Conference Program

Daily Schedules

Wednesday
  Pre-Conference Workshop
  Opening Session
Thursday
Friday
Saturday

WEDNESDAY, NOVEMBER 18, 2020

7:00 am - 6:30 pm
Registration/Information Desk

PRE-CONFERENCE WORKSHOP*
Redoxomics in the 21st Century: From Chemistry to Chromatin
Chairs: Kimberly Dunham-Snary, PhD, Queen's University, Matthew Ryan Smith, PhD, Emory University, and Fredrick Domann, PhD, F-SfRBM, University of Iowa
*Additional cost - requires registration

Advances in the field of systems biology have led to the generation and analysis of large datasets allowing numerous novel discoveries in human physiology and the pathogenesis of disease. The application of ‘omics technologies have provided better understanding of the complexity in cellular signalling networks and opened a new avenue of investigation in the field of redox biology. An example of this is the field of epigenomics – the regulation of the activities of DNA and histone-modifying enzymes. Discoveries over the last decade have revealed that epigenetic control mechanisms are targets of redox regulation and mitochondrial-to-nuclear retrograde signaling. It is now understood that demethylation of DNA and histones is accomplished by families of enzymes, both writers and erasers, that are subject to several levels of redox and metabolic control including by the bioavailability of oxygen, nutrients, and metabolite co-factors necessary for optimal enzyme activity. Other ‘omics’ platforms have been widely applied in the fields of cardiovascular disease, cancer, and stem cell research, but there remains tremendous potential in the field of redox biology. Integrating these various platforms is the critical next step to elucidate the cellular mechanisms of redox signaling and to understand the true complexity of human physiology. This session will assemble numerous leading experts in the fields of epigenomics, metabolomics, lipidomics, redox biology and systems biology to: i) provide insights into the integration of our current understanding of redox biology with these state-of-the-art tools, ii) challenge our understanding of how remarkable cellular networks truly interact, and iii) provide the framework for potential new discoveries of the Redox-ome.

9:00 am - 9:05 am
Welcome / Part I Overview

9:05 am - 9:30 am
'Ome is Where the Heart is 
Charles Hindmarch, PhD, Queen's University, Queen's Cardiopulmonary Unit, & Translational Institute of Medicine, Canada

9:30 am - 9:55 am 
Oxylipidomics and Redox-Systems Biology in Blood-Clotting
Valerie O'Donnell, PhD, Cardiff University, UK

9:55 am - 10:20 am
BREAK

10:20 am - 10:45 am
Redox Metals at the Interface of the Metabolome, Exposome and Genome
Dean Jones, PhD, Emory University, USA

10:45 am - 11:10 am
Epitranscriptomic Regulation of Selenoprotein Translation and Consequences for ROS Detoxification
Thomas Begley, PhD, University of Albany SUNY, USA

11:10 am - 11:35 am
Novel Technologies for Cardiovascular Biomarker Discovery
Robert Gerszten, MD, Beth Israel Deaconess Med. Ctr., Harvard Medical School & The Broad Institute, USA

11:35 am - 1:00 pm
Lunch

1:00 pm - 1:05 pm
Welcome / Part II Overview

1:05 pm - 1:30 pm
Epigenetics, the Third Pillar of Nitric Oxide Signaling
Douglas Thomas, PhD, University of Illinios at Chicago, USA

1:30 pm - 1:55 pm    
Dynamic Regulation of Epigenetic Demethylation by Oxygen Availabilty 
Alison Brewer, PhD, King's College London, UK

1:55 pm - 2:20 pm
BREAK

2:20 pm - 2:45 pm
cAMP Signaling and Labile Fe(II) in Epigenomic Regulation
Gaofeng Wang, PhD, University of Miami, USA

2:45 pm - 3:10 pm
Mitochondrial Control of Nuclear Epigenetic Reprogramming
Janine Santos, PhD, National Institutes of Health, USA

3:10 pm - 3:35 pm
Inhibition of DNA Methylation in Proliferating Human Lymphoma Cells by Immune Cell Oxidants
Mark Hampton, PhD, University of Otago, Christchurch, New Zealand

3:35 pm - 3:45 pm
Closing Remarks
 


ANNUAL CONFERENCE BEGINS

5:00 pm - 5:10 pm
SfRBM President's Welcome
Phyllis Dennery, MD, Brown University / Rhode Island Hospital, USA - SfRBM President 

PRESIDENTIAL PLENARY SESSION
5:00 pm - 7:10 pm
TBD

5:10 pm - 5:40 pm
TBD

5:40 pm - 6:10 pm     
TBD

6:10 pm - 6:40 pm     
TBD

6:40 pm - 7:10 pm
TBD

7:15 pm - 9:00 pm
Welcome Reception

7:15 pm - 8:30 pm
Trainee Welcome Event

THURSDAY, NOVEMBER 19, 2020

7:00 am - 6:30 pm
Registration/Information Desk

SUNRISE FREE RADICAL SCHOOL
8:00 am - 9:00 am
Back to the Basics
Chairs: Kimberly Dunham-Snary, Ph.D., Queen's University, Canada and Carola Neumann, MD, University of Pittsburgh, USA

8:00 am - 8:30 am
Yin and Yang of Immune Function in Developmental Programming
Rebecca Simmons, MD, Pennsylvania School of Medicine, USA

8:30 am - 9:00 am
The Yins and Yangs of Sirtuins in Malignancy
David B. Lombard, MD, PhD, University of Michigan, USA

PLENARY SESSION 1
9:30 am - 12:00 pm
Where We Begin Matters: Influence of Oxidative Stress in the Developmental Origins of Adult Disease
Chairs: Peter Vitiello, PhD, University of Oklahoma, USA and Lin Mantell, MD, PhD, St. John's University College of Pharmacy/Northwell Health System, USA

Though the concept of developmental origins of health and disease is not new, redox perturbations during fetal and perinatal development are increasingly recognized as a key factor for numerous adult diseases. This session will discuss mechanisms by which early life exposure to oxidative stress affects development and adult disease through dysfunctional redox signaling, metabolic reprogramming, and epigenetic modifications.

9:30 am - 10:00 am   
Unique Age-Dependent Redox-Responses to Oxidant Lung Injury
Eva Nozik-Grayck, MD, University of Colorado Anschutz Medical Center, USA

10:00 am - 10:30 am
Neonatal Hyperoxia Causes Adult Disease by Reprogramming Cellular Metabolism
Michael A. O'Reilly, PhD, The University of Rochester Medical Center, USA

10:30 am - 11:00 am
BREAK

11:00 am - 11:30 am
Understanding Aging Through the Prism of Alveolar Macrophages - How Mitochondria Matter
G.R. Scott Budinger, MD, Northwestern University, USA

11:30 am - 12:00 pm 
Redox Mechanism for the Beneficial Effect of Maternal Exercise to Improve Offspring Metabolic Health
Laurie Goodyear, PhD, Harvard Medical School, USA

PLENARY SESSION 2
9:30 am - 12:00 pm
The Janus Face of Sirtuins in Health and Cancer
Chairs: Nadine Hempel, PhD, Penn State University College of Medicine and Doris Germain, PhD, Mount Sinai Icahn School of Medicine

The acetylome has emerged as a major point of integration between metabolism, redox homeostasis and cellular reprogramming in health and disease. Novel research highlighted in this session demonstrates that Sirtuin (SIRT) deacetylases, the acetylation state of some sirtuin target proteins and the subsequent changes in oxidants and metabolism are intimately connected with cancer progression. It has come to light that the role of sirtuin enzymes is often context dependent and that this dictates their dichotomous function in cancer initiation and metastatic progression. Our plenary talks highlight this Janus face of sirtuins, focusing on their regulation and role during tumorigenesis, metastasis, stem cell reprogramming and the development of chemotherapy resistance.

9:30 am - 10:00 am
Sirtuins Connect Longevity, Health and Cancer Via Regulating of the Mitochondrial Acetylome
David Gius, MD, PhD, Northwestern University, Chicago, IL

10:00 am - 10:30 am
The SIRT3 Axis of the Mitochondrial UPR Up-Regulates SOD2 and Promotes Metastasis
Doris Germain, PhD, Mount Sinai Icahn School of Medicine, New York, NY

10:30 am - 11:00 am
BREAK

11:00 am - 11:30 am 
TBD
Marcia Haigis, PhD, Harvard Medical School, USA

11:30 am - 12:00 pm             
Transient Changes in SIRT3 and SOD2 Drive Anchorage Independent Survival and Ovarian Cancer Metastasis
Nadine Hempel, Pennsylvania State University, Hershey, PA

12:00 pm - 12:30 pm
SfRBM Year in Review: Annual Member Meeting

12:30 pm - 2:30 pm
Lunch
Attendees on own

1:00 pm - 2:15 pm
Professional Development Session 1: The Art of the Interview Chalk Talk
Adam Case, PhD, University of Nebraska Medical Center, USA, Damian Guerra, PhD, University of Louisville, USA, and Samantha Giordano-Mooga, PhD, University of Alabama at Birmingham, USA

1:00 pm - 2:15 pm
Professional Development Session 2Speed Mentoring
Rajasekaran Namakkal Soorappan, M.Phil., PhD, University of Alabama at Birmingham, USA and Ben Boivin, PhD, SUNY Polytechnic Institute, USA

2:30 pm - 4:15 pm
Oral Presentations from Submitted Abstracts
3 concurrent sessions

4:15 pm - 6:45 pm
Formal Poster Presentations

6:45 pm - 9:00 pm
Opening Doors Event: Leading by Example: Fostering Safe and Inclusive Research and Training Environments
Yvette Seger, PhD, Office of Public Affairs/FASEB and Hannah A. Valantine, MD, NIH Scientific Workforce Diversity

Yvette Seger, PhD, is the Deputy Director of the Office of Public Affairs and Director of Science Policy for the Federation of American Societies for Experimental Biology (FASEB), a coalition of 28 scientific societies collectively representing over 130,000 individual biological and biomedical researchers. In these roles, she contributes to the overall strategic vision for the Office of Public Affairs, specifically guiding the efforts of FASEB’s Science Policy Committee and the work of its topical working groups. Dr. Seger is actively engaged in FASEB’s efforts pertaining to Diversity, Equity, and Inclusion (DEI), playing a key role in the development of FASEB’s DEI Strategic Plan and guiding the efforts of its DEI Committee. Dr. Seger serves on the Leadership Council of the Societies Consortium for Sexual Harassment in STEMM, helping foster discussion and development of resources to aid societies in their efforts in serving as standard-bearers in addressing sexual harassment in their respective fields. She holds a PhD in Genetics from Stony Brook University and received a BA in Zoology (Genetics Concentration) and Politics & Government from Ohio Wesleyan University.

7:00 pm - 7:30 pm
FRBM Editorial Board Meeting

7:30 pm - 8:00 pm
Redox Biology Editorial Board Meeting

8:00 pm - 9:00 pm
FRBM and Redox Biology Editors & Editorial Board Members Joint Reception

9:00 pm - 11:00 pm
Hospitality

FRIDAY, NOVEMBER 20, 2020

7:00 am - 6:30 pm
Registration/Information Desk

SUNRISE FREE RADICAL SCHOOL
8:00 am - 9:00 am
Back to the Basics
Chairs: Kimberly Dunham-Snary, Ph.D., Queen's University, Canada and Carola Neumann, MD, University of Pittsburgh, USA

8:00 am - 8:30 am
Cellular Microdomains for Redox Signaling in the Vasculature
Brant Isakson, PhD, University of Virginia School of Medicine, USA

8:30 am - 9:00 am
Peroxynitrite and Tyrosine Nitration: Biochemistry and Biological Consequences
Ana Denicola, PhD, Universidad de la República - Uruguay

PLENARY SESSION 3
9:30 am - 12:00 pm
Cellular Microdomains for Redox Signaling in the Vasculature
Chairs: Brant E. Isakson, PhD, University of Virginia, USA and Miriam M. Cortese-Krott, PhD, University of Düsseldorf, Germany

There is accumulating evidence that biological membranes are highly organized in microdomains. Recent evidence demonstrated that microdomains are crucial for organizing and compartmentalizing redox signals particularly in the vascular system and thereby may contribute to blood pressure control and cardiovascular homeostasis. In this session, we aim to describe how membrane microdomains in both the endothelium and red blood cells allow context-specific regulation of signaling of reactive species, including nitric oxide (and its metabolites) and hydrogen peroxide and how this results in tightly controlled systemic physiological responses.

9:30 am - 10:00 am
TBD
Adam Straub, PhD, University of Pittsburgh, USA

10:00 am - 10:30 am 
TBD
Kathrin Schröder, PhD, University of Frankfurt, Germany

10:30 am - 11:00 am
BREAK

11:00 am - 11:30 am
TBD
Swapnil Sokusare, PhD, University of Virginia, USA

11:30 am - 12:00 pm 
TBD
Miriam M. Cortese-Krott, PhD, University of Düsseldorf, Germany

PLENARY SESSION 4 
9:30 am - 12:00 pm
Peroxynitrite and Tyrosine Nitration: From Biomarker of Oxidative Stress to Signaling Molecule
Chairs: Joe Beckman, PhD, Oregon State University, USA and Maria Clara Franco, PhD, Oregon State University, USA 

Tyrosine nitration is detected in most pathologies associated with inflammation, including cancer and neurodegeneration. The discovery of nitrated proteins that play pathological roles, and reports of cellular denitrase activity, reveal that tyrosine nitration is an oxidative posttranslational modification capable of regulating signaling pathways, posing nitrated proteins as a new category of potential targets for therapeutic development.

9:30 am - 10:00 am
Alternative Conformations and Functions of Cytochrom C: Lessons from Tyrosine Nitration Studies
Rafael Radi, MD, PhD, Universidad de la República, Uruguay

10:00 am - 10:30 am
Apoptotic Signaling Pathways Activated by Peroxynitrite-Mediated Nitration
Alvaro Estevez, PhD, Oregon State University, USA

10:30 am - 11:00 am
BREAK

11:00 am - 11:30 am
Denitrase Activity of the PTPRT Psuedo-Phosphatase Domain
Zhenghe Wang, PhD, Case Western Reserve University, USA

11:30 am - 12:00 pm 
Nitrated Proteins as Tumor-Directed Targets
Maria Clara Franco, PhD, Oregon State University, USA

12:00 pm - 12:30 pm     
SfRBM Lifetime Achievement Award Lecture: TBD
Henrik Poulsen, MD, University of Copenhagen, DK

12:30 pm - 2:30 pm
Lunch 
Attendees on own

12:45 pm - 2:00 pm
Special Luncheon Session - Sponsored by Baker Ruskinn
TBD

TBD

The Baker Ruskinn and Lucid Scientific lunch and learn is an opportunity to understand the benefits of “Physoxic” Cell Culture and the importance of regulating and monitoring oxygen in cell culture environments. During the lunch, we will present our companies’ visions for mimicked in vivo cell culture solutions, the advantages of cell culture using Continuous Physiological Oxygen, and how to measure oxygen consumption in real-time. We will discuss recent project results reflecting true physiological conditions while using the Baker Ruskinn solutions and oxygen conditions using Lucid Scientific’s Resipher. Please join us for a bite to eat and an engaging overview of the dynamics of the cell culture oxygen environment.

Click here to register for this session.
Lunch will be provided to all session attendees.

1:00 pm - 2:15 pm
Professional Development Session 3: TBD
Sophie Maiocchi, PhD, University of North Carolina, Chapel Hill, USA and Trainee Council

1:00 pm - 2:15 pm
Professional Development Session 4: Discussed Negotiations: Negotiation Workshop for Trainees
Carola Neumann, MD, University of Pittsburgh, USA and Peter Vitiello, PhD, Sanford Research, USA

2:30 pm - 4:15 pm
Oral Presentations from Submitted Abstracts
3 concurrent sessions

4:15 pm - 6:45 pm
Formal Poster Presentations

9:00 pm - 11:00 pm
Hospitality

SATURDAY, NOVEMBER 21, 2020

7:00 am - 6:30 pm
Registration/Information Desk

SUNRISE FREE RADICAL SCHOOL 
8:00 am - 9:00 am
Back to the Basics
Chairs: Kimberly Dunham-Snary, Ph.D., Queen's University, Canada and Carola Neumann, MD, University of Pittsburgh, USA

8:00 am - 8:30 am
Title: TBD
Andrea Haase, PhD, German Federal Institute for Risk Assessment (BfR), Germany

8:30 am - 9:00 am
TBD
Dr. Seabra

PLENARY SESSION 5
9:30 am - 12:00 pm
Redox Activity of Engineered Nanomaterials: Safety and Biomedical Application
Chairs: Karina Ckless, PhD, SUNY Plattsburgh, USA and Darlene Taylor, PhD, North Carolina Central University, USA

The development of new engineered nanomaterials for high-end sophisticated applications continues to be on the rise and have a substantial impact on our everyday life. Since nanomaterials tend to have increased reactivity, there are some concerns related to toxicity as well as induction of oxidative stress in biological systems. Therefore, interdisciplinary studies assessing the safety and efficacy of nanomaterials is crucial for the development of nanotechnology.

9:30 am - 10:00 am   
Redox-Nanomaterial and DNA Oxidative Damage
Bryant C. Nelson, PhD, National Institute of Standards & Technology, USA

10:00 am - 10:30 am
Metal-Based Nanotherapeutics
Shanta Dhar, PhD, University of Miami, USA

10:30 am - 11:00 am
BREAK

11:00 am - 11:30 am 
Nanotherapies for Treatment of Cardiovascular Disease
Edward Moreira Bahnson, PhD, University of North Carolina at Chapel Hill, USA

11:30 am - 12:00 pm     
Tuning Functional Carbon Nanodots and the Oxidative Stress Effect in Living Cells
Jianjun Wei, PhD, Joint School of Nanoscience and Nanoengineering, USA

12:00 pm - 12:30 pm
New Member Welcome Meeting

12:00 pm - 2:30 pm
Lunch
Attendees on own

2:30 pm - 4:15 pm
Oral Presentations from Submitted Abstracts
3 concurrent sessions

4:15 pm - 6:45 pm
Formal Poster Presentations

7:30 pm - 9:30 pm
Closing Awards Banquet

9:30 pm - 11:00 pm
Hospitality

SfRBM 2020 officially adjourns after the Closing Awards Banquet on Saturday, November 21.