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funding for research and low morale, what is the best advice?

There is always room for optimism, and recent reports are that NIH 

may get a long-needed boost in support from Congress. Newt Gingrich 

recently wrote an Op-Ed in the New York Times (Apr 21, 2015) calling 

for another doubling of the NIH budget, and in mid-May, the U.S. House 

of Representatives released a draft bill that aims to increase the NIH 

budget by $10 billion over 5 years. These shifting winds mean that 

investigators should stay tuned for additional evolving opportunities. 

Your Society leadership is trying to bring awareness to the ield of 

redox biology and medicine at the NIH and other federal granting 

agencies by bringing scientiic review administrators and program 

oficers to the annual meetings to hold workshops for our members 

and highlight recent trends and funding opportunities in our ield.

DOT: Being a mentor, you have shaped many students (graduate and 

postdoc) to enter academic and industry research, any tips how to 

shape individuals for these scientiic ields?
Past members of Domann’s Lab who started with SFRBM as student members and have transitioned into 

their academic and industry research.
There is no substitute for assiduity and a solid work ethic; being present (From L to R) Kimberly Krager, Michael Hitchler, Rick Domann, Adam Case, Trent Place, and Collin Heer

is the greatest part of success. Beyond that, astute observational and 
there is inally a realization in the community that redox sensors have 
critical thinking skills are required in a scientiic profession of any kind. In 
been frequently misconstrued as antioxidant defenses when in many 
addition, organizational, time management, and effective interpersonal 
cases they are in fact signal transducing modules. All major disease of 

communication are all key elements to success in science. I believe 
mankind possess an oxidative stress component to their pathologies, 
that proposals and reports need be compiled in a technically accurate 
and so in order to cure these disease a deeper understanding of the 
manner and written in cogent prose in both academic and industry 
redox signaling relays evolved in life in oxygen is needed.
roles, so I think at least at the graduate training level there is little 

difference in how I would prepare them. At the post-doctoral level, a DOT: And in the other direction, translational research.

postdoc interested in industry may test the waters irst by doing an 
Translational research utilizing basic knowledge learned from redox 
industry post-doc or internship.
biology is growing exponentially. The role of free radicals and redox 

DOT: What do you think is the direction the Oxidative Stress ield is biology in inlammation, cancer, diabetes, cardiovascular and pulmonary 

diseases is well appreciated. Now, pharmacological control of certain 
of these systems is well in hand and drugs that mimic SOD activity are 

Interesting question. I think that life is stress, especially life in an 
in clinical trials. Also, the paradoxical pro-oxidant effects of high dose 
oxygen rich world. Thus all living organisms are in a non-steady state 
vitamin C are making a big comeback in cancer clinics nationally with 
equilibrium that oscillates around various levels depending upon 
promising results using high C as an adjuvant for traditional therapies 
physical, biological, and environmental cues. A normal state of existence 
with no notable toxicity. Also, the role of redox couples that sense and 
might be thought of as “eustress”, which is a normal and good part of 
signal oxidative stress, such as NADH/NAD+ are found to be vitally 
life that is hormetic and that allows for rapid adaptive responses in 
important for aging and cancer by altering the activity of sirtuin family 
either direction to maintain cell and tissue redox balance. Additionally,
enzymes, and oral nicotinamide was recently found to provide signiicant

SFRBM Newsletter // July 2015 // Radical View • Dr. Rick Domann

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