Conference Program

Daily Schedules

Wednesday
  Pre-Conference Session
Thursday
Friday
  Opening Doors Event
Saturday

WEDNESDAY, NOVEMBER 16, 2022

10:00 am - 6:30 pm
Registration/Information Desk

PRE-CONFERENCE SESSION*
1:00 pm - 5:00 pm
New Horizons in Redox Biology: Mitochondria and Thiols
Chairs: Holly Van Remmen, PhD, Oklahoma Medical Research Fnd, USA and Francisco Laurindo, MD, Heart Institute (INCOR), University of São Paulo School of Medicine, Brazil
*Additional cost - requires registration ($75 for senior scientist / $50 for trainee)

This new conference session will feature outstanding early to mid-career investigators presenting new findings in redox biology, focusing on mitochondrial & thiol research and related disease states. The symposia will combine talks with informative panel discussions and audience interaction. SfRBM plans to incorporate this session into future conferences, changing up the themes each year.  Make sure you get to Orlando by mid-day Wednesday to take part!

1:00 pm - 1:05 pm
Welcome

1:05 pm - 1:30 pm
A Mitochondrial Complex I Thiol Switch and Hypoxic Avoidance
Andrew Wojtovich, PhD, University of Rochester

1:30 pm - 1:55 pm
Mitochondrial Druggable Targets that Control VSMC Phenotype
Alejandra San Martin, PhD, Emory University

1:55 pm - 2:20 pm
Mitochondrial-Encoded Microproteins and Metabolic Adaptation
Changhan Lee, PhD, University of Southern California

2:20 pm - 2:45 pm
Panel Q & A / Moderated Discussion

2:45 pm - 3:05 pm
Break

3:05 pm - 3:30 pm
Understanding Dynamic Changes in Mitochondrial NADPH in Response to Stress
Hadley Sikes, PhD, MIT

3:30 pm - 3:55 pm
Hydrogen Sulfide and Neuroprotection: Modern Roles of an Ancient Messenger Molecule
Bindu Paul, PhD, Johns Hopkins University

3:55 pm - 4:20 pm
Redox Regulation of Protein Tyrosine Phosphatases and the Control of Cell Signaling
Ben Boivin, PhD, SUNY Polytechnic Institute

4:20 pm - 4:45 pm
Panel Q & A / Moderated Discussion

6:00 pm - 8:45 pm
Welcome Reception

6:00 pm - 8:15 pm
Trainee Welcome Event


THURSDAY, NOVEMBER 17, 2022

7:00 am - 6:30 pm
Registration/Information Desk

ANNUAL CONFERENCE BEGINS

SUNRISE FREE RADICAL SCHOOL
Back to Basics
Chairs: Kimberly Dunham-Snary, PhD, Queen’s University, Canada and Adam Case, PhD, Texas A&M University, USA

8:00 am - 8:30 am
Sources of ROS: Mitochondria
Andrew Wojtovich, PhD, University of Rochester Medical Center, USA

8:30 am - 9:00 am
Cellular Metabolism and its Regulatory Effects
Samantha Giordano-Mooga, PhD, University of Alabama Birmingham, USA

PLENARY SESSION 1
9:30 am - 12:00 pm
The Role of Mitochondria and Redox Biology in Regulating Inflammation in Human Diseases: From Infection to Metabolism
Chairs: Kimberly Dunham-Snary, PhD, Queen’s University, Canada and Stephen Archer, MD, Queen’s University, Canada

Mitochondria and immunity are inextricably linked, beginning with the mitochondria’s intriguing evolutionary origin story as an ancient alpha-proteobacterium. Mitochondria, and its regulation of metabolism, are key regulators of immune cell activation, differentiation, and survival. Mitochondria regulate metabolism and immune cell activation through a complex cascade, and release signalling mediators which activate immune processes. Mitochondria are intriguingly both a target for some, and a defence against other pathogens, and inflammation in the absence of infection is critical to many chronic diseases, including cardiometabolic syndrome. This session will highlight the latest insights into the role of mitochondrial and redox biology in immunology, focusing on novel findings in host response to bacterial and viral infections, crosstalk between mitochondria and the inflammasome, and our increasing knowledge of the role of the immune system in chronic metabolic diseases.

9:30 am - 10:00 am   
Mitochondrial DNA and Vascular Dysfunction in Diabetes and Hypertension
Rita Tostes, M.Sc, PhD, University of Sao Paulo, Brazil

10:00 am - 10:30 am
Neutrophil Mitochondria Mediate Killing of Staphylococcus Aureus ex vivo
Kimberly Dunham-Snary, PhD, Queen’s University, Canada

10:30 am - 11:00 am
Break

11:00 am - 11:30 am
The Role of Inflammation in Chronic Metabolic Diseases
Norbert Leitinger, PhD, University of Virginia, USA

11:30 am - 12:00 pm 
SARS-CoV-2 Mitochondriopathy in COVID-19 Pneumonia Exacerbates Hypoxemia
Stephen Archer, MD, Queen’s University, Canada

PLENARY SESSION 2
9:30 am - 12:00 pm
Mitochondrial Metabolites and Tissue Health and Disease
Chairs: Philip Eaton, PhD, Queen Mary University of London, UK and Mariana Fernandez-Caggiano, PhD, Queen Mary University of London, UK

Mitochondrial TCA cycle metabolites, such as succinate, fumarate and itaconate, have recently emerged as major players in many disease areas. Some of the underlying mechanisms open whole new avenues for treatment of many diseases, such as heart attack, heart failure, stroke, inflammation, and cancer.

9:30 am - 10:00 am
Roles of Mitochondrial NAD Redox and Metabolism in Cardiac Dysfunction
Chi Fung Lee, PhD, Oklahoma Medical Research Foundation, USA

10:00 am - 10:30 am
Succinate in the Regulation of Ischemia and Reperfusion Injury
Thomas Krieg, PhD, University of Cambridge, UK

10:30 am - 11:00 am
Break

11:00 am - 11:30 am 
Unifying Mechanisms of Metabolic Signalling
Edward Chouchani, PhD, Harvard Medical School, Dana-Farber Cancer Inst., USA

11:30 am - 12:00 pm             
Heart Failure - Emerging Roles for the Mitochondrial Pyruvate Carrier
Mariana Fernandez-Caggiano, PhD, Queen Mary University of London, UK

12:00 pm - 12:30 pm
SfRBM Year in Review: Annual Member Meeting

12:30 pm - 2:30 pm
Lunch
Attendees on own

12:45 pm - 1:45 pm
Baker Ruskinn Presents: Unlocking the Potential of the Mammalian Electron Transport Chain
Dr. Jessica Spinelli, UMass Chan Medical
Sponsored by Baker Ruskinn
Lunch will be provided to all session attendees

Baker Ruskinn is a world leader in "Physoxic" Cell culture, offering equipment to regulate and monitor oxygen in cell culture environments. Here, we will present our companies' visions for mimicked in vivo cell culture solutions and the advantages of cell culture using Continuous Physiological Oxygen. Our collaborator Dr. Spinelli will discuss her exciting new research using these controlled environments on the mitochondrial electron transport chain (ETC). The ETC is a series of electron transfer reactions that support bioenergetic, biosynthetic, and signaling pathways. Here, she will elucidate novel mechanisms of plasticity within the mammalian electron transport chain and start to unravel the reasons for tissue-specificity of these pathways.

1:00 pm - 2:15 pm
Professional Development Session 1: Advancing Your Career & Networking for Early-Career Scientists
David Heppner, PhD, The University at Buffalo, SUNY, USA

1:00 pm - 2:15 pm
Professional Development Session 2: Becoming a Confident and Resilient Scientist
Adam Case, PhD, Texas A&M University, USA

2:30 pm - 4:15 pm
Oral Presentations from Submitted Abstracts
3 concurrent sessions

4:15 pm - 6:45 pm
Formal Poster Presentations

7:00 pm - 7:30 pm
FRBM Editorial Board Meeting

7:30 pm - 8:00 pm
Redox Biology Editorial Board Meeting

8:00 pm - 9:00 pm
FRBM and Redox Biology Editors & Editorial Board Members Joint Reception

9:00 pm - 11:00 pm
Hospitality

FRIDAY, NOVEMBER 18, 2022

7:00 am - 6:30 pm
Registration/Information Desk

SUNRISE FREE RADICAL SCHOOL
8:00 am - 9:00 am
Back to Basics
Chairs: Kimberly Dunham-Snary, PhD, Queen’s University, Canada and Adam Case, PhD, Texas A&M University, USA

8:00 am - 8:30 am
Fundamentals of Xanthine Oxidoreductase: Oxidants, Uric Acid and Nitric Oxide
Eric Kelley, PhD, West Virginia University, USA

8:30 am - 9:00 am
Lipid Oxides and Their Regulation
M. Ryan Smith, PhD, Emory University, USA

PLENARY SESSION 3
9:30 am - 12:00 pm
Membrane Redox State: A Matter of Life and Death
Chairs: Sayuri Miyamoto, PhD, University of Sao Paulo, Brazil and Ginger Milne, PhD, Vanderbilt University Medical Center, USA

The membrane redox state is primarily dictated by the oxidation state of unsaturated lipid components. The fine balance of the membrane redox state requires the coordinated action of oxidant and antioxidant systems. This symposium will highlight recent advances in the newly discovered roles of sterols in membrane redox state and cell death mechanisms, together with discussions on lipid remodeling, homeostasis and the state-of-the-art tools needed to explore and navigate the complex and dynamic changes occurring during signalling and cell death.

9:30 am - 10:00 am
Shielding of Phospholipid Oxidation by 5,7-unsaturated Sterol Metabolites
José Pedro Friedmann Angel, PhD, University of Würzburg, Germany

10:00 am - 10:30 am 
7-Dehydrocholesterol, Nature's Most Vulnerable Membrane Lipid: Oxidation, Oxysterols and Electrophiles
Ned Porter, PhD, Vanderbilt University, USA

10:30 am - 11:00 am
Break

11:00 am - 11:30 am
Epilipidome and Lipid Quality Control of Membranes
Rajiv Ratan, MD, PhD, Burke Neurological Institute, Weill Cornell Medicine, USA

11:30 am - 12:00 pm 
Mechanisms of Lipid Homeostasis and Ferroptosis Suppression
James Olzman, PhD, University of California - Berkeley, USA

PLENARY SESSION 4 
9:30 am - 12:00 pm
Uric Acid in the Etiology of Metabolic Syndrome and Cardiovascular Disease
Chair: Eric Kelley, PhD, University of West Virginia, USA and Nicholas Khoo, PhD, University of Pittsburgh, USA

Recognized as the terminal product of purine degradation in primates, uric acid has historically been proposed to function as an antioxidant and thus, in part, to replace our evolutionary loss of capacity to synthesize ascorbate. Therefore, when present at normal physiologic levels, uric acid is proposed to be a scavenger of singlet oxygen, peroxynitrite and lipid-derived radicals whereas elevation in uric acid concentration induces urate crystal formation resulting in gout. This paradigm for the role of uric acid in normal and pathophysiology has recently been highlighted as numerous reports indicate that elevated circulating uric acid levels correlate with poor cardiovascular outcomes as well as obesity. This body of work has also begun to elucidate potential mechanisms for uric acid-mediated proinflammatory signaling that drive the pathophysiology of obesity and allied co-morbidities, such as metabolic syndrome and diabetes. For example, increased levels of circulating uric acid have been associated with hyperlipidemia, insulin resistance, NASH/NAFLD, endothelial dysfunction, hypertension and stroke. This has been reported to be mediated by high fructose intake which, in turn, results in elevated uric acid levels. However, alteration of uric acid at the level of production (xanthine oxidoreductase) and catabolism (urate oxidase) is inextricably linked to oxidant generation as oxygen is the terminal electron acceptor for both enzymes. This is crucial as both uric acid and ROS have been proposed to be seminal mediators of the pathophysiology associated with the co-morbidities common to obesity. Efforts to assign contributions specific to uric acid including diminution of circulating uric acid levels by modulating clearance via the kidney with uricosurics (benzbromarone or probenecid) have met with mixed results affirming the need for carefully designed studies that consider these issues. As such, this session is designed to establish the current state of the field and highlight the latest advancements regarding mechanistic details of the impact of elevated uric acid on metabolic and vascular dysfunction ranging from metabolic syndrome to hypertension.

9:30 am - 10:00 am
Uric Acid and the Etiology of Diabetes, Obesity and Chronic Kidney Disease: Where Are We Now?
Richard Johnson, MD, University of Colorado Denver Health Sciences, USA

10:00 am - 10:30 am
The Impact of Fructose, Urate and Hydration on Renal Function and Hypertension
Laura Gabriela Sánchez-Lozada, PhD, Instituto Nacional de Cardiología, Mexico

10:30 am - 11:00 am
Break

11:00 am - 11:30 am
Uric Acid, Xanthine Oxidase Inhibition and Risk of Stroke
Jesse Dawson, MD, University of Glasgow, UK

11:30 am - 12:00 pm
The Role of the XDH Expression in Gout Risk and the Prostate in Circulating Uric Acid Concentration
Megan Leask, PhD, University of Alabama at Birmingham, USA

12:00 pm - 12:30 pm     
SfRBM Lifetime Achievement Award Lecture
From O2 to NO meeting CO2

Ohara Augusto, PhD, University of São Paulo, Brazil

12:30 pm - 2:30 pm
Lunch 
Attendees on own

12:45 pm - 1:45 pm
Lunch n' Learn - Sponsored by Noxygen
Cellular Metabolic Activity as Diagnostic Tool for Cardiovascular & Inflammatory Implications
Bruno Fink, MD., CEO, Scientific Advisor, Noxygen Science Transfer & Diagnostic GmbH
Sergey Dikalov, Ph.D., Director of Free Radicals in Medicine Core, Vanderbilt University Medical Center


This session will provide attendees an opportunity to understand how to apply EPR methodology in clinical and basic research-oriented studies targeting cardiovascular  and inflammatory implications. Learn how to use Cellular Metabolic Activity (CMA) assays to investigate the nature of reactive oxygen species in pleiotropic physiological signaling using  Noxygen’s new portable EPR spectrometer “VitaScreen”. Speakers will discuss the results of recent studies in segments covering: 

  • Clinical and animal EPR study of superoxide in whole blood, immune cells and vascular tissue: Implications for hyper-oxygenation and inflammation
  • Diagnostic and differential diagnostic value of cellular metabolic activity assays to understand the vascular, cardiotoxic, and Covid-19 implications

Lunch will be provided to all session attendees

1:00 pm - 2:15 pm
Professional Development Session 3: DEIR in our Research Group. Are we there yet?
Karina Ckless, PhD, SUNY Plattsburgh, USA

1:00 pm - 2:15 pm
Professional Development Session 4: Team Motivation and Engagement: From Undergraduate Students to Junior Scientists
Peter Vitiello, PhD, University of Oklahoma Health Sciences Center, USA

2:30 pm - 4:15 pm
Oral Presentations from Submitted Abstracts
3 concurrent sessions

4:15 pm - 6:45 pm
Formal Poster Presentations

6:45 pm - 9:00 pm
Opening Doors Event: Six Degrees of Separation: The Key to Networking in the Redox Community
Francisco Laurindo, MD, F-SFRBM, Heart Institute (INCOR), University of São Paulo School of Medicine, Brazil, Reto Asmis, PhD, F-SFRBM, Wake Forest School of Medicine, USA, Giovanni Mann, PhD, King's College London, UK, Yvonne Janssen-Heininger, PhD, F-SFRBM, University of Vermont, USA

9:00 pm - 11:00 pm
Hospitality

SATURDAY, NOVEMBER 19, 2022

7:00 am - 6:30 pm
Registration/Information Desk

SUNRISE FREE RADICAL SCHOOL 
8:00 am - 9:00 am
Back to Basics
Chairs: Kimberly Dunham-Snary, PhD, Queen’s University, Canada and Adam Case, PhD, Texas A&M University, USA

8:00 am - 8:30 am
The Relationship Between Radiation and Redox Biology
Michael Hitchler, PhD, Kaiser Permanente Los Angeles Medical Center, USA

8:30 am - 9:00 am
Small Molecule Antioxidants: Uses, Pros, and Cons
Debra Boyd-Kimball, PhD, University of Mount Union, USA

PLENARY SESSION 5
9:30 am - 12:00 pm
Targeting Redox Metabolism in Cancer Treatment Resistance: From Chemistry and Biology to the Clinic
Chairs: Michael Graham Espey, PhD, National Cancer Institute, USA and Rebecca Oberley-Deegan, PhD, University of Nebraska Medical Center, USA

This session will examine the interdisciplinary crossroads between Redox Biology and Radiation Oncology consistent with the theme of understanding how chemistry and biological mechanistic approaches inform and impact clinical practice.  Cancer metabolic reprograming enables plasticity and robustness towards therapy resistance; however, insight into the fundamental redox underpinnings of these processes can identify vulnerabilities that have potential to be targeted through novel radiation-drug combinations.  Attendees will gain an integrative understanding of the both challenges and opportunities in redox biology and cancer treatment. 

9:30 am - 10:00 am
Stem Cells, Metabolism, and Therapeutic Resistance in Glioblastomas
Jennifer Yu, MD, PhD, Case Comprehensive Cancer Center; Center for Stem Cell Research, Cleveland Clinic, USA

10:00 am - 10:30 am
Redox Metabolism in the Context of Radiation Damage in Fibroblast and Adipocytes
Rebecca Oberley-Deegan, PhD, University of Nebraska Medical Center, USA

10:30 am - 11:00 am
Break

11:00 am - 11:30 am
Sensitization of Resistant Prostate Cancers to Radiation Through Mitochondrial Translation Targeting Coupled With Overloading Mitochondrial ROS
Luksana Chaiswing, PhD, University of Kentucky, USA

11:30 am - 12:00 pm
Radiation-induced Pancreatic Cancer Cell Killing by Simultaneous Inhibition of NF-kB and Warburg Metabolism
Marc S. Mendonca, PhD, IUPUI & Indiana University School of Medicine, USA

12:00 pm - 12:30 pm
New Member Welcome Meeting

12:00 pm - 2:30 pm
Lunch
Attendees on own

2:30 pm - 4:15 pm
Oral Presentations from Submitted Abstracts
3 concurrent sessions

4:15 pm - 6:45 pm
Formal Poster Presentations

7:30 pm - 9:30 pm
Closing Awards Banquet

9:30 pm - 11:00 pm
Hospitality

SfRBM 2022 officially adjourns after the Closing Awards Banquet on Saturday, November 19.