dynamics of H2O2 fluxes in living cells and across membranes. This symposium will present some of the recent methodological and conceptual advances in the compartmental regulation of redox signals.
2:00 pm - 2:30 pm
Control of Redox Signaling by Organelle Specific Peroxiporins
Roberto Sitia, MD, Università Vita-Salute Ospedale San Raffaele, Italy
2:30 pm - 3:00 pm
Role of Peroxiredoxins and Peroxiporins in Mitochondrial-to-Cytosol H2O2 Gradients and Signaling
Elena Hidalgo, PhD, Univeritat Pompeu Fabra, Spain
3:00 pm - 3:20 pm
Crowded environments as modulators of oxidation reactions: Effects on the modification and aggregation of key metabolic and digestive enzymes
Eduardo Fuentes-Lemus, University of Copenhagen, Denmark
3:20 pm - 3:40 pm
Proteome-wide Tagging With Genetically Encoded Biosensors To Identify Highly Localised Oxidation Events
Paraskevi Kritsiligkou, German Cancer Research Center (DKFZ), Germany
SYMPOSIA SESSION 18: Post-translational Redox Modifications of Proteins in Inflammatory Signaling: S-Nitrosylation and S-Persulfidation
Chairs: Andrew Pieper, MD, PhD, Western Reserve University, USA and Stuart Lipton, Scripps Research Institute, USA
Cysteine S-nitrosylation and persulfidation are important posttranslational modifications involved in diverse physiological and pathological processes. This symposium will discuss recent progress in our understanding of how aberrant protein S-nitrosylation contributes to neuroinflammation and Alzheimer's disease pathogenesis. The symposium will also present new findings about protective effects of protein persulfidation in inflammatory-oxidative responses.
2:00 pm - 2:30 pm
Dysregulated Persulfidation and Nitrosylation-mediated Signaling in Huntington's and Alzheimer's Disease
Bindu Paul, PhD, John Hopkins School of Medicine, USA
2:30 pm - 3:00 pm
Widespread Cysteine Persulfidation in Activated Macrophages as a Protective Mechanism Against Oxidative-Inflammatory Stress
Moran Benhar, PhD, Technion-Israel Institute of Technology, Israel
3:00 pm - 3:20 pm
MitoPerSulf: Mitochondrial-Targeted Protection Against Cardiac Ischemia-Reperfusion via Rapid Persulfide and H2S Release
Jan Miljkovic, University of Cambridge, UK
3:20 pm - 3:40 pm
Structural and Functional Consequences of Tyrosine Nitration in the Hsp90 Chaperone
Alfonso Taboada, Universidad de la República, Uruguay
3:45 pm - 5:45 pm
Formal Poster Presentation
6:15 pm - 7:45 pm
Closing Banquet & Awards Ceremony
SfRBM-SFRRI 2023 officially adjourns after the Closing Awards Banquet on Saturday, November 18.
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