Program/Schedule

All times are listed in Central Time (CT)

Wednesday, June 15

7:30 am
Registration & Poster set up

8:00 am - 8:15 am
Welcome
George Weiner, MD, Director, HCCC, University of Iowa Hospitals and Clinics

8:15 am - 9:45 am
Holden Comprehensive Cancer Center Presentations (15 minutes each)

Pharmacological ascorbate selectively enhances NSCLC response to immune checkpoint inhibitor therapy and chemo-radiation in an iron-dependent manner
Amira Zaher, Graduate Research Assistant

Challenges and Opportunities Implementing Evidence-Based Intervention
Eliza Steere, Graduate Research Assistant

Resistance to Pharmacological Ascorbate in Pancreatic Cancer
Amanda Pope, Graduate Research Assistant

Enhancement of NK cell mediated ADCC using anti-CD3 based bispecific antibody in multiple myeloma
Jyoti Arora, Graduate Research Assistant

Identifying Patient Requirements for Personal Health Record Software for Neuroendocrine Tumors
Michael O’Rourke, Ph.D.

Restore Functional Progesterone Receptor Expression in Endometrial Cancer
Sarina Murray, Graduate Research Assistant

9:45 am - 10:00 am
Break

10:00 am - 11:30 am
Holden Comprehensive Cancer Center Presentations (15 minutes each)

The Influence of SUMOylation on Transcriptional Regulation by ETV1 in Breast Cancer
Zhijie Li, Graduate Research Assistant

Augmenting chemotherapy with low-dose decitabine through an immune-independent mechanism
Wade Gutierrez, Graduate Research Assistant

A Genetically Encoded Sensor for Studying Serotonin Metabolism in Neuroendocrine Cancer
Dane Tow, Student Laboratory Assistant

Ferritin Heavy Chain (Ft-H) Limits Iron Availability and Promotes Replication Stress in Lung Cancer Cell
Khaliunaa Bayanbold, Graduate Research Assistant

How Collaboration, Focus, and Determination Brought About Policy, Systems, and Environmental (PSE) Change with The Gail Orcutt School Radon Safety Bill
Liz Orton, Program Coordinator for Iowa Cancer Consortium

Phase 0 study to evaluate role of T cells in NK cell mediated antibody dependent cellular cytotoxicity (ADCC) of lymphoma
Sabrish Ayyappan, MD

11:30 am - 1:30 pm
Lunch & Visit Posters 

1:30 pm - 5:30 pm
Joint Session: Cancer, Redox Biology and Therapy
Chairs: Douglas Spitz, PhD, The University of Iowa and Claudia Oliva, PhD, The University of Iowa
Location: Coral Ballroom AB

1:30 pm - 1:55 pm
Exploiting Redox Biology with Pharmacological Ascorbate to Enhance Chemoradiation Response
Douglas Spitz, PhD, The University of Iowa

1:55 pm - 2:20 pm
Understanding and Preventing Cardiac Damage During Radiotherapy
Barry London, MD, PhD, HCCC, The University of Iowa

2:20 pm - 2:30 pm
Break & Visit Posters
Location: Coral Ballroom CDE

2:30 pm - 2:55 pm
Chlorpromazine Inhibition of COX4-1 Containing Cytochrome C Oxidase to Treat Chemoresistant Glioma
Corinne Griguer, PhD, HCCC, The University of Iowa

2:55 pm - 3:20 pm
Hydrogen Peroxide Disrupts Adipocyte Differentiation: a Late Opportunity for Antioxidants against Fibrosis after Radiotherapy?
Mitchell Coleman, PhD, HCCC, The University of Iowa

3:20 pm - 3:30 pm
Break & Visit Posters
Location: Coral Ballroom CDE

3:30 pm - 4:30 pm
Cancer Colloquium: Role of Reactive Oxygen Species in the Cytotoxicity of Selected Anticancer Compounds
James Doroshow, MD, National Cancer Institute

4:30 pm - 5:30 pm
Translational Oncology Roundtables

Track 1: Clinical Development and Medical Applications of SOD Mimetic Drugs
Douglas Spitz, PhD, The University of Iowa, Rebecca Oberley-Deegan, PhD, University of Nebraska Medical Center, John Buatti, MD, The University of Iowa
Oakdale 1&2

Track 2: Clinical Studies Employing Vitamin C Infusion, or Pharmacological Ascorbate Administration, as an Adjuvant to Chemo-Radiotherapy
Garry Buettner, PhD, F-SFRBM, The University of Iowa, Bryan Allen, MD, PhD, The University of Iowa, Varun Monga, MD, The University of Iowa
Coral Balroom A-B

5:30 pm - 6:30 pm
Wine & Cheese Social
Location: Hyatt Hotel, Salon C-E

Dinner on your own (Recommend Iowa River Landing area)

Thursday, June 16

7:00 am - 7:50 am
Breakfast

7:30 am
Registration and Poster Set Up

8:00 am - 1:15 pm
Session Two: Redox Signaling and Disease Mechanisms
Chairs: Bryan Allen, MD, PhD, The University of Iowa, and Corinne Griguer, PhD, The University of Iowa
Location: Coral Ballroom AB

7:50 am - 8:00 am
Welcome and Opening Remarks
Douglas Spitz, PhD, The University of Iowa

8:00 am - 8:25 am
Protecting Mitochondrial Function to Prevent (Cardio)vascular Toxicity of Radiotherapy
Isabella Grumbach, MD, PhD, HCCC, The University of Iowa

8:25 am - 8:50 am
Redox Signaling of Cell Proliferation in Health and Disease
Prabhat Goswami, PhD, The University of Iowa

8:50 am - 9:50 am
Special Seminar: Peroxiredoxin Structures and Dynamics Tailored to Their Roles in Redox Signaling and Defense
Leslie Poole, PhD, Wake Forest University School of Medicine

9:50 am - 10:00 am
Break & Visit Posters
Location: Coral Ballroom CDE

10:00 am - 10:25 am
Lipolysis Regulates the Chronological Life Span of Aging Fibroblasts
Ehab Sarsour, PhD, Kansas City University of Medicine and Biosciences

10:25 am - 10:50 am
Heme-Induced Elevation in Circulating Xanthine Oxidase is a Protective Response
Eric Kelley, PhD, West Virginia University

10:50 am - 11:15 am
Break & Visit Posters
Location: Coral Ballroom CDE

11:15 pm - 12:15 pm
Plenary Lecture: Redox Signaling During Hypoxia in Mammalian Cells
Paul Schumacker, PhD, Northwestern University

12:15 pm - 1:15 pm
Lunch Break & Visit Posters

1:15 pm - 4:30 pm
Session Three: Oxygen Biology and Redox Balance
Chairs: Ehab H. Sarsour, PhD, Kansas City University of Medicine and Biosciences and Rebecca Deegan-Oberley, PhD, University of Nebraska Medical Center
Location: Coral Ballroom AB

1:15 pm - 1:40 pm
Mitochondrial Superoxide in T-lymphocytes: Implications for Post-Traumatic Stress Disorder
Adam J. Case, PhD, Texas A&M University

1:40 pm - 2:05 pm
Targeting Mitochondrial Redox State to Enhance Prostate Cancer Outcome
Luksana Chaiswing, PhD, University of Kentucky

2:05 pm - 2:30 pm
Break & Visit Posters
Location: Coral Ballroom CDE

2:30 pm - 2:55 pm
The Epigenetic and Morphogenetic Effects of Molecular Oxygen and its Derived Reactive Species in Development
Michael Hitchler, PhD, Kaiser Permanente

2:55 pm - 3:20 pm
Succinate Accumulation Links Mitochondrial MnSOD Depletion to Aberrant Nuclear DNA Methylation and Altered Cell Fate
Frederick Domann, PhD, The University of Iowa

3:20 pm - 4:20 pm
Keynote Address: Implications of Cyclic Hypoxia for Tumor Metabolism and Response to Therapy
Mark Dewhirst, DVM, PhD, Duke University

4:20 pm - 4:30 pm
Closing Remarks
Douglas Spitz, PhD, The University of Iowa

4:30 pm - 6:30 pm
Networking Event at The Hyatt
*Cash Bar
Location: Upper East Terrace

6:30 pm
Closing Banquet Dinner Party: The Life and Times of Redox Pioneers Larry and Terry Oberley
Kathleen Oberley, The University of Iowa