Home Wednesday
Pre-Conference Workshop
Opening Session
Thursday
Friday
Saturday
5:00 pm - 8:00 pm
Registration/Information Desk
7:00 am - 6:30 pm
Registration/Information Desk
PRE-CONFERENCE WORKSHOP*
9:00 am - 4:00 pm
New Technologies and Informatics Strategies for Revealing the Interface Between Metabolism and Redox Biology
Chairs: Melissa Kemp, Ph.D., Georgia Institute of Technology, USA and Edward Chouchani, Ph.D. Harvard Medical School & Dana-Farber Cancer Institute, USA
*Additional cost - requires registration
Reactive oxygen species (ROS) are often described and studied as a monolithic entity, they are in fact a diverse class of redox-active molecules each of which exhibit distinct dynamics, reactivity, and metabolic consequences. To move on from the inexact concept of “oxidative stress,” precise examination of ROS signaling in physiology requires assessment of several variables. Important questions include the following: What reactive species are involved in driving a physiological process? Where are they being produced? What are their molecular targets? What are the consequences of ROS modification of these targets? The extent to which these questions can be answered relies on tools that allow us to examine redox processes in intact organisms with precision and accuracy and integrating these with systems biology analysis. Since physiological ROS production exhibits extraordinary spatiotemporal regulation and is highly integrated, metabolic inputs and regulator factors that both initiate and respond to redox signals must examined in their native environment, which is technically challenging. The new analytical technologies related to the big data sets associated with redox biology are having a major impact on both basic and translational research. The integration of redox biology into these rapidly advancing fields will likely change our perspective on both fundamental biological mechanisms the development of novel therapeutics. This workshop will focus on how these tools can be applied to yield mechanistic insights into the role ROS and metabolism play as regulatory molecules in physiology and pathophysiology with a focus on bioenergetic function, metabolism and thiol networks encompassing advanced analytical methods and bioinformatics.
9:00 am - 9:05 am
Welcome / Part I Overview
9:05 am - 9:35 am
Identification and Manipulation of Metabolic Pethways that Control ROS Signaling in Phsyiology and Pathophysiology
Edward Chouchani, Ph.D., Harvard Medical School & Dana-Farber Cancer Institute, USA
9:35 am - 10:05 am
Respirometry Analysis of Frozen Tissue Bank: Novel Approach to Respirometry in Previously Frozen Samples, in Homogenates and Buccal Swabs
Orian Shirihai, MD, Ph.D., University of California, Los Angeles, USA
10:05 am - 10:35 am
Informatics Methods for Integrating Complex Metabolic and Redox Data Sets
Karan Uppal, Ph.D., Emory University, USA
10:35 am - 10:55 am
Break
10:55 am - 11:20 am
The Integration of Metabolomics and Bioenergetics in Human Platelets and the Potential in Translational Research
Victor Darley-Usmar, Ph.D., University of Alabama at Birmingham, USA
11:20 am - 11:50 am
LC-MS and Bioinformatixs Solutions to Study Redox Biology Regualtion of Epilipidome
Maria Fedorova, Ph.D., Leipzig University, Germany
11:50 am - 1:00 pm
Lunch
1:00 pm - 1:05 pm
Part II Overview
1:05 pm - 1:35 pm
Cysteine-Mediated Redox Signaling: Chemical Tools for Biological Discovery
Kate Carroll, Ph.D., Scripps Research, Florida Campus, USA
1:35 pm - 2:05 pm
Personalized Models of Redox Metabolism from Transcriptomic Datasets
Melissa Kemp, Ph.D., Georgia Institute of Technology, USA
2:05 pm - 2:35 pm
Harnessing the Sentinels of the Cysteine Redoxome with Proteomics and Bioinformatics
Jason Held, Ph.D., Washington University in St. Louis School of Medicine, USA
2:35 pm - 2:50 pm
Break
2:50 pm - 3:20 pm
Systemic Approaches to Identify Endogenous Antioxidants of Cancer Cells
Kivanc Birsoy, Ph.D., The Rockefeller University, USA
3:20 pm - 3:50 pm
Genetics to Uncover Redox Biology and Metabolic Pathways
Navdeep Chandel, Ph.D., Northwestern University, USA
3:50 pm - 4:00 pm
Summary
5:00 pm - 5:10 pm
SfRBM President's Welcome
Phyllis Dennery, MD, Brown University / Rhode Island Hospital, USA - SfRBM President
PRESIDENTIAL PLENARY SESSION
5:10 pm - 7:10 pm
From Bench to Bedside and Back: Redox in Medicine
5:10 pm - 5:40 pm
Glutaredoxin 1 and the Sexual Dimorphic Reprogramming of Blood Monocytes by Nutrient Stress
Reto Asmis, Ph.D., Wake Forest University, USA
5:40 pm - 6:10 pm
Mitochondria-Coupled Glucose Phosphorylation in Brain: Redox Role During Neurodevelopment in Health and Disease
Antonio Galina, Ph.D., Federal University of Rio de Janeiro, Brazil
6:10 pm - 6:40 pm
Visualizing Glutathione Utilization in the Zebrafish Embryo: When and Where
Alicia Timme-Laragy, Ph.D., University of Massachusetts Amherst, USA
6:40 pm - 7:10 pm
Vitamin C and the Cancer Epigenome: Translating to Treatment of Leukemia
Kirsten Groenbaek, MD, DMSc, University of Copenhagen, Denmark
7:15 pm - 9:00 pm
Welcome Reception
7:15 pm - 8:30 pm
Trainee Welcome Event
9:00 pm - 11:00 pm
Hospitality
7:00 am - 6:30 pm
Registration/Information Desk
SUNRISE FREE RADICAL SCHOOL
8:00 am - 9:00 am
Back to the Basics
Chairs: Kimberly Dunham-Snary, Ph.D., Queen's University, Canada and Carola Neumann, MD, University of Pittsburgh, USA
8:00 am - 8:30 am
Oxidative Stress, Redox Signaling, and Autophagy: Cell Death Versus Survival
Rodrigo Franco, Ph.D., University of Nebraska-Lincoln, USA
8:30 am - 9:00 am
Intracellular Iron Transport and the Discovery of Chaperones of the PCBP Class: The Formation of Metabolons
Des Richardson, Ph.D., University of Sydney, Australia
PLENARY SESSION 1
9:30 am - 12:00 pm
Intracellular Metal Trafficking: Consequences for Redox Enzyme (alternative) Activities
Chairs: Marcelo Bonini, Ph.D, Medical College of Wisconsin, USA and Michael Graham Espey, Ph.D., National Cancer Institute, USA
Metals are central cofactors enabling redox reactions critical for the metabolism, DNA synthesis and repair, cellular and organ function. Their mishandling, release or misincorporation into proteins have significant consequences from loss of enzyme activity and destructive redox chemistry. More recently, the misincorporation of alternative ligand metals to enzyme active sites has been shown to lead to alternative activities vastly different from physiology. This session proposes to review and update the audience about the latest research in intracellular metal trafficking, incorporation to redox enzymes and the consequences of errors in metal handling for redox physiology and pathology.
9:30 am - 10:00 am
Accounting for Essential Transition Metals in Cancer and Development
Thomas O'Halloran, Ph.D., Northwestern University, USA
10:00 am - 10:30 am
Metals and SOD Enzymes: Tales from a Successful Fungal Pathogen
Valeria Culotta, Ph.D., Johns Hopkins University, USA
10:30 am - 11:00 am
Break
11:00 am - 11:30 am
The Many Faces of Superoxide Dismutase 2: A Metal issue?
Marcelo Bonini, Ph.D., Medical College of Wisconsin, USA
11:30 am - 12:00 pm
Iron Takes Center Stage in Cancer Therapeutics: Ferroptosis and Ovarian Cancer
Suzy Torti, Ph.D., University of Connecticut Health Center, USA
PLENARY SESSION 2
9:30 am - 12:00 pm
Oxy-Inflammation, Redox Signaling and Autophagy: Crosstalk in Health and Disease
Chairs: Saverio Francesco Retta, Ph.D., University of Turin, Italy and Jianhua Zhang, Ph.D., University of Alabama at Birmingham, USA
This session aims at highlighting current knowledge of the crosstalk between redox signaling and autophagy, including mitophagy, in homeostasis and diseases. Indeed, a growing body of evidence suggests that a tight interconnection between altered autophagy and abnormal redox signaling is integral to the development of major human diseases associated with oxidative stress and inflammation, including neurodegenerative and cardiovascular diseases and cancer. A comprehensive understanding of the complex molecular crosstalk between redox signaling and autophagy should therefore enable the development of innovative combination therapies for the prevention and treatment of complex human diseases. In particular, this session will focus on the molecular mechanisms underlying the interplay between mitochondria, redox signaling and autophagy in cellular responses to oxidative stress and inflammation and the emerging potential and persisting obstacles for therapeutic interventions.
9:30 am - 10:00 am
Autophagy, Mitochondria and Oxidative Stress: Crosstalk and Redox Signaling
Jianhua Zhang, Ph.D., University of Alabama at Birmingham, USA
10:00 am - 10:30 am
Crosstalk Between Redox Signaling and Autophagy in Cerebral Cavernous Malformation Disease: From Basic Mechanisms to Therapeutic Strategies
Saverio Francesco Retta, Ph.D., University of Turin, Italy
10:30 am - 11:00 am
Break
11:00 am - 11:30 am
The Pharmacology of Mitochondrial Cholesterol in Redox Signalling, Quality Control and Retrograde Response
Michelangelo Campanella, PharmD, Ph.D., University of London, UK
11:30 am - 12:00 pm
Autophagy Modulation for Precision Cancer (immuno)Therapy
Lorenzo Galluzzi, Ph.D., Weill Cornell Medical College, USA
12:00 pm - 12:30 pm
SfRBM Year in Review: Annual Member Meeting
12:30 pm - 2:30 pm
Lunch
Attendees on own
1:00 pm - 2:15 pm
Professional Development Session 1: How to Publish a Strong Paper in Redox Biology and Avoid Fatal Errors/Rigor in Redox Methods
Trent Tipple, MD, University of Oklahoma College of Medicine, USA and Samantha Giordano-Mooga, Ph.D., University of Alabama at Birmingham, USA
1:00 pm - 2:15 pm
Professional Development Session 2: Grant Review Section
Damian Guerra, Ph.D., University of Colorado, USA and Rajasekaran Namakkal, Ph.D., University of Alabama at Birmingham, USA
2:30 pm - 4:15 pm
Oral Presentations from Submitted Abstracts
3 concurrent sessions
4:15 pm - 6:45 pm
Formal Poster Presentations
6:45 pm - 9:00 pm
Opening Doors Event: Professionalism - Building Success in Science
Dr. Sonia Flores is a long standing member of the redox community and a national leader on diversity, inclusion, and equity. She is a member of the NIH working group that develops recommendations on how to address issues regarding unprofessional behavior in science and medicine. This interactive Opening Doors session will address harassment and bias in the field of redox biology and medicine and approaches to minimize such problems in the community. WIS invites all SfRBM 2019 attendees to join us at this event.
7:00 pm - 7:30 pm
FRBM Editorial Board Meeting
7:30 pm - 8:00 pm
Redox Biology Editorial Board Meeting
8:00 pm - 9:00 pm
FRBM and Redox Biology Editors & Editorial Board Members Joint Reception
9:00 pm - 11:00 pm
Hospitality
7:00 am - 6:30 pm
Registration/Information Desk
SUNRISE FREE RADICAL SCHOOL
8:00 am - 9:00 am
Back to the Basics
Chairs: Kimberly Dunham-Snary, Ph.D., Queen's University, Canada and Carola Neumann, MD, University of Pittsburgh, USA
8:00 am - 8:30 am
Effects of Reactive Oxygen Species on the Cell Nucleus
Sophie Lelievre, DVM, Ph.D., Purdue University, USA
8:30 am - 9:00 am
The Role of Nrf2 in Cancer
Anna-Liisa Levonen, MD, Ph.D., University of Eastern Finland, Finland
PLENARY SESSION 3
9:30 am - 12:00 pm
Beyond the Cell: Oxidation of the Extracellular Matrix in Development, Disease and Treatment
Chairs: Michael Davies, D.Phil., University of Copenhagen, Denmark and Yvonne Janssen-Heininger, Ph.D., The University of Vermont, USA
The redox environment inside cells is very different to that outside the cell, and it is clear that many extracellular environments are both more oxidizing and also subject to extensive oxidation. This difference in redox environments results in significant changes in oxidation chemistry and biology, altered redox equilibria, and antioxidant defense mechanisms. Oxidation events outside cells also play a critical role in driving many diseases, particularly in fibrotic pathologies. Many extracellular proteins are highly abundant, long-lived and relatively poorly protected against damage. They can therefore accumulate high levels of modification during ageing and disease, resulting in their increasing use as biomarkers of long-term oxidative stress. However, these extracellular modifications are not always innocent bystanders as oxidized extracellular matrix materials are increasingly recognized to play a key role in determining cell function and fate. Extracellular oxidation is critical for tissue assembly and development, and specific and localized oxidation is essential to life, particularly with regard to tissue architecture and function. Deliberate exogenous oxidant formation also appears to be a promising method of repairing tissue damage, with animal and human trials indicating that controlled oxidation can be of major therapeutic use in tissue repair after injury. This session will examine extracellular oxidation from chemistry through to the bedside, and encompass studies on the role of oxidants in tissue development, the chemistry and biology of disease, and the use of oxidants to effect tissue repair.
9:30 am - 10:00 am
Redox Perturbations, Extracellular Matrix and Lung Fibrosis
Victor Thannickal, MD, University of Alabama at Birmingham, USA
10:00 am - 10:30 am
Modifications to the Disease Structure of Arterial Wall as a Driver of Cardiovascular Disease
Michael Davies, D.Phil., University of Copenhagen, Denmark
10:30 am - 11:00 am
Break
11:00 am - 11:30 am
Peroxidase-Mediated Assembly and Repair of Tissues in Development and Disease
Gautam (Jay) Bhave, MD, Ph.D., Vanderbilt University Medical Center, USA
11:30 am - 12:00 pm
Light-Activated Tissue Repair and Regeneration
Robert Redmond, Ph.D., Harvard Medical School, USA
PLENARY SESSION 4
9:30 am - 12:00 pm
Nrf n' Turf: Nrf2 Redox Signaling and Strategies to Drug Cancer Cell Metabolism
Chairs: Michael Graham Espey, Ph.D., National Cancer Institute, USA and Nadine Hempel, Ph.D., Pennsylvania State University, USA
The NRF2-KEAP1-ARE pathway is a key regulator of the cellular redox state, and pivotal in defense against xenobiotic and oxidative stresses. Cancer cells exploit NRF2-KEAP1 to alter redox states leading to metabolic reprogramming and resistance. Speakers in this session will discuss emergent findings that reveal the mechanistic underpinnings of oncogenic corruption in Nrf2-mediated signaling, with attendees gaining an integrative understanding of redox, metabolism and cancer phenotypes. Our session will challenge the dogma that cancer metabolism is not druggable. Each speaker will explore how Nrf2-oncogene addiction in cancer cells potentially creates vulnerabilities that may be targeted using novel translational strategies.
9:30 am - 10:00 am
Investigation of Selective NRF2-Dependent Metabolic Liabilities
Gina DeNicola, Ph.D., Moffitt Cancer Center, USA
10:00 am - 10:30 am
Redox Sensors to Map Druggable Co-dependencies in NRF2 Cancers
Liron Bar-Peled, Ph.D., Harvard Medical School, USA
10:30 am - 11:00 am
Break
11:00 am - 11:30 am
Translating Nrf2-regulated Translation
Iok In Christine Chio, Ph.D., Columbia University, USA
11:30 am - 12:00 pm
Mutual Exclusivity of Nrf2 and Engineering Cancer Metabolism
Thales Papagiannakopoulos, Ph.D., NYU Langone Medical Center, USA
12:00 pm - 12:30 pm
SfRBM Discovery Award Lecture: Chemogenetic Approaches to Redox Biology
Vsevolod Belousov, Ph.D. Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russia & Thomas Michel, MD, Ph.D., Harvard Medical School, Brigham & Women's Hospital, USA
12:30 pm - 2:30 pm
Lunch
Attendees on own
12:45 pm - 2:00 pm
Special Luncheon Session - Sponsored by Baker Ruskinn
Understanding the Dynamics of Cellular Activity and the Culture Oxygen Environment
Kara Held, Ph.D., Science Director, Baker Ruskinn and Walker Inman, Founder, Lucid Scientific
The Baker Ruskinn and Lucid Scientific lunch and learn is an opportunity to understand the benefits of “Physoxic” Cell Culture and the importance of regulating and monitoring oxygen in cell culture environments. During the lunch, we will present our companies’ visions for mimicked in vivo cell culture solutions, the advantages of cell culture using Continuous Physiological Oxygen, and how to measure oxygen consumption in real-time. We will discuss recent project results reflecting true physiological conditions while using the Baker Ruskinn solutions and oxygen conditions using Lucid Scientific’s Resipher. Please join us for a bite to eat and an engaging overview of the dynamics of the cell culture oxygen environment.
Click here to register for this session.
Lunch will be provided to all session attendees.
1:00 pm - 2:15 pm
Professional Development Session 3: Transitioning from Non-Tenure Research to Academic Tenure Track Positions & Alternative Careers
Benoit Boivin, Ph.D., SUNY Polytechnic Institute, USA, Jack Lancaster, Ph.D., University of Pittsburgh and Karina Ckless, SUNY Plattsburgh, USA
Transitioning from a post-doctoral position, or non-tenure equivalent, to an academic tenure-track position in the competitive STEM field is not an easy task. It requires planning to acquire the proper skill set and experience tailored to the type of institution you are applying for. In this session the panelists, senior faculty and recent hires from research or teaching-oriented institutions, will discuss the requirements necessary to be a competitive applicant to a tenure-track position.
Panelists to include: Andres Melendez, Ph.D., SUNY Polytechnic Institute, Edward Moreira Bahnson, Ph.D., University of North Carolna at Chapel Hill, Albert van der Vliet, Ph.D., University of Vermont, and Michael Espey, Ph.D, National Cancer Institute.
1:00 pm - 2:15 pm
Professional Development Session 4: Navigating Power Dynamics in Science
Archit Rastogi, University of Massachusetts Amherst, USA, and Sonia Flores, Ph.D., University of Colorado, USA
Dr. Sonia Flores, a member of the NIH working committee to end sexual harassment in science, will be answering audience questions. Questions may be anonymously submitted to bit.ly/PowerDynamicsSfRBM. This event is free and open to all SfRBM attendees. A salad bar lunch will be provided.
2:30 pm - 4:15 pm
Oral Presentations from Submitted Abstracts
3 concurrent sessions
4:15 pm - 6:45 pm
Formal Poster Presentations
9:00 pm - 11:00 pm
Hospitality
7:00 am - 6:30 pm
Registration/Information Desk
SUNRISE FREE RADICAL SCHOOL
8:00 am - 9:00 am
Back to the Basics
Chairs: Kimberly Dunham-Snary, Ph.D., Queen's University, Canada and Carola Neumann, MD, University of Pittsburgh, USA
8:00 am - 8:30 am
Redox Signaling and Mitochondrial Biogenesis in Skeletal Muscle
David Hood, Ph.D., York University, Canada
8:30 am - 9:00 am
Mitochondrial Calcium and ROS in Muscle Health
Jyoti Jaiswal, Ph.D., George Washington University, USA
PLENARY SESSION 5
9:30 am - 12:00 pm
Redox Signaling in Exercise Adaptation
Chairs: Siobhan Craige, Ph.D., Virginia Tech, USA and David Marcinek, Ph.D., University of Washington, USA
Exercise is one of the most powerful strategies to prevent age-related chronic diseases and improve healthspan. Reactive oxygen species produced during exercise are critical mediators of the adaptive responses to physical activity. However, the mechanisms by which redox dependent signaling alters adaptive processes and affects systemic responses to exercise remain largely unknown. A more complete understanding of the sources of oxidant production, the relative effects on redox status, and the local and systemic redox signaling in response to exercise is important for designing strategies to exploit the beneficial effects of exercise for the prevention and reversal of many chronic conditions.
9:30 am - 10:00 am
Redox Responses to Acute and Regular Exercise are Influenced by Age and Sex in Humans
Tinna Traustadottir, Ph.D., Northern Arizona University, USA
10:00 am - 10:30 am
EcSOD in the Health Benefits of Exercise
Zhen Yan, Ph.D., University of Virginia School of Medicine, USA
10:30 am - 11:00 am
Break
11:00 am - 11:30 am
Redox Proteomics and Mitochondrial Dynamis in Skeletal Muscle
Brian McDonagh, Ph.D., National University of Ireland Galway, Ireland
11:30 am - 12:00 pm
Liver Macrophages Regulate the Antioxidant Response
Valerio Azzimato, Ph.D., Karolinska Institutet, Sweden
12:00 pm - 12:30 pm
New Member Welcome Meeting
12:00 pm - 2:30 pm
Lunch
Attendees on own
2:30 pm - 4:15 pm
Oral Presentations from Submitted Abstracts
3 concurrent sessions
4:15 pm - 6:45 pm
Formal Poster Presentations
7:30 pm - 9:30 pm
Closing Awards Banquet
9:30 pm - 11:00 pm
Hospitality
SfRBM 2019 officially adjourns after the Closing Awards Banquet on Saturday, November 23.
8365 Keystone Crossing
Suite 107
Indianapolis, IN 46240
(317) 205-9482 PHONE
(317) 205-9481 FAX
info@sfrbm.org
® Copyright 2024 Society for Redox Biology and Medicine
