Free Radical School Virtual Seminar Series

SfRBM offers these virtual sessions on a quarterly basis, providing valuable education on a wide range of topics. The sessions are open to SfRBM members only and are offered at no charge.

Protein Kinase A and G as Redox Targets:
Molecular Mechanisms and Physiological Consequences


Date: Wednesday, April 11, 2018
Speaker: Philip Eaton, Ph.D. - King's College London
Length of session: 60 minutes
Time: 1:00 pm Eastern (12:00 pm Central, 11:00 am Mountain, 10:00 am Pacific; this is 17:00 GMT/UTC);
International attendees should convert the time accordingly.
The deadline to register was Friday, April 6, 2018.

PROGRAM OVERVIEW

This session will explain how thiol redox proteomics studies lead to the identification of PKA and then PKG as a target of oxidants and will explain what we currently know about the regulation of these kinases by oxidation. This session will also highlight what Dr. Eaton has found using ‘redox-dead’ transgenic mice that have been genetically altered so each kinase is individually resistant to oxidation, focusing on the consequences for the cardiovascular system. Dr. Eaton's work on PKG is consistent with the oxidation of this kinase being important for blood pressure lowering, as well as relaxation of the heart during diastole. Thus, Dr. Eaton's team screened and identified drugs that couple to PKG oxidation, and he will outline their potential as a novel therapy for hypertension and diastolic heart failure.

ABOUT THE SPEAKER

Philip Eaton gained a BSc in Biochemistry from Queen Mary College, University of London in 1989 before completing his PhD studies at the University of Sussex. He joined the Department of Cardiovascular Research, at the Rayne Institute, St Thomas’ Hospital in 1995. He remains at the same location within the School of Cardiovascular Medicine and Sciences and British Heart Foundation Centre of Research Excellence at King’s College London where he is Professor of Cardiovascular Biochemistry. A major focus of his work is the molecular basis of redox signalling in the cardiovascular system. By identifying redox sensor proteins susceptible to oxidant-dependent alterations in structure and function, it is hoped we can better understand the biological significance of these modifications during cardiovascular health and disease.

PROGRAM FORMAT

Members can attend an SFRBM Virtual Free Radical School session right from your office or home. All you need to participate is a telephone and a computer with high-speed internet connection. The audio is delivered over the telephone (toll-free). Registrants will be provided call in/login information 2-3 days prior to the session and a URL to access the presentation right on the web in real time.

 
 

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