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11:00 am - 8:00 pm
Registration/Information Desk
PRE-CONFERENCE SESSION: Academic Entrepreneurship—Chapter 1: The Ins and Outs of Developing a Valuable Commercial Product
Separate registration required
Chairs: Carola Neumann, MD - University of Pittsburgh and Marcelo Bonini, PhD - Northwestern University
Join SfRBM for a special session highlighting the trials, tribulations and successes of drug development in an academic setting. Hear redox investigators share their experiences identifying drug targets, developing compounds, conducting basic research, obtaining funding from private and public sources and clinical trials. Learn approaches and techniques that may be helpful in your own future potential drug development projects.
1:00 pm - 1:10 pm
Introduction
Carola Neumann, MD - University of Pittsburgh
1:10 pm - 1:55 pm
Taking a PRDX3 Inhibitor from the Bench to a Positive Phase 1 Trial
Brian Cunniff, PhD - University of Vermont
1:55 pm - 2:15 pm
Development of a GLRX Protein to Treat Lung Fibrosis
Yvonne Janssen-Heininger, PhD - University of Vermont
2:15 pm - 2:35 pm
Commercialization of Research Reagents to Promote Innovation and Discovery in Thiol Biology
Cristina Furdui, PhD & Leslie Poole, PhD - Wake Forest School of Medicine
2:35 pm - 2:55 pm
Break
2:55 pm - 3:15 pm
Development of Nitro-Fatty Acids (NFAs) for Chronic Kidney Disease
Francisco Schopfer, PhD, MBA - University of Pittsburgh
3:15 pm - 3:30 pm
Developing an Anti-Cancer Agent RAD51 Inhibitor as a Therapeutic
Carola Neumann, MD - University of Pittsburgh
3:30 pm - 4:00 pm
Panel Discussion / Q&A
ANNUAL CONFERENCE BEGINS
4:45 pm - 4:55 pm
Chairs & President's Welcome
PLENARY SESSION
Chairs: Rafael Radi, MD, PhD - Universidad de la República, Uruguay & Ohara Augusto, PhD - University of São Paulo, Brazil
4:55 pm - 5:40 pm
Signaling through Hydrogen Sulfide: A Redox Metabolic Paradigm
Ruma Banerjee, PhD - University of Michigan
5:40 pm - 6:00 pm
Journal Update
Kelvin Davies, PhD, FRBM Co-Editor in Chief
Chris Kevil, PhD, Redox Biology Co-Editor in Chief
Eric Kelley, PhD, Advances in Redox Research Co-Editor in Chief
Rafael Radi, MD, PhD, Redox Biochemistry & Chemistry Co-Editor in Chief
6:00 pm - 6:30 pm
SfRBM Lifetime Achievement Award Talk: Radicals and Redox Biology: A Journey of Discovery
Christine Winterbourn, PhD - University of Otago Christchurch
6:30 pm - 8:00 pm
Opening Reception
Harbor Lawn at the Westin Savannah Harbor
7:00 am - 6:00 pm
Registration/Information Desk
CORE CONCEPTS IN REDOX BIOLOGY
Chairs: Matthew Ryan Smith, PhD - Emory University, Adam Case, PhD - Texas A&M University, and Ginger Milne, PhD - Vanderbilt University Medical Center
8:00 am - 8:30 am
Introduction to Reactive Oxygen Species
Carola Neumann, MD - University of Pittsburgh
8:30 am - 9:00 am
NADPH Oxidases
Patrick Pagano, PhD - University of Pittsburgh
9:00 am - 9:05 am
Sponsor Spotlight - RS Oncology
Brian Cunniff, PhD - University of Vermont
PLENARY SESSION
Chair: Albert van der Vliet, PhD - University of Vermont
9:05 am - 9:45 am
Structure-function Relationships of NOX NADPH Oxidases and Related Enzymes
Andrea Mattevi, PhD - University of Pavia
9:45 am - 10:15 am
Break
SYMPOSIA SESSION 1: New Aspects of Redox-active Sulfur and Sulfide in Health and Disease
Chairs: Hozumi Motohashi, MD, PhD - Tohoku University and Melanie Madhani, PhD - University of Birmingham
Our understanding of hydrogen sulfide (H2S) and related derivatives such as persulfides (RSSH/RSS-) have rapidly advanced. This symposium will provide an update on new aspects of redox biology that is governed by redox-active sulfur and sulfide containing molecules, with a special focus on chemical tools for understanding reactive sulfur and sulfide species to molecular signalling and biological functions.
10:15 am - 10:45 pm
Chemical Tools for Understanding Reactive Sulfur Species
Ming Xian, PhD - Brown University
10:45 am - 11:15 am
Sulfur Biology in Cell Metabolism
Takaaki Akaike, MD, PhD, Tohoku University - Japan
11:15 am - 11:35 am
Supersulfide Synthesis in Mitochondria is Essential for Mitochondrially-Encoded Protein Expression
Shohei Murakami - Tohoku University
11:35 am - 11:55 am
Aspects of Redox-active Sulfur and Sulfide in Health and Disease
Gopi Kolluru - LSU Health Shreveport
11:55 am - 12:15 pm
Gut H2S Metabolism Influences Brain Functions
Roshan Kumar - University of Michigan
SYMPOSIA SESSION 2: Beyond the Cell: Oxidation of the Extracellular Matrix in Physiology and Disease
Chairs: Michael J Davies, D.Phil - University of Copenhagen and Andreia Chignalia, PhD - University of Arizona
Oxidation of extracellular matrix and glycocalyx components is critical to physiology, but also drives many diseases. The switch from physiological to pathophysiological oxidation arises from differences in reaction mechanisms, altered redox equilibria, defense mechanisms and the abundance and turnover of extracellular species. This session will examine modifications induced by oxidants, from chemistry to bedside, with a particular emphasis on the lung and cardiovascular disease.
10:15 am - 10:45 pm
Bromine-dependent Oxidation in Pulmonary ECM Biology and Remodeling
Albert van der Vliet, PhD - University of Vermont
10:45 am - 11:15 am
Modifications to the Structure of Arterial Wall as a Driver of Cardiovascular Disease
Michael J. Davies, DPhil - University of Copenhagen
11:15 am - 11:35 am
Extracellular Superoxide Dismutase Content Modulates Hypoxia-induced Platelet Activation, Interstitial Macrophage Accumulation/Reprogramming and Hyaluronan Binding
Caitlin Lewis - University of Colorado
11:35 am - 11:55 am
Interaction Between Protein Disulfide Isomerase-A1 and Enolase1 as a Potential Mechanism Protecting Against Aortic Disease
Sara Ventura - The Heart Institute - FMUSP
11:55 am - 12:15 pm
Redox Regulation of Platelet-Neutophil Interactions in Staphylococcus Aureus Pneumonia
Christina Sul - University of Colorado Anschutz Medical Center
12:15 pm - 2:15 pm
Lunch on Own @ Hotel or Downtown Savannah
1:00 pm - 1:45 pm
Professional Development Session 1: Speed-Dating Your Future Career
Participants will learn more about potential career options by spending time with representatives from academia, publishing, industry, NIH, and university administration in smaller, roundtable formats. Box lunch included.
SYMPOSIA SESSION 3: Unveiling the Therapeutic Potential: Exploring Redox Signaling from Fundamentals to Drug Targets
Chairs: Nathalie Grandvaux, PhD - University of Montreal and Masuko Ushio-Fukai, PhD, Augusta University
At the center of redox signaling are oxidoreductive chemical reactions involving low and moderate localized levels of reactive oxygen species and reductants that modify the thiol-side chain of cysteinyl residues in proteins. In turn, these post-translational modifications cause a spectrum of structural alterations that allow reactive oxygen species production to be coupled to functional outputs in the cell. This session discusses timely and exciting advances in the redox field that highlight the compartmentalization of redox signaling events and recent translational efforts to develop small molecules that target cysteines and other nucleophilic residues.
2:15 pm - 2:45 pm
Proton Pump Inhibitors: Unconventional Targeting of Protein Thiols in Unexpected Places
Tobias Dick, PhD - German Cancer Research Center
2:45 pm - 3:15 pm
Nucleophilic Covalent Ligand Discovery for the Cysteine Redoxome
Kate Caroll, PhD - The Herbert Werthheim UF Scripps Institute for Biomedical Innovation and Technology
3:15 pm - 3:35 pm
Peroxiredoxin 3 Supports Tumor Cell Proliferation, Migration, Mitochondrial Function and Metastatic Gene Expression
Victoria Gibson - University of Vermont
3:35 pm - 3:55 pm
Zinc-mediated Inhibition of Soluble Epoxide Hydrolase Promotes Pulmonary Hypertension
Stanley Buffonge - Queen Mary University of London
3:55 pm - 4:15 pm
Mitochondrial Electron Transport Chain Inhibition Suppresses NRF2 Expression in NSCLC
Chang Jiang - H. Lee Moffitt Cancer Center and Research Institute
SYMPOSIA SESSION 4: Nitric Oxide and Guanilyl Cyclase: Insights and Implications for Human Cardiovascular Pathophysiology
Chairs: Francis Miller Jr - Vanderbilt University and Brant Isakson, PhD - University of Virginia
Recent advancements in single-cell analysis techniques and the development of cell-specific knockout (KO) and knock-in (KI) mice models have paved the way for groundbreaking discoveries on unexpected roles of nitric oxide (NO) in systemic redox metabolism and cell differentiation. The Isakson Lab discovered the critical role of non-erythrocytic hemoglobin in myoendothelial junctions, acting as a NO scavenger and thereby controlling vascular NO bioavailability and vasodilation under normoxic conditions. Utilizing endothelial cell (EC)-specific KO his lab found that non-erythrocytic hemoglobin under hypoxic conditions is a nitrite reductase, and thereby regulates vascular tone and blood pressure. In recent unpublished investigations they employed EC-specific caveolin and eNOS KO mice, alongside human cells and single-cell sequencing from patients with adiposity. They identified a novel NO-mediated signaling pathway that orchestrates the trafficking of free fatty acids within and outside adipose tissue endothelial cells. This pathway plays a crucial role in regulating circulating lipids, offering new perspectives on the metabolic functions of NO. The Cortese-Krott lab research work recently revealed an unexpected role of red cell endothelial nitric oxide synthase (eNOS) for the control of blood pressure and cardioprotection. This function is distinct from the well-known role of EC eNOS, highlighting the importance of cell-specific approach to understand NO signaling. Moreover, the Cortese-krott lab recently generated erythroid cell-specific soluble guanylate cyclase (sGC) KO mice and found that red cell sGC is pivotal for early erythropoiesis and blood pressure control. This discovery reveal a novel role of NO-mediated sGC regulation in hematological and cardiovascular diseases, suggesting potential therapeutic targets. This session will provide a comprehensive overview of the cell-specific roles of NO/reactive species in redox metabolism and cell differentiation. Through cutting-edge research and innovative methodologies, attendees will gain insights into the complex regulatory mechanisms of reactive species and their implications for human health.
2:15 pm - 2:45 pm
Nitric Oxide-Mediated Control of Lipids in Adipose Endothelial Cells
Brant Isakson, PhD - University of Virginia
2:45 pm - 3:15 pm
Erythroid-cell Soluble Guanylate Cyclase Controls Erythroid Cell Differentiation and Blood Pressure in Vivo
Miriam M. Cortese-Krott, PhD - University of Düsseldorf
3:15 pm - 3:35 pm
CYB5R3 Regulates Endothelial Store-Operated Ca2+ Signaling via NO-dependent Mechanism
Mate Katona - University of Pittsburgh
3:35 pm - 3:55 pm
Phosphodiesterase 9A Inhibition Improves Coronary Microvascular Disease and Diastolic Dysfunction in a HFpEF Model via PRDX5-Linked Antioxidant Mechanisms
Katie Anne Fopiano - Medical College of Georgia, Augusta University
3:55 pm - 4:15 pm
Nitrated Fatty Acids as Early Modulators of Monocyte Function in Atherosclerosis
Maria Victoria Gutierrez - National University of Cordoba, CIBICI-CONICET
4:15 pm - 6:15 pm
Poster Presentations
4:30 pm - 5:30 pm
Featured Poster Symposia (10)
6:30 pm - 8:30 pm
FRBM / Redox Biology Editorial Meetings & Reception
6:30 pm - 8:30 pm
Opening Doors Event: Recognizing and Resisting Imposter Syndrome: Research-based Insights and Strategies That Work
This session will address the pervasive issue of imposter syndrome within the academic community. It will feature a series of small group discussions/ working groups, facilitated by committee members and volunteers who can provide valuable perspectives, hindsight, and support. Facilitated groups include Woman-Identifying, Racialized Minority, or LGBTQIA+, Trainees (Graduate Students and Postdocs), Pre-Tenure/Tenure-Track/Early Career Academics and English as a Second Language. The primary goal of this workshop is to create a sense of community and equip participants with strategies to combat imposter syndrome.
7:00 am - 6:00 pm
Registration/Information Desk
CORE CONCEPTS IN REDOX BIOLOGY
Chairs: Matthew Ryan Smith, PhD - Emory University, Adam Case, PhD - Texas A&M University, and Ginger Milne, PhD - Vanderbilt University Medical Center
8:00 am - 8:30 am
A Short History of Redox-Sensitive Fluorescent Proteins
Tobias Dick, PhD - German Cancer Research Center
8:30 am - 9:00 am
Endoplasmic Reticulum Redox Signaling and Stress
Carolyn Sevier, PhD - Cornell University
PLENARY SESSION
Chair: Rebecca Oberley-Deegan, PhD - University of Nebraska
9:00 am - 9:45 am
Exploiting Fundamental Differences in Cancer Cell Redox Metabolism for Enhancing Therapeutic Outcomes
Oberley Lectureship in Cancer and Aging (Inaugural Lectureship)
Doug Spitz, PhD - University of Iowa
9:45 am - 10:15 am
Break
SYMPOSIA SESSION 5: DNA Damage and Genomic Instability
Chairs: Carola Neumann, MD - University of Pittsburgh and Albert van der Vliet, PhD - University of Vermont
Oxidative DNA damage is a constant challenge of the genome, arising from exposure to reactive oxygen species (ROS). These can come from multiple external and internal sources, including but not limited to endogenous chemical processes through the cells' own metabolism and enzymatic activity, inflammatory processes, toxins, or ionizing radiation. When persistent, damage harbors the risk of disrupting cellular function and causing mutation. Naturally, living organisms have evolved very efficient repair mechanisms. Mitochondrial overproduction of ROS is the underlying cause for oxidative stress-related cell damage and its role in mutagenesis has long been postulated. On the other hand, exploiting excessive oxidative DNA damage that promote cancer cell death has emerged as promising anti-cancer therapy. This session will shed some light on our current understandings on the role of ROS-induced DMA damage in disease.
10:15 am - 10:45 pm
Targeting Redox Vulnerabilities for Cancer Precision Medicine
Urbain Weyemi, PhD - National Institutes of Health
10:45 am - 11:15 am
Differential Damage, Signaling, and Cell Fate Downstream of Local Oxidant Production
Tobias Dansen, PhD - University Medical Center Utrecht
11:15 am - 11:35 am
Baseline Oxygen Level Affects the Transcriptional and Metabolic Responses of Prostate Cancer Cells to Hypoxia
Ricardo Alva - Brock University
11:35 am - 11:55 am
Nitroalkenes Exploit Dependence on Autophagy-Lysosome Pathway in PARPi-Resistant Triple Negative Breast Cancer
Lisa Hong - University of Pittsburgh
11:55 am - 12:15 pm
Oxidative DNA Damage and Chromatin Structure: Understanding the Influences on the Redox Mutational Landscape of Human Cancer
Cameron Cordero - University of Vermont
SYMPOSIA SESSION 6: Recent Advances in Heme Proteins and Redox Signaling in Vascular Biology and Beyond
Chairs: Jesus Tejero, PhD - University of Pittsburgh and David Jourd'heuil, PhD, F-SfRBM - University of Pittsburgh, Albany Medical College
Heme proteins are pivotal for the biology of reactive oxygen and nitrogen species (ROS/RNS). Novel vertebrate heme proteins have been discovered in the last 25 years, and others such as hemoglobin have been found in unsuspected tissues and cellular locations, challenging our existing knowledge. In this session we focus on recent advances that defy the general conceptions about the role of heme proteins in chemical biology, from development to vascular biology and beyond.
10:15 am - 10:45 pm
Cytoglobin Role in Cilia Function and Nitric Oxide Signaling
Paola Corti, PhD - University of Maryland
10:45 am - 11:15 am
Cytoglobin B5 Reductase Heme-Dependent and Independent Signaling in Vascular Biology
Adam Straub, PhD - University of Pittsburgh
11:15 am - 11:35 am
Novel Role of Copper Transport Proteins in Oxidative Stress-Dependent Brain Endothelial Barrier Dysfunction and Inflammation Associated with Alzheimer's Disease
Md. Selim Hossain - Medical College of Georgia at Augusta University
11:35 am - 11:55 am
Redox Regulation of Lung Endothelial PERK, Unfolded Protein Response (UPR) and Proliferation; Selective NOX1 Inhibition as a Potential Therapy for PAH
Christian Goossen, University of Pittsburgh
11:55 am - 12:15 pm
Hemoglobin Alpha is a Redox Sensitive Regulator of T-Lymphocytes
Emily Reed - Texas A&M University
12:15 pm - 2:15 pm
Lunch on Own @ Hotel of Downtown Savannah
1:00 pm - 1:45 pm
Professional Development Session 2: Finding a Home: Funding Opportunities for Redox Biologists at NIGMS
Featured speaker will be Dr. Charles Ansong, NIGMS Program Director. Dr. Ansong administers a research portfolio in the areas of redox biology, trace metals, bioenergetics and oxidative stress. Learn what programs and funding opportunities are available at NIGMS. Box lunch included.
SYMPOSIA SESSION 7: Redox Regulation of the Epigenome (presented by the Trainee Council)
Chairs: Evan DeVallance, PhD - West Virginia University and Nirmal Kumar, PhD - University of North Dakota
Epigenetics and epigenetic sequencing techniques have been at the leading edge of science for the past decade. Recent evidence has revealed redox-mediated signaling as well as direct redox modifications of chromatin. This symposium will touch on cutting-edge discoveries as to how redox regulation of the epigenome contributes to health and disease across organ systems.
2:15 pm - 2:45 pm
Early Life ROS as Modulator of Lifespan and Age-Associated Diseases
Ursala Jakob, PhD - University of Michigan
2:45 pm - 3:15 pm
SOD Mimia and Methylation of Lifespan and Age-Associated Diseases
Rebecca Oberley-Deegan, PhD - University of Nebraska Medical Center
3:15 pm - 3:35 pm
Fine Particulate Matter Induces Glycolysis in Lung Epithelial Cells via m6A Methylation of HIF-1α
Yishu Dong - Florida International University
3:35 pm - 3:55 pm
Nitro-oleic acid redirects energy substrate utilization to shift macrophage polarization
Emily Stevenson - University of Pittsburgh
3:55 pm - 4:15 pm
Investigating the Metabolic and Epigenetic Roles of PBK in Pulmonary Arterial Hypertension
Zachary Brown - Augusta University
SYMPOSIA SESSION 8: Lipidomics, Oxidative Stress, and Relevance in Human Health and Disease
Chairs: Andres Trostchansky, PhD - Universidad de la República, Uruguay and Stacy Gelhaus Wendell - PhD, University of Pittsburgh
The role of bioactive lipids in inflammatory processes, their identification, detection, and quantification are relevant areas of study for the biochemistry and physiology of inflammatory processes. They are related to health disease processes. It is intended to address the current state of the art of methodologies applied to the study of lipid mediators in vitro, cellular systems, and human samples. In particular, the latest advances in mass spectrometry techniques, HPLC, as well as in the transcriptomic, proteomic, and metabolomic analysis of signaling pathways associated with changes in the levels of lipid mediators and their role in pathologies such as cardiovascular, pulmonary, and neurodegenerative diseases. Electrophilic mediators exert signaling actions by covalently modifying key proteins and modulating relevant signaling pathways. Among these lipids, nitrated fatty acids, ketones, and epoxides derived from enzymatic and nonenzymatic sources are part of the activation and regulation of intracellular cascades. The formation and biological activities of the specialized pro-resolving lipid mediators (SPM) is a relevant area of study being highly discussed in academia and literature. SPMs have been shown to exert protective effects on different pathologies, mainly those associated with inflammatory processes. The symposium will address the role that lipid-derived bioactive compounds play in the development and treatment of human diseases, from their formation, and signaling to their final protective effects. The primary objective is to bring together experts and researchers from diverse disciplines to discuss and share insights into the dynamic interplay between lipidomics, oxidative stress, and their implications for human health and disease.
2:15 pm - 2:45 pm
The Role of 15-Oxo-Lipoxin A4 and Other Fatty Acid Electrophiles in Receptor-Independent Inflammation Resolution
Stacy L. Gelhaus, PhD - University of Pittsburgh
2:45 pm - 3:15 pm
Exploring Dysregulated Redox Pathways in ALS through Lipidomoics and Oxidized Lipid Profiling
Sayuri Miyamoto, PhD - University of São Paulo
3:15 pm - 3:35 pm
Radiation-induced Glioblastoma Extracellular Vesicles Containing 4HNE Promote Microglia-Mediated Neurotoxicity
Sara Macias Palacio - University of Kentucky
3:35 pm - 3:55 pm
Lipid Quality Control: Protection Of Stored Lipids From Oxidative Damage Is Mediated By Ferroptosis Suppressor Protein 1
Mike Lange - University of California, Berkeley
3:55 pm - 4:15 pm
A New Function of PUFA-Plasmalogens in Ferroptosis
Brian Kleiboeker - University of Pittsburgh
4:15 pm - 6:15 pm
Poster Presentation
4:30 pm - 5:30 pm
Featured Poster Symposia (10)
9:00 pm - 11:00 pm
Hospitality
Riverscape (Westin 2nd Floor)
7:00 am - 6:00 pm
Registration/Information Desk
CORE CONCEPTS IN REDOX BIOLOGY
Chairs: Matthew Ryan Smith, PhD - Emory University, Adam Case, PhD - Texas A&M University, and Ginger Milne, PhD - Vanderbilt University Medical Center
8:00 am - 8:30 am
Redox Metals in Biology
Zack Jarrell, PhD - Emory University
8:30 am - 9:00 am
Lipids in Redox Biology
Ginger Milne, PhD - Vanderbilt University
PLENARY SESSION
Chair: Phyllis Dennery, MD, F-SfRBM - Brown University
9:00 am - 9:45 am
Copper Redox Chemistry in Degenerative Diseases: From Alzheimer's to Cataract Disease
Liliana Quintanar, PhD - Center for Research and Advanced Studies
9:45 am - 10:15 am
Break
SYMPOSIA SESSION 9: Papers of the Year — FRBM, Redox Biology, ARRES, and RBC
Chairs: Alicia Kowaltowski, PhD - University of São Paulo, Brazil and Andres Trostchansky, PhD - University of the Republic, Uruguay
New for 2024! This symposia features the top published paper in each of SfRBM's 4 journals - Free Radical Biology and Medicine (FRBM), Redox Biology (RB), Advances in Redox Research (ARRES) and Redox Biochemistry & Chemistry (RBC) in calendar year 2023. The authors will present their high-impact research, which was nominated by the journal's editorial staff and selected by a special committee of both SfRBM and SFRR-Europe members.
10:15 am - 10:45 pm
Energy Substrate Metabolism, Mitochondrial Structure and Oxidative Stress After Cardiac Ischemia-Reperfusion in Mice Lacking UCP3
Ana Mata - Centro de Biología Molecular Severo Ochoa (CSIC/UAM), Spain
10:45 am - 11:15 am
Hydropersulfides (RSSH) Attenuate Doxorubicin-Induced Cardiotoxicity while Boosting its Anticancer Action
Chengximeng (Kelsey) Zhang, PhD - Johns Hopkins University
11:15 am - 11:35 am
Spectroelectrochemical Testing of a Proposed Mechanism for a Redox-Based Therapeutic Intervention: Ascorbate Treatment of Severe Paraquat Poisoning
Eunkyoung Kim - University of Maryland
11:45 am - 12:15 pm
Cross-linking Between Cysteine and Lysine, Tryptophan or Tyrosine in peptides and Proteins Treated with Hypochlorous Acid and Other Reactive Halogens
Nicholas Magon - University of Otago Christchurch
SYMPOSIA SESSION 10: Molecular Mitochondrial Interplay in Striated Muscle in Aging and Disease
Chairs: Johanna Lanner, PhD - Karolinska Institutet and Holly Van Remmen, PhD - Oklahoma Medical Research Fnd.
Cardiac and skeletal muscle (striated muscle) are metabolically demanding organs packed with mitochondria that are key for redox signaling and metabolic adaptation and the focus of this symposia. Mitochondrial dynamics and their interaction with other cell structures, particularly in relation to redox and Ca2+ homeostasis will be discussed, as well as insight into molecular clock mechanisms in muscle homeostasis and potential lifestyle interventions.
10:15 am - 10:45 pm
Mitochondrial Calcium and Redox Signaling in Striated Muscle
Gyorgy Hajnoczky, MD, PhD - Thomas Jefferson University
10:45 am - 11:15 am
The Aging Muscle Clock and Impacts on Mitochondria
Karyn Esser, PhD - University of Florida
11:15 am - 11:35 am
Sulfenylation of Drp1 in Endothelial Cells Couples VEGF-induced Redox Signaling and Glycolysis to Drive Angiogenesis
Sheela Nagarkoti - Medical College of Georgia at Augusta University
11:35 am - 11:55 am
Skeletal Muscle Metabolomics Reveal mtDNA- and Diet-Specific Metabolic Profiles in a Mouse Model of Diet-Induced Cardiometabolic Disease
Abhishek Shastry - Queen's University
11:55 am - 12:15 pm
Investigation of the Biological Function of the Double Localization of Prx1 in the Mitochondria of Saccharomyces Cerevisiae
Sophia B. Cozzo - University of São Paulo
12:15 pm - 2:15 pm
Lunch on Own @ Hotel or Downtown Savannah
1:00 pm - 1:45 pm
Professional Development Session: From Bench to Publication: Meet the Editors of Cell Reports & Redox Biology
Luca Gasparoli, PhD, Cell Press & Chris Kevil, PhD, Redox Biology
Moderated by Dr. Marcelo Bonini, this panel will include editors from Cell Reports and Redox Biology. Participants will learn what makes articles attractive to editors, obtain valuable tips and best practices advice for preparing your own manuscript and understand the different perspectives of scientific editors vs. professional editors. Box lunch included.
SYMPOSIA SESSION 11: Innovative Aspects of Blood Redox Biomarkers
Chairs: Cristina Furdui, PhD - Wake Forest University and Daniel Kim-Shapiro, PhD - Wake Forest University
Although blood is the most collected biospecimen to evaluate oxidative stress, its current usefulness for evaluating redox status is limited since it is prone to redox artifacts post-collection. The focus of this session will be on discussion of new approaches for preventing artifactual oxidation and loss of specimen integrity during sample processing and storage such that accurate analytical analyses are possible to allow for informed interpretation of patients’ redox metabolism. Speakers will also highlight new findings that relate redox biomarkers to disease.
2:15 pm - 2:45 pm
Biomarkers of Oxidative Stress: GSH/GSSG Redox Couple and Beyond
Dean P. Jones, PhD - Emory University
2:45 pm - 3:15 pm
Redox Trapping for Blood Preservation and Advancement of Clinical Care
Cristina M. Furdui, PhD - Wake Forest School of Medicine
3:15 pm - 3:35 pm
Alterations in Redox Homeostasis and Thiol Metabolism of Glioblastoma versus Normal Brain in Response to Treatment with Redox-Active Therapeutics
Kamal Shaik - Ivy Brain Tumor Center - Drexel
3:35 pm - 3:55 pm
Catalase, Azide, and Peroxide Reaction Produces Nitroxyl
Weijun Gao - Wake Forest University
3:55 pm - 4:15 pm
EPR Imaging as a Tool for Biomedical Research and Clinical Applications: Acute lung Injury
Hanan Elajaili - University of Colorado
SYMPOSIA SESSION 12: A Mito-centric View in Healthy Aging: Redox Homeostasis and Lifestyle Interventions
Chairs: Mari Carmen Gomez-Cabrera, PhD - University of Valencia and Alicia Kowaltowski, PhD - University of São Paulo, Brazil
A fundamental challenge for the medical-scientific community is to enable aging with the greatest independence and quality of life possible. In this sense, functional performance in older people is the factor most strongly related to quality of life and the risk of hospitalization, permanent institutionalization, use of social and health resources, and death.
Despite advanced age, some persons remain vigorous, while others have a gradual functional decline in the absence of apparent diseases. Unlocking the mechanistic foundation of age-associated diseases requires understanding the cellular and molecular mechanisms underlying organic deterioration, both during normal aging and in chronic diseases or unhealthy lifestyles. One of the twelve hallmarks of aging is mitochondrial dysfunction. Mitochondria produce most of the cellular ATP and are also involved in other essential cellular functions such as reactive oxygen species signaling, calcium homeostasis, inflammation, and even cell death. Numerous studies have described damage to mitochondria in aged cells and organisms, including humans.
Emerging evidence suggests that reduced skeletal muscle oxidative capacity and efficiency underlie the etiology of mobility loss, diminished muscle strength, and performance in older adults. Moreover, inefficient and dysfunctional mitochondria in the central nervous system have been implicated in neurodegenerative diseases. However, the factors that are associated with mitochondrial dysfunction have not been well characterized and no data connects age-related changes in mitochondrial dysfunction with phenotypic and pathological changes in aging.
In this symposium, we aim to understand the fundamental aspects of age-associated mitochondrial dysfunction, its relation with the functional status of individuals, and the role of different types of interventions in the maintenance of these organelles.
2:15 pm - 2:45 pm
Exercise Training Promotes a Mitochondrial "Healthy Aging" Signature in Skeletal Muscle
Maria Carmen Gomez-Cabrera, PhD - University of Valencia
2:45 pm - 3:15 pm
Mitochondria and mtDNA in Healthy Aging
Jose Antonio Enriquez - Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Spain
3:15 pm - 3:35 pm
Inducible and Reversible SOD2 Knockdown in Mouse Skeletal Muscle Drives Impaired Pyruvate Oxidation and Metabolic Inflexibility
Ethan Ostrom - University of Washington
3:35 pm - 3:55 pm
Decoding Mitophagy Suppression by Phosphorylated Tau in a Caenorhabditis Elegans Model of Alzheimer's Disease
Upasana Ganguly - University of Rochester
3:55 pm - 4:15 pm
Sex-Dependent Effects of Gut Microbiome-Derived Metabolite δ-Valerobetaine on Aging
Gahyun Lim - Emory University
4:15 pm - 6:15 pm
Poster Presentation
4:30 pm - 5:30 pm
Featured Poster Symposia (10)
7:00 pm - 8:30 pm
Closing Banquet & Awards Ceremony
9:00 pm - 11:00 pm
Hospitality
Riverscape (Westin 2nd Floor)
SfRBM 2024 officially adjourns after the Closing Awards Banquet on Saturday, November 23.
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