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Mouse brain plasmalogens are targets for hypochlorous acid-mediated modification in vitro and in vivo

Publication year: 2010
Source: Free Radical Biology and Medicine, In Press, Accepted Manuscript, Available online 31 August 2010

Andreas, Üllen , Günter, Fauler , Harald, Köfeler , Sabine, Waltl , Christoph, Nusshold , ...

Plasmalogens, 1-O-alk-1?-enyl-2-acyl-sn-glycerophospholipids are significant constituents of cellular membranes and are essential for normal brain development. Plasmalogens, which contain a vinyl ether bond at the sn-1 position, are preferential targets for hypochlorous acid (HOCl), generated by myeloperoxidase (MPO) from H2O2 and chloride ions. Since MPO is implicated in neurodegeneration, the present study pursued two aims: i) to investigate the reactivity of mouse brain plasmalogens towards HOCl in vitro, and ii) to obtain in vivo evidence for MPO-mediated brain plasmalogen modification. Liquid chromatography coupled to hybrid linear ion trap - Fourier transform - ion cyclotron resonance mass spectrometry revealed plasmalogen modification in...


Thu, 02 Sep 2010 12:09

An oxidative environment promotes growth of Mycobacterium abscessus

Publication year: 2010
Source: Free Radical Biology and Medicine, In Press, Accepted Manuscript, Available online 31 August 2010

Rebecca E., Oberley-deegan , Brittany W., Rebits , Michael R., Weaver , Angela K., Tollefson , Xiyuan, Bai , ...

Mycobacterium abscessus (M. abscessus) infections, particularly those causing chronic lung diseases, are becoming more prevalent worldwide. M. abscessus infections are difficult to treat due to antibiotic resistance. Thus, new treatment options are urgently needed. M. abscessus are intracellular pathogens that primarily infect macrophages and fibroblasts. Because this bacterium has only recently been identified as a separate species, very little is known about M. abscessus-host interactions and how M. abscessus growth is regulated. Oxidative stress has long been shown to inhibit growth of bacterial organisms. However, some intracellular bacteria, such as Mycobacterium tuberculosis, grow well in oxidizing environments. In the present...


Thu, 02 Sep 2010 12:09

Editorial Board

Publication year: 2010
Source: Free Radical Biology and Medicine, Volume 49, Issue 7, 15 October 2010, Page IFC

[No author name available]


Fri, 27 Aug 2010 03:08

Invitation to Submit Critical Methods Articles

Publication year: 2010
Source: Free Radical Biology and Medicine, Volume 49, Issue 7, 15 October 2010, Page v

[No author name available]


Fri, 27 Aug 2010 03:08

Announcements and Calendar

Publication year: 2010
Source: Free Radical Biology and Medicine, Volume 49, Issue 7, 15 October 2010, Page 1254

[No author name available]


Fri, 27 Aug 2010 03:08