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In Memoriam: Robin L. Willson

It is with great sadness that we announce the passing of one of the ‘founding fathers’ of the free radical and redox fields, Professor Robin Linhope Willson. He died peacefully at his home in Puerto Madryn, Patagonia, Argentina, where he had lived since retiring from Brunel University. He was 81 and leaves behind a wife Vicky, and two children, Emma and Suzy, from his first marriage to Hester Bowen who died in 1996.

In thinking about what highlights to include of the many discoveries associated with Robin Willson, and particularly those of the widest and most-enduring interest to the field of free radical chemistry and biology, the direct observation of the ‘repair’ of radicals formed from the antioxidants, vitamin E and thiols, by ascorbate (vitamin C) immediately springs to mind (Willson 1983a, 1983b). These observations were reported in a paper with John Packer and Trevor Slater in Nature in 1979 (Packer et al. 1979) and is Robin’s most cited work (~2000 citations). However, glancing through the list of Robin’s publications presents a great problem: where to start? This is because Robin led the way in so many different areas, and not just as a scientist, but also as a communicator, educator and inspiration behind the ‘Magic Pennies’ project, which opened the eyes of many children and young adults to the field of magnetism.

Robin was born in 1941 in Lytham St Annes, Lancashire, and his scientific career began as a radiation chemist in the mid-1960s in the laboratory of ‘Joe’ Weiss (of Haber-Weiss fame) at the University of Newcastle, UK, after having completed his undergraduate training at King’s College, Durham University. Joe Weiss had, more or less, invented the field of radiation chemistry of biomolecules with his paper in Nature in 1944. With George Scholes, Elie Hayon, Gabriel Stein and Alastair Johnson, the Newcastle group ‘spawned’ a large number of the radiation chemists who went on to have a major international impact in free-radical and radiation biology, including John Ward, Les Redpath and, of course, Robin. The Newcastle group focused on reactions of radicals produced on radiolysis of aqueous solutions of nucleic acids, and Robin’s first papers were in this area; he was awarded his PhD in 1966.

After the Cortina International Congress of Radiation Research in 1966, Robin took up a postdoc with Larry Myers at the Laboratory of Nuclear Medicine and Radiation Biology, University of California Los Angeles. While there, he played a major role in developing a nanosecond pulse radiolysis facility at General Atomics, San Diego (Theard et al. 1967). He also initiated the use of an early programmable Olivetti calculator for handling the data.    


After his post-doctoral position in California, Robin was recruited by Ged Adams to strengthen the radiation chemistry group in the Gray Laboratory at Mount Vernon Hospital, Northwood, near London. In 1960, radiation chemistry was revolutionized by the development of kinetic spectrophotometry methods that allowed direct observation and monitoring of radiation-chemical intermediates following short (microsecond) pulses of radiation; the laboratory founded by L.H. Gray was a pioneer in this technique, and  in his early years there Robin characterized key reactions relevant to radiation biology. The hydrated electron had been observed directly at Mount Vernon by Ed Hart and Jack Boag in 1962, and Robin’s observations of single electron transfer reactions between molecules of differing electron affinity led the way to a detailed and quantitative understanding of redox reactions involving free radicals (Willson 1970a, 1970b, 1971; Patel and Willson 1973; Forni and Willson 1984). Not least of these was the realization that superoxide radicals (O2•–) could be formed as a consequence of radical ‘repair’ by thiols (RSH) (Adams et al. 1969), the thiyl radicals (RS) forming disulphide radical-anions, that in turn reduced molecular oxygen to O2•–:

            free radical + RSH -->> ‘repaired’ species + RS

            RS + RS (RSSR)•–

            (RSSR)•– + O2 ®--> RSSR + O2•–.

This reaction has been subsequently shown to be ubiquitous and a critical process in biological systems.

Other examples of Robin’s work at Mount Vernon included work on the reactions of nucleic acids with hydroxyl (HO) and other radicals (Willson 1970c), and later work on radical damage to proteins and enzymes (Adams et al. 1972). The involvement of ascorbate in free-radical biology was a theme running through much of Robin’s career, and at Mount Vernon he published, with Les Redpath, important work revealing how ascorbate reacted with oxidizing radicals and its effects on radiosensitivity (Redpath and Willson 1973).

Robin also contributed significantly to the development of the use of ‘electron-affinic’ radiosensitizers to kill hypoxic cells (the radiation resistance of such populations of tumour cells is a common cause of the failure of radiotherapy to eradicate tumours). In particular, a prototypic nitroaromatic compound was shown by Adams, Robin, and colleagues to have efficacy in this regard (Adams et al. 1971). Robin, working with Lance Foster, gave the field a huge boost by demonstrating radiosensitization by another nitro compound, metronidazole, which was already in widespread clinical use against anaerobic infections (Foster and Willson 1973). Robin’s interest in the redox chemistry of metronidazole, iron and thiols (Willson and Searle 1975; Bahnemann et al. 1978; Searle and Willson 1983) can, with hindsight, be seen to be a precursor (at least in part) to the concept of hypoxia-selective cytotoxins (Foster et al. 1976).

Robin moved in 1973 to Brunel University, a few miles from Mount Vernon, to join Trevor Slater (in the Department of Biochemistry) who already had major interests and a widespread network of collaborators working on free-radical induced lipid peroxidation (see photo below from 1978 taken at Brunel University, with Robin at top right, and Trevor Slater in the middle of the front row). Robin obtained a linear accelerator from Mount Vernon, and set up a pulse radiolysis facility at Brunel. The subsequent years coincided with an explosion of interest in free radicals in biology generally, and Robin’s contributions expanded rapidly to include major contributions to diverse areas of free radical chemistry and biology. He enjoyed a fruitful collaboration with Klaus-Dieter Asmus of the Hahn-Meitner Institut, Berlin, demonstrating radical ‘repair’ of guanine radicals by thiols and phenothiazines (Willson et al. 1974) and later focusing on thiyl and related radicals (Bahnemann et al. 1983a; Mönig et al. 1987). Robin rapidly became recognised internationally as an expert in sulphur radical chemistry (Dunster and Willson 1990).


At Mount Vernon, Robin had studied oxidation of proteins and enzymes by free radicals (Adams et al. 1972) and his interest widened at Brunel, extending studies to oxidation reactions driven by NO2 (Forni et al. 1986), which later become of considerable interest in the context of the effects of peroxynitrite decomposition. Robin introduced useful reagents, including the now widely used oxidant probe ABTS, to monitor oxidizing radicals and also contributed to our understanding of the biochemistry of phenothiazines (Bahnemann et al. 1980, 1983b, 1983a; Forni et al. 1988). His interest in antioxidants extended beyond thiols and ascorbate: thus Robin demonstrated a dramatic difference in the protective effects on radiation-induced inactivation of alcohol dehydrogenase by ascorbate and urate, possibly associated with the formation of a urate peroxyl radical (Kittridge and Willson 1984).

Focusing solely on scientific papers as Robin’s only legacy, no matter how seminal or highly-cited, would be a mistake. In the wider context, his importance as the key driver in the formation of the Society for Free Radical Research – the major scientific organisation devoted to free radical and oxidant research – cannot be overemphasized. Robin’s contribution to the development of the Society is well-documented (https://www.sfrr-europe.org/index.php/sfrre/history) and it is unlikely that the Society would have developed and been as successful as it has been, without his enormous efforts in its early years. In 1982, he organised a survey to determine whether there was national and international interest in ‘an interdisciplinary group to promote discussion amongst chemists, biologists and the medical profession of free radical processes of industrial and medical importance’. The resulting strong and positive response resulted in the formation of an informal society (initially called the ‘Antioxidant Society’) on 1 April 1982. Following further discussions, including an open meeting at the CIBA Foundation, a decision was made to develop an international society that was independent of traditional chemistry or biochemical societies, with the inaugural meeting held at the Royal Institution on 9 July 1982. A subsequent meeting held at Brunel University, organised by Robin and Trevor Slater, led to the adoption of the name ‘Society for Free Radical Research’, the development of its logo, and the society Constitution. From these beginnings, the various partner societies that make up the umbrella organisation – the ‘Society for Free Radical Research – International’ have developed: the Societies for Free Radical Research of Europe, Asia, Australasia and Africa, and the Society for Redox Biology and Medicine in the Americas.
 

In addition to directing the Brunel Biochemistry Linear Accelerator Radiation facility, Robin played a very active role in driving the development of Biochemistry at Brunel, serving as head of Department between 1984-1987, as a leader in the development of world-wide-web services at the University and as a co-founder (with Maurice Kogan and Patrick Riley) of the National Conference of University Professors.

As a committed and enthusiastic lecturer and educator, Robin gave many school and public lectures and media interviews related to medicine, nutrition, radiation and the environment. He also had many wider educational interests beyond the field of free radical research, with these being particularly  reflected in the ’Magic Penny Society’ (http://www.magicpenny.org/engsociety2.htm) which he established to help demonstrate magnetism in a fun way. This led to the development of the Magic Penny Magnet kit, which was launched at Brunel in November 1995. This kit (sponsored by Brunel, the Institute of Physics and the Royal Institution, and illustrated below) is now into its 4th edition, and is particularly popular in USA. A scientific paper describing how magnetic coins and specially designed magnets can be used in mathematical studies of circle packing was published in 2015 to widespread acclaim. This led the former Vice-Chancellor of Brunel University, Michael Stirling, to state that “it will be for his work with Magic Pennies that Robin might one day be most remembered”. The charitable foundation (The Magic Penny Trust) sponsored grants to many deserving educational charities (totaling over £50,000 (US$60,000) over a twenty-year period. 


Robin’s involvement with the National Conference of University Professors led to a visit to Argentina, where he helped teach courses on free radicals organized at the Universidad de Buenos Aires. Argentina, by Alberto Boveris in the 1980s and 1990s. He was to meet his second wife there, and when he retired from Brunel University in 1997 he moved to Patagonia, where he continued working in Ciencias y Artes on educational projects related to astronomy and exploration, until his activities were curtailed by a diagnosis of motor neuron disease. This illness did not diminish his enthusiasm for science, and he continued discussions with colleagues until the disease was highly advanced.

This short description of Robin’s diverse contributions to radiation- and free-radical chemistry and biology has only skimmed the surface. Few scientists in free radical research have had such a broad impact across so many areas, yet at the same time making such seminal discoveries that one cannot write for long about any single topic in this wide area without encountering and exploiting the insights Robin contributed to. His enthusiasm, insight and knowledge will stay with us for many years to come.


Michael J. Davies
Kelvin J.A. Davies
Barry Halliwell
Malcolm J. Jackson
Giovanni E. Mann
Giuseppe Poli
Rafael Radi
Patrick A. Riley
Helmut Sies
John F. Ward
Peter Wardman
John Willson

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Ohara Augusto Selected as Lifetime Achievement Award Recipient

SfRBM's Senior Awards Committee has announced that the recipient of the 2022 Lifetime Achievement Award is Ohara Augusto, PhD of the University of São Paulo. 

Read more »

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SfRBM 2021 Conference to be Delivered Virtually

After careful consideration and member input, the SfRBM Council has made the decision to move to a completely virtual Annual Conference, to be held November 15-18.

Our reasons for cancelling the in-person component in Savannah, Georgia are two-fold:

  • Health & Safety of Our Members – With COVID cases remaining high and many universities and employers enacting travel restrictions or not recommending travel, we want to keep you and your families safe and healthy, doing our part to stop the spread of COVID and burden on healthcare workers.
     
  • Quality In-Person Conference Programming – Over the past few weeks, it became apparent that SfRBM would not be able to produce a quality in-person event that our members have come to expect. The survey we recently sent indicated that the vast majority of members were not planning to attend in-person.

Please be patient with us as we work through additional details. We wanted to share this decision with you as soon as possible. We will still have live virtual sessions Monday, November 15 – Thursday, November 18, and the schedule will be similar to the current program.   SfRBM will circulate more information when it is available.


Sincerely,

Holly Van Remmen, Ph.D.
Oklahoma Medical Research Foundation
SfRBM President

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Batinic-Haberle Selected as Discovery Award Recipient

SfRBM's Senior Awards Committee has announced that the recipient of the 2021 Discovery Award Dr. Ines Batinic-Haberle of Duke University School of Medicine. She is being recognized for her significant contributions to redox chemistry with her potent "SOD mimics" molecules.

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SfRBM - SFRRI Conference in South America Moved to 2023

Dear SfRBM Members & Redox Biology researchers worldwide:

Please be advised that, due to the lingering impact of the pandemic and knowing it will probably take longer than anticipated for travel to return to normal around the world, SfRBM and SFRRI will be delaying our scheduled joint conference in Punta del Este, Uruguay from November 2022 to November 2023.   

Francisco Laurindo (University of São Paulo - Brazil), SfRBM’s current President-Elect, will be the Program Co-Chair along with Rafael Radi (Universidad de la República - Uruguay).

The dates/locations for our 2022 and 2023 conferences will be as follows:

SfRBM 2022
November 16–19, 2022
29th Annual Conference of the Society for Redox Biology & Medicine
Hilton Orlando Buena Vista Palace
Orlando, Florida, USA

SfRBM - SFRRI 2023
November 15–18, 2023
29th Annual Conference of the Society for Redox Biology & Medicine &
SFRRI 21st Biennial Meeting
Punta del Este Convention & Exhibition Center
Punta del Este, Uruguay

We look forward to your participation in these important conferences.

Sincerely,

Holly Van Remmen, Ph.D.
Oklahoma Medical Research Foundation
SfRBM President

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SfRBM and SFRR-E Launch Advances in Redox Research Journal

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Poulsen Selected 2020 Lifetime Achievement Award Recipient

SfRBM's Senior Awards Committee has announced that the recipient of the 2020 Lifetime Achievement Award is Henrik Poulsen, MD of the University of Copenhagen in Denmark.

Dr. Poulsen is being recognized for his comprehensive and long-term achievement in the translation of the basic aspect of oxidative stress into human diseases and their treatments.

Poulsen is a National Board of Health-certified Clinical Pharmacologist and Professor in Clinical Pharmacology with over 10,000+ citations of his work. He received a Medical Doctorate from the University of Copenhagen in 1978 followed by an eventual professorship to build programs in human toxicology and environmental medicine, which resulted in the establishment of the Institute of Environmental Health at the University of Copenhagen.

Since the early 1990's, Poulsen's research interests have been in pharmacogenetics, pharmacoepidemiology, and oxidative stress damage to nucleic acids. He has pioneered the development of a state-of-the-art methodology to non-invasively measure the effects of oxidative stress on DNA and RNA and have used this in molecular epidemiology. His group’s major achievement has been finding an association between RNA oxidation, death and death from cardiovascular disease, in patients with type 2 diabetes, in patients with severe psychiatric disease and recently also in the general population.

He has been involved in the creation of a database that includes data on biochemical measurements, DNA and RNA oxidation, detailed questionnaires, vital status, hospitals admission and diagnoses, social and economic data, daylight variations, and all drug prescriptions, in almost 20,000 people. The biochemical measures now also include GWAS data from high density SNP analysis, and present efforts are to identify genes of relation to oxidation of RNA and DNA, and to extend these findings to their relation to death and death from cardiovascular disease in the cohorts. Inclusion of microbiome data is in the pipeline.

Dr. Poulsen will give a featured lecture during SfRBM's 27th Annual Conference titled, "A Lifetime With DNA and RNA Oxidation," which will be available virtually. Click here to learn more about Dr. Poulsen and his work.

SfRBM congratulates Dr. Poulsen on this highly deserved honor.

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SfRBM Statement on Recent Racialized Events in US

The recent senseless killings of George Floyd, Breonna Taylor, and Ahmaud Arbery have been emotionally overwhelming and traumatic. These deaths, along with the history of racial injustice and brutality against Black people, are stark reminders that racism continues to function in our society.  

To our colleagues, faculty, students, and trainees from vulnerable backgrounds and in particular today to our Black members around the world – we share in your heartbreak, grief, and outrage over these killings. We stand with you in solidarity and we commit as an organization to challenge and confront racism through anti-racist action.

SfRBM will continue to unequivocally denounce and condemn these and other instances of racialized violence and hate. We pledge to continue to advocate on your behalf and support you as we re-commit to address the deep systemic injustice of racism and advancing equity and inclusion for all people.

We do not have all the answers but SfRBM is an organization that values differences, diversity, a shared compassion for humanity and love for science. We call upon our colleagues, members, and the broader scientific community, to commit to anti-racism.

Since everyone’s dreams, aspirations and right to pursue happiness and fulfillment is precious to us, SfRBM’s Diversity, Equity and Inclusion Committee will continue to create opportunities, increase the visibility and promote the achievements of our members from underrepresented minority backgrounds.  


Phyllis A. Dennery, MD
Brown University / Rhode Island Hospital
SfRBM President*
on behalf of the SfRBM Council

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SfRBM Meets with CSR/NIH to Increase Study Section Participation

SfRBM leaders met with key representatives from the NIH Center for Scientific Review in Bethesda, MD on December 9 to discuss how the society can provide a readily accessible pipeline of redox expertise for study sections. SfRBM emphasized the importance of redox biology to a vast array of disease processes as well as an anticipated positive trend of our research in next few years. SfRBM presented data that illustrated the current challenges facing redox-related applications and the lack of qualified study section researchers available to review them.

Of NIH's 180 current standing study sections, over 25% could benefit from redox representation yet either fail to have redox expertise on their roster or redox biology keywords in their listed "Topics" or "Shared Interests and Overlaps". Importantly, approximately 50% of the top 20 study sections receiving redox-related applications neither "advertise" by using redox-related key words nor have redox biologists on their roster. For example, Neural Oxidative Metabolism, Mitochondria and Cell Death Study Section (NOMD), Pathobiology of Kidney Disease Study Section (PBKD) and Tumor Cell Biology Study Section (TCB) all fit this category.

To address the discordance between application focus and representation, CSR indicated that there are opportunities for SfRBM to identify strong reviewers in redox biology to fill some of these gaps. CSR also announced that they are rolling out a new database specifically for societies to make direct reviewer recommendations. SfRBM will be reaching out to members to identify those who would have an interest in serving as a reviewer and would meet CSR prerequisites including a strong publication and research funding track record.

SfRBM also agreed to help CSR diversify the composition of their panels - a topic that was identified as critical to their mission. CSR representatives advised SfRBM how individual redox researchers can improve how they identify their expertise in research grants submitted to NIH. Many investigators may pay little or no attention to this opportunity when submitting a grant application. They pointed out that using "redox biology" alone may not be the best as it is very broad. More specificity in the researcher's profile is crucial in CSR finding reviewers for grant applications. CSR advised paying particular attention to these seemingly trivial details as well as using current terms relative to the field and avoiding terms from 20 years past.

SfRBM's delegation included Phyllis Dennery (President), Holly Van Remmen (President-Elect), Eric Kelley (Advocacy Chair), Chris Kevil (Redox Biology journal co-editor in chief) and Kent Lindeman (Executive Director).

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New Study Finds Antioxidant Therapy is Key to Combating Cell Aging in Mice

WVU’s Eric E. Kelley, Ph.D., and the University of Minnesota’s Laura Niedernhofer, Ph.D., have published a new study in Redox Biology that could change the way we look at aging in humans. Through a new discovery of the main driver of aging in cells, their research shows that it may be possible to slow the aging process. In the 1950’s, Denham Harmon published a groundbreaking theory correlating antioxidants and aging, but since then there have been few findings that validate directly this theory. This new study provides that validation which has been missing.

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