Free Radical School Virtual Seminar Series

SFRBM offers these virtual sessions on a quarterly basis, providing valuable education on a wide range of topics. The sessions are open to SFRBM members only and are offered at no charge.

Vitamin E Actions and Regulations
Wednesday, May 8, 2013
Speaker: Maret Traber, Ph.D.
Linus Pauling Institute
Length of session: 60 minutes
1:00 pm Eastern (12:00 pm Central, 11:00 am Mountain, 10:00 am Pacific; this is 17:00 GMT/UTC)
International attendees should convert the time accordingly.



PROGRAM OVERVIEW:

A growing body of evidence suggests that not only free radical-mediated reactions, but also inflammatory responses, play major roles in chronic diseases such as heart disease, diabetes, metabolic syndrome and neurodegenerative diseases. Vitamin E has both antioxidant and anti-inflammatory properties and, therefore, is the most widely studied vitamin in intervention trials with nutrient supplements. Meta-analyses of these trials have suggested that vitamin E supplements cause adverse consequences, notably increased mortality, but the mechanisms for such consequences are largely unknown.

Dr. Traber’s lab at Linus Pauling Institute has been studying the question “What are the regulatory mechanisms that control vitamin E status?”. The liver is at the intersection of the regulation of lipoprotein uptake, synthesis, and secretion; and the site of xenobiotic detoxification by cytochrome P450 oxidation systems (phase I), conjugation systems (phase II) and transporters (phase III). These two major liver systems are essential for the control vitamin E status.

The mechanisms for the body’s preference for α-tocopherol relative to the eight dietary vitamin E forms are largely dependent upon the liver. These mechanisms include both the preferential secretion of α-tocopherol from the liver (mediated by the α-tocopherol transfer protein) into the plasma for the transport of α-tocopherol in circulating lipoproteins for subsequent uptake by tissues, as well as the preferential hepatic metabolism and excretion of non-α-tocopherol forms. These mechanisms are the focus of this webinar.

PROGRAM FORMAT:
Members can attend a SFRBM Virtual Free Radical School session right from your office or home. All you need to participate is a telephone and a computer with high speed internet connection. The audio is delivered over the telephone (toll-free). Registrants will be provided call in/login information 2-3 days prior to the session and a URL to access the presentation right on the web in real time.

COST:
There is no cost for SFRBM members to participate. The webinar is open to SFRBM members only.

ABOUT THE SPEAKER:
Dr. Maret Traber is Helen P. Rumbel Professor for Micronutrient Research in the Linus Pauling Institute (LPI) at Oregon State University, Corvallis, Oregon, USA. With more than 250 scientific publications, Dr. Traber is considered one of the world’s leading experts on vitamin E.  Her research efforts are focused on human vitamin E kinetics and the factors that modulate human vitamin E requirements, especially bioavailability and metabolism.  She currently serves on the editorial boards of Free Radical Biology & Medicine and of Redox Biology. In 2000, Dr. Traber served on the National Academy of Science’s, Institute of Medicine Panel on Dietary Antioxidants and Related Compounds that established the dietary requirements for the antioxidant vitamins C and E, selenium and carotenoids.

 

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