Conference Program

Daily Schedules

Wednesday, November 17
  Pre-Conference Workshop
Thursday, November 18
Friday, November 19
Saturday, November 20

WEDNESDAY, NOVEMBER 17, 2021

7:00 am - 6:30 pm
Registration/Information Desk

PRE-CONFERENCE WORKSHOP*
Critical Advances in Electrophilic Drug Development
Chairs: Carola Neumann, MD, University of Pittsburgh, USA, Francisco Schopfer, PhD, MBA, University of Pittsburgh, USA and Bruce Freeman, PhD, University of Pittsburgh, USA
*Additional cost - requires registration

*Included with virtual registration

Redox signaling affects the activity of specific enzyme isoforms. This property can be harnessed for rational drug design. Covalent drugs have resurged in recent years and several reports have demonstrated the general virtue of developing irreversible or reversible inhibitors. In fact, many modern pharmaceuticals contain electrophilic appendages with several employing a warhead that hijacks active side nucleophiles while others take advantage of nucleophilic sidechains that do not participate in enzymatic chemistry, but readily react with electrophiles. Thus, targeted covalent inhibitors and chemical probes have successfully become integral parts of drug discovery approaches for several diseases such as cancer and neurodegenerative diseases. However, some critical challenges and questions remain regarding translational aspects. Those include target specificity and the advantages of reversible vs irreversible nature of the covalent interaction. This session will inform the audience about the latest developments in electrophilic drug development, emphasize possible ways to address these challenges and an update of covalent inhibitors in the clinic.

PART I: EMERGING TECHNIQUES IN DEVELOPING CYSTEINE TARGETING DRUGS

9:00 am - 9:05 am
Welcome / Part I Overview
Francisco Schopfer, PhD, University of Pittsburgh, USA

9:05 am - 9:35 am
Challenges in Covalent Drug Design
Yimon Aye, PhD, École Polytechnique Fédérale de Lausanne, Switzerland

9:35 am - 10:05 am 
DocKovalent: Functionalizing Targeted Covalent Inhibitors
Nir London, PhD, Weizmann Institute of Science, Israel

10:05 am - 10:35 am
Tethering and Targeting Cysteine Reactivity
Michelle Arkin, PhD, University of California San Francisco, USA

10:35 am - 10:55 am
BREAK

10:55 am - 11:20 am
Targeting Proteins with Photoswitchable Affinity Labels (PALs)
Dirk Trauner, PhD, New York University, USA

11:20 am - 11:50 am
Nitroalkenes: A Promising New Drug Class
Francisco Schopfer, PhD, University of Pittsburgh, USA

12:00 am - 1:00 pm
Lunch

PART II: EXAMPLES OF CYSTEINE TARGETING DRUGS

1:00 pm - 1:05 pm
Welcome / Part II Overview
Carola Neumann, MD, University of Pittsburgh, USA

1:05 pm - 1:35 pm
Electrophilic Inhibitors in Neurodegenerative Diseases
Stuart A. Lipton, MD, PhD, Scripps Florida, USA

1:35 pm - 2:05 pm    
The Discovery of Sotorasib (AMG 510): First-in-Class Investigational Covalent Inhibitor of KRAS G12C
Ryan Wurz, PhD, Amgen, USA

2:05 pm - 2:35 pm
Development of a Novel Cysteine Targeting RAD51 Inhibitor
Carola Neumann, MD, University of Pittsburgh, USA

2:35 pm - 2:50 pm
BREAK

2:50 pm - 3:20 pm
Targeting Cysteine of Superoxide Dismutase and the Main Protease of SARS-CoV-2 for Potential Therapeutic Solution
Samar Hasnain, PhD, University of Liverpool, UK

3:20 pm - 4:00 pm
Closing Remarks and Roundtable Discussion with the Experts
Bruce Freeman, PhD, University of Pittsburgh, USA

5:30 pm - 7:00 pm
Welcome Reception


THURSDAY, NOVEMBER 18, 2021

ANNUAL CONFERENCE BEGINS

7:50 am - 8:00 am
SfRBM President's Welcome
Holly Van Remmen, PhD, Oklahoma Medical Research Foundation, USA - SfRBM President 

SUNRISE FREE RADICAL SCHOOL
8:00 am - 9:00 am
Back to the Basics
Chairs: Kimberly Dunham-Snary, Ph.D., Queen's University, Canada and Adam Case, PhD, Texas A&M University, USA
*Included with virtual registration

8:00 am - 8:30 am
What are Free Radicals and Reactive Oxygen Species
Maria Clara Franco, PhD, Oregon State University, USA

8:30 am - 9:00 am
Redox Signaling 101
Aimee L. Eggler, PhD, Villanova University, USA

PLENARY SESSION 1

9:30 am - 12:00 pm
Reactive Oxygen Species as mediators of Neuromuscular Interactions Underlying Age-Related Atrophy
Chairs: Malcolm J Jackson PhD DSc FRCPath FTPS, University of Liverpool, UK and Holly Van Remmen PhD, Oklahoma Medical Research Foundation, USA
*Included with virtual registration

This proposed session encompasses the conceptually novel “two-hit” hypothesis for sarcopenia wherein defects in neuronal function arising from altered redox homeostasis initiate disruption of neuromuscular Junctions (NMJs), but a second failure in ROS-mediated post-synaptic muscle processes is required to generate the full phenotype. The session leads through the basic mechanisms involved through to the proposals of novel ROS-targeted interventions aimed at restoring neuromuscular function in old age.

This session brings together experts in the fields of redox biochemistry, muscle physiology, mitochondrial function, neuromuscular synapse function and neurobiology using technical innovations including neuromuscular tissue engineering, redox proteomics, single cell transcriptomics and mass spectrometry to address the hypothesis of the potential for a major role of Reactive Oxygen Species (ROS) in mediating both pre- and post-synaptic disruption in old age.

9:30 am - 10:00 am
Contribution of Both Pre- and Post-Synaptic Changes in the Initiation and Progression of Sarcopenia: Role of Altered ROS
Susan V Brooks, PhD, University of Michigan, USA

10:00 am - 10:30 am
Targeting Mitochondrial Hydrogen Peroxide to Mitigate Sarcopenia
Bumsoo Ahn, PhD, Oklahoma Medical Research Foundation, USA

10:30 am - 11:00 am
BREAK

11:00 am - 11:30 am
The Role of Altered Skeletal Muscle – Neuronal Cross-Talk in Sarcopenia
Anne McArdle PhD, University of Liverpool, UK

11:30 am - 12:00 pm
Oxidation of Cysteine Thiols As Mediators of Skeletal Muscle Responses to Exercise
Malcolm J Jackson PhD DSc FRCPath FTPS, University of Liverpool, UK

PLENARY SESSION 2
9:30 am - 12:00 pm
Redox Signaling in the Nervous System
Chairs: Andrés Trostchansky, PhD, Universidad de la República, Uruguay and Eugenio Barone, PhD, Sapienza University of Rome, Italy
*Included with virtual registration

Oxidative stress and inflammatory processes greatly contribute to the onset and progression of neurodegenerative disorders. Cellular redox signaling and energy metabolism are impaired in neurons, astrocytes, or glial cells prompting a rise in free radical species and oxidatively damaged molecules, which accumulate and lead to cell dysfunction and death. The symposium will cover emerging evidence highlighting the impact of metabolism and redox signaling on genetic and epigenetic regulation of gene transcription as well as protein expression and activity, indicating the complexity of the molecular mechanisms deployed by brain cells to cope with oxidative stress and inflammatory processes.

9:30 am - 10:00 am
Can Oxylipins and SPM be Markers of ALS? Lipidomic Analysis in Human Patients
Andrés Trostchansky, PhD, Universidad de la República, Uruguay

10:00 am - 10:30 am
Role of Sulfhydration in Age-related Neurodegenerative Diseases
Bindu D. Paul, MSc, PhD, Johns Hopkins University School of Medicine, USA

10:30 am - 11:00 am
BREAK

11:00 am - 11:30 am 
Inhibition of Tetrahydrobiopterin Production Induces Analgesia by Compromising T Cell Mitochondrial Bioenergetics
Alexandra Latini, PhD, Universidade Federal de Santa Catarina, Brazil

11:30 am - 12:00 pm             
Insulin Signaling Regulates Mitochondrial Bioenergetics in the Brain: Insight for the Development of Neurodegenerative Diseases
Eugenio Barone, PhD, Sapienza University of Rome, Italy

12:00 pm - 12:30 pm
SfRBM Year in Review: Annual Member Meeting

12:30 pm - 2:30 pm
Lunch
Attendees on own

1:00 pm - 2:15 pm
Professional Development Session 1: Managing your Research Enterprise: From starting up to maintaining a post-tenure research program

1:00 pm - 2:15 pm
Professional Development Session 2Job Hunting as a Scientist: From preparing an application package to interviewing

2:30 pm - 4:15 pm
Oral Presentations from Submitted Abstracts
3 concurrent sessions

4:15 pm - 6:45 pm
Formal Poster Presentations

9:00 pm - 11:00 pm
Hospitality

FRIDAY, NOVEMBER 19, 2021

7:00 am - 6:30 pm
Registration/Information Desk

SUNRISE FREE RADICAL SCHOOL
8:00 am - 9:00 am
Back to the Basics
Chairs: Kimberly Dunham-Snary, Ph.D., Queen's University, Canada and Adam Case, PhD, Texas A&M University, USA
*Included with virtual registration

8:00 am - 8:30 am
Mitochondrial ROS Generation - a Complex Matter
Paul S. Brookes, PhD, University of Rochester, USA

8:30 am - 9:00 am
Chemical and Cellular Aspects of Disulfide Redox Signaling
Edward Moreira Bahnson, PhD, University of North Carolina at Chapel Hill, USA

PLENARY SESSION 3
9:30 am - 12:00 pm
Building, Upkeeping and Recycling Mitochondria
Chairs: Alicia Kowaltowski, MD, PhD, Universidade de São Paulo, Brazil and Andrew Wojtovich, PhD, University of Rochester Medical Center, USA
*Included with virtual registration

Mitochondria are metabolic hubs that control redox signaling events. Mitochondrial redox changes can lead to diverse physiologic outputs depending on context, despite originating from the same organelle. This session will focus on how different mitochondrial redox signals lead to distinct changes in mitochondrial oxidant production, the regulation of their release from mitochondria, and the turnover and maintenance of mitochondrial membranes and DNA.

9:30 am - 10:00 am
Mitochondrial Biogenesis and Protein Translocation into Mitochondria
Carla Koehler, M.S.,PhD, University of California, Los Angeles, USA

10:00 am - 10:30 am 
Mitochondrial Redox Signaling in Acute Hypoxia
Antonio Martínez-Ruiz, PhD, Hospital Universitario de La Princesa, Spain

10:30 am - 11:00 am
BREAK

11:00 am - 11:30 am
Rescuing Mitochondrial Intermembrane Space Protein Biogenesis Under Oxidative Stress
Kostas Tokatlidis, PhD, University of Glasgow, Scotland

11:30 am - 12:00 pm 
Using Chemoptogenetic Approaches to Interrogate Mitochondrial Function
Ben Van Houten, PhD, University of Pittsburgh, USA

PLENARY SESSION 4 
9:30 am - 12:00 pm
Disulfide Chemistry and Function in Cardiovascular Disease
Chairs: Philip Hogg, University of Sydney, Australia and Francisco Laurindo, MD, University of São Paulo School of Medicine, Brazil
*Included with virtual registration

Since the discovery of protein disulfide bonds more than 50 years ago they have been assumed to be fully formed and inert in the mature protein. Recent findings have upended these fundamental assumptions about protein structure and function. Numerous disulfides exist in unbound form in mature proteins and a subset of the bonds, the allosteric disulfides, control the function of the protein when reduced or oxidised by vascular thiol isomerases.

9:30 am - 10:00 am
PDI as a Biomarker And Therapeutic Target In Thrombosis
Robert Flaumenhaft, MD, PhD, BIDMC/Harvard Medical School, USA

10:00 am - 10:30 am
How Functional Disulfides Regulate Proteins In Blood Flow
Frauke Graeter, PhD, Heidelberg Institute for Theoretical Studies, Germany

10:30 am - 11:00 am
BREAK

11:00 am - 11:30 am
Blood And Guts: Intestinal Mucins Shed Light On The Disulfide-Mediated Assembly Of Von Willebrand Factor
Deborah Fass, PhD, Weizmann Institute of Science, Israel

11:30 am - 12:00 pm 
Multiple Disulfide‐Bonded forms of Blood Proteins
Philip Hogg, PhD, University of Sydney, Australia

12:00 pm - 12:30 pm
SfRBM Discovery Award Lecture
Title: TBD

Ines Batinic-Haberle, Duke University, USA

12:30 pm - 2:30 pm
Lunch 
Attendees on own

1:00 pm - 2:15 pm
Professional Development Session 3: Clear, Consise and Cool - Tips for Effectively Communicating Science

1:00 pm - 2:15 pm
Professional Development Session 4: Trainee Council Session

2:30 pm - 4:15 pm
Oral Presentations from Submitted Abstracts
3 concurrent sessions

4:15 pm - 6:45 pm
Formal Poster Presentations

6:45 pm - 9:00 pm
Opening Doors Event: Mentoring Matters: Building Mentoring Relationships with a Focus on Inclusion and Diversity

9:00 pm - 11:00 pm
Hospitality

SATURDAY, NOVEMBER 20, 2020

7:00 am - 6:30 pm
Registration/Information Desk

SUNRISE FREE RADICAL SCHOOL 
8:00 am - 9:00 am
Back to the Basics
Chairs: Kimberly Dunham-Snary, Ph.D., Queen's University, Canada and Adam Case, PhD, Texas A&M University, USA
*Included with virtual registration

8:00 am - 8:30 am
A Historical Overview of the Successes and Failures of Antioxidant Therapies
Chris Kevil, PhD, LSU Health Shreveport, USA

8:30 am - 9:00 am
Translating Your Science to a Clinical Trial
Rebecca Oberley-Deegan, PhD, University of Nebraska Medical Center, USA

PLENARY SESSION 5
9:30 am - 12:00 pm
New Advances in Targeting the Cellular Redox Environment as a Therapeutic Strategy
Chairs: Ines Batinic-Haberle, PhD, Duke University Medical Center, USA and Rebecca Oberley-Deegan, PhD, University of Nebraska Medical Center, USA
*Included with virtual registration

Over the last decade the clinical development of drugs that target cellular redox environment has intensified. Two members of different classes of such compounds, a Mn porphyrin, BMX-001, and a Mn cyclic polyamine, GC4419, have progressed into Phase II/III clinical trials on cancer patients as protectors of normal tissues and anticancer agents.

9:30 am - 10:00 am   
Metalloporphyrins: An Opportunity to Transform Radiation Therapy for High Grade Glioma Patients
Katherine B. Peters, PhD, MD, Duke University Cancer, USA

10:00 am - 10:30 am
Utilizing SOD Mimics to Protect Normal Tissues While Enhancing Tumor Responses to Cancer Therapy
Douglas R. Spitz, PhD, University of Iowa, USA

10:30 am - 11:00 am
BREAK

11:00 am - 11:30 am 
Antioxidant and Pro-Oxidant Actions of Mn Porphyrin-Based Therapeutics
Ines Batinic-Haberle, PhD, University Medical Center Durham, USA

11:30 am - 12:00 pm     
Understanding the Mechanisms by Which Manganese Porphyrins Protect from Radiation-Induced Toxicities
Rebecca Oberley-Deegan, PhD, University of Nebraska Medical Center, USA

12:00 pm - 12:30 pm
New Member Welcome Meeting

12:30 pm - 2:30 pm
Lunch
Attendees on own

2:30 pm - 4:15 pm
Oral Presentations from Submitted Abstracts
3 concurrent sessions

4:15 pm - 6:45 pm
Formal Poster Presentations

7:30 pm - 9:30 pm
Closing Awards Banquet

9:30 pm - 11:00 pm
Hospitality

SfRBM 2021 officially adjourns after the Closing Awards Banquet on Saturday, November 20.