Redox Biology Virtual Seminar Series

SfRBM offers these virtual sessions on a quarterly basis, providing valuable education on a wide range of topics. The sessions are open to SfRBM members only and are offered at no charge.

ROS-signaling Mechanisms and the Roles Peroxiredoxins Play in Them


Date: Thursday, April 25, 2019
Speaker: Elizabeth Veal, Ph.D. - Newcastle University
Length of session: 60 minutes
Time: 12:00 pm Eastern 
(11:00 am Central, 10:00 am Mountain, 9:00 am Pacific; 16:00 UTC;
International attendees should convert the time accordingly.)

Deadline to register was Friday, April 19, 2019.

PROGRAM OVERVIEW
How do cells respond to increases in ROS? What roles do these responses play in aging? What are the roles of peroxiredoxins in these responses? This session will explain how, over the last 15 years, studies exploiting some of the particular advantages of yeast, worms and mathematical models have provided some unexpected answers to these questions. Particular focus will be on the involvement of 2-Cys peroxiredoxins in peroxide-signalling mechanisms and why, in eukaryotes, these thioredoxin peroxidases have evolved to be sensitive to inactivation of their thioredoxin peroxidase activity by hyperoxidation of a catalytic cysteine.

ABOUT THE SPEAKER
Elizabeth Veal is a Reader in Molecular Biology in the Institute for Cell and Molecular Biosciences at Newcastle University. Dr. Veal began her research career with a Wellcome Prize PhD studentship at the University of Liverpool, and following graduation, she accepted a postdoctoral position working on mammalian transcription mechanisms at Harvard Medical School. At Harvard, Dr. Veal worked alongside colleagues making use of the newly discovered RNA interference to disrupt gene function in C. elegans. She later returned to the UK and began a second MRC-funded postdoc at Newcastle University. The success of this postdoc, in identifying new genes required for hydrogen peroxide-signalling mechanisms in yeast, led to an MRC Career Development Award in 2004. Funding from this award allowed Dr. Veal to begin investigating the role of peroxiredoxins in these mechanisms in C. elegans, alongside her studies in the fission yeast Schizosaccharomyces pombe. Accordingly, Dr. Veal spent 3 months training to use C. elegans at the Joslin Diabetes Center and Harvard Medical School. Since her return to the UK, Dr. Veal has established an independent group at Newcastle University, where she continues to use both C. elegans and S. pombe to identify and understand new ROS-signaling mechanisms, and investigate the roles that they play in stress resistance, ageing and innate immunity.

PROGRAM FORMAT
Members can attend an SfRBM Redox Biology Virtual Seminar right from their office or home. All you need to participate is a telephone and a computer with high speed internet connection. The audio is delivered over the telephone (toll-free). Registrants will be provided call in/login information 2-3 days prior to the session and a URL to access the presentation right on the web in real time.

COST
There is no cost for SfRBM members to participate. The webinar is open to SfRBM members only.

Archived Webinars

ROS signaling Mechanisms and the Roles Peroxiredoxins Play in Them

Redox Biology Webinar - April 2019
Speaker: Elizabeth Veal, Ph.D.
Newcastle University
Length of session: 60 minutes


Mechanisms of Mitochondrial Redox Control Over Cellular Function

Redox Biology Webinar - July 2018
Speaker: Edward Chouchani, Ph.D.
Harvard Medical School
Length of session: 60 minutes


Protein Kinase A and G as Redox Targets: Molecular Mechanisms and Physiological Consequences

Virtual Free Radical School Webinar - April 2018
Speaker: Philip Eaton, Ph.D.
King's College - London
Length of session: 60 minutes


The Mitochondria Reticulum of the Muscle Cell

Virtual Free Radical School Webinar - February 2018
Speaker: Robert Balaban, Ph.D.
National Heart, Lung, and Blood Institute
Length of session: 60 minutes


Nitrite: A Physiological Signaling Molecule and Regulator of Mitochondrial Function

Virtual Free Radical School Webinar - November 2017
Speaker: Sruti Shiva, Ph.D.
University of Pittsburgh
Length of session: 60 minutes


The Role of Nrf2 in Cardiovascular Diseases and Cancer

Virtual Free Radical School Webinar - August 2017
Speaker: Anna-Liisa Levonen, Ph.D.
University of Eastern Finland
Length of session: 60 minutes


Lipid Oxidation and Vascular Inflammation

Virtual Free Radical School Webinar - May 2017
Speaker: Valerie O'Donnell, Ph.D.
Cardiff University
Length of session: 60 minutes


Protein Oxidation - By Numbers

Virtual Free Radical School Webinar - February 2017
Speaker: Michael Davies, Ph.D.
University of Copenhagen
Length of session: 60 minutes


Deconvoluting Mixed Redox Messages with Precision Redox Targeting

Virtual Free Radical School Webinar - October 2016
Speaker: Yimon Aye, Ph.D.
Cornell University
Length of session: 65 minutes


Towards Understanding the Role of Copper in SOD and ALS

Virtual Free Radical School Webinar - June 2016
Speaker: Joe Beckman, Ph.D.
Linus Pauling Institute/Oregon State University
Length of session: 60 minutes


Nitrotyrosine: To Die or Not to Die

Trainee Council Webinar
Speaker: Alvaro Estevez, Ph.D.
University of Central Florida
Length of session: 60 minutes


Mitochondrial Superoxide: Whence it Comes, What it Does, and How to Prevent its Production

Virtual Free Radical School Webinar - March 2016
Speaker: Mike Murphy, Ph.D.
Cambridge University, UK
Length of session: 60 minutes


Measuring Redox State When Studying Energy Metabolism

Free Radical School - November 2015
Speaker: Alicia Kowaltowski, Ph.D.
University of Sao Paulo, Brazil
Length of session: 60 minutes


The Wondrous Chemical Biology of "Hydrogen Sulfide" - What You Need to Know, Why You Should Care and Why It Is Connected to Everything Else

Virtual Free Radical School Webinar - Sept 2015
Speaker: Martin Feelisch, Ph.D.
University of Southampton, UK
Length of session: 60 minutes


The Redox Active, Anti-Cancer Agent, (Dp44mT), Overcomes Multidrug-Resistance by Hijacking of P-Glycoprotein

Virtual Free Radical School Webinar - May 2015
Speaker: Des Richardson, Ph.D.
University of Sydney
Length of session: 60 minutes


Oxygen in Human Health: From Life to Death

Virtual Free Radical School Webinar - November 2014
Speaker: Margaret Briehl, Ph.D.
University of Arizona
Length of session: 30 minutes


Pleiotropic Anti-inflammatory Signaling Actions of Redox-derived Fatty Acid Electrophiles

Virtual Free Radical School Webinar - October 2014
Speaker: Bruce Freeman, Ph.D.
University of Pittsburgh
Length of session: 60 minutes


NOS2 and Nitric Oxide as a Driver of Poor Prognosis in Estrogen Receptor Negative Breast Cancer

Virtual Free Radical School Webinar - July 2014
Speaker: David Wink, Ph.D.
NIH/NCI
Length of session: 60 minutes


Roles of Nox Family NADPH Oxidases in Redox-based Innate Immune Responses

Virtual Free Radical School Webinar - February 2014
Speaker: Thomas Leto, Ph.D.
NIH/NAID
Length of session: 60 minutes


NADPH Oxidases in Vascular System: From Health to Disease

Free Radical School - November 2013
Speaker: Ralf Brandes, MD
Goethe-University - Germany
Length of session: 60 minutes


Nitric Oxide and Non-Heme Iron: New Concepts in NO Signaling

Virtual Free Radical School Webinar - October 2013
Speaker: Doug Thomas, Ph.D.
University of Illinois at Chicago
Length of Session: 60 minutes


Translational Redox Biology: New Approaches and Concepts

Virtual Free Radical School Webinar - July 2013
Speaker: Victor Darley-Usmar, Ph.D.
University of Alabama at Birmingham
Length of Session: 60 minutes


Vitamin E Actions and Regulations

Virtual Free Radical School Webinar - May 2013
Speaker: Maret Traber, Ph.D.
Linus Pauling Institute
Length of Session: 60 minutes


NO Regulation of Pulmonary Inflammation

Virtual Free Radical School Webinar - March 2013
Speaker: Andrew Gow, Ph.D.
Rutgers University 
Length of Session: 60 minutes


NADPH Oxidases: Structure and Function

Virtual Free Radical School Webinar - October 2012
Speaker: Kathy Griendling, Ph.D.
Emory University 
Length of Session: 60 minutes


Mitochondrial Redox Processes

Virtual Free Radical School Webinar - May 2012
Speaker: Alicia Kowaltowski, Ph.D.
University of São Paulo
Length of Session: 60 minutes


Hemoglobin Mediated NO Signaling

Virtual Free Radical School Webinar - February 2012
Speaker: Daniel Kim-Shapiro, Ph.D.
Wake Forest University
Length of Session: 60 minutes


Metabolic Oxidative Stress and Cancer

Free Radical School - 2011 Annual Meeting
Speaker: Douglas Spitz, Ph.D.
The University of Iowa 
Length of session: 30 minutes


Sirtuin 3: A Mitochondrial Watchdog Protein

Free Radical School - 2011 Annual Meeting
Speaker: David Gius, MD, Ph.D.
Vanderbilt-Ingram Cancer Center
Length of session: 30 minutes


Targeting Oxidative Stress in Neurodegenerative Diseases

Free Radical School - 2011 Annual Meeting
Speaker: Manisha Patel, Ph.D.
University of Colorado
Length of Session: 40 minutes


Oxygen and Gene Expression

Virtual Free Radical School Webinar - November 2011
Speaker: Phyllis Dennery, MD
Children's Hospital of Philadelphia
Length of session: 60 minutes


Glutathione: Protective Roles and Regulation of its Synthesis

Virtual Free Radical School Webinar - July 2011
Speaker: Henry Forman, Ph.D.
University of California - Merced
Length of session: 60 minutes


Chemical Biology of Peroxynitrite

Virtual Free Radical School Webinar - April 2011
Speaker: Gerardo Ferrer-Sueta, Ph.D.
Universidad de la República – Uruguay
Length of session: 60 minutes 


ROS/RNS in Ischemia Reperfusion

Virtual Free Radical School Webinar - January 2011
Speaker: Chris Kevil, Ph.D.
LSU Health Sciences Center
Length of session: 60 minutes


From NO to Nitrite and Nitrate...and Back Again: Roles in Mammalian Biology

Free Radical School - 2010 Annual Meeting
Speaker: Rakesh Patel, Ph.D.
University of Alabama at Birmingham
Length of session: 35 minutes


The Endoplasmic Reticulum: An Emerging Player in Redox Pathophysiology

Free Radical School - 2010 Annual Meeting
Speaker: Francisco Laurindo, MD
University of São Paulo
Length of session: 40 minutes


The Biological Chemistry of Hydrogen Peroxide

Virtual Free Radical School Webinar - October 2010
Speaker: Christine Winterbourn, Ph.D.,
University of Otago
Length of session: 60 minutes


Chemical Foundations of 'Reactive Species' and Predictions of the Mechanisms of Specificity

Virtual Free Radical School Webinar - July 2010
Speaker: Jack R. Lancaster, Ph.D., The University of
Alabama - Birmingham
Length of session: 60 minutes


Redox Signaling Through Protein Cysteine Residues

Virtual Free Radical School Webinar - February 2010
Speaker: Neil Hogg, Ph.D., Medical College of Wisconsin
Length of session: 60 minutes


The Many Faces of Oxygen, Sulfur, & Selenium in Redox Biology

Virtual Free Radical School Webinar - October 2009
Speaker: Garry Buettner, Ph.D., The University of Iowa
Length: 50 minutes*