Virtual Conference Program

Wednesday, November 18 - Live
Thursday, November 19 - Live
Friday, November 20 - Live
OnDemand Content

LIVE SESSIONS

WEDNESDAY, NOVEMBER 18, 2020

INTRODUCTION 
11:00 am - 11:15 am
SfRBM President's Welcome / Year in Review
Phyllis Dennery, MD, Brown University / Rhode Island Hospital, USA
SfRBM President

 

PRESIDENTIAL PLENARY SESSION
11:15 am - 11:45 am
Melatonin, Oxidative Stress and COVID-19
Russel Reiter, PhD, University of Texas Health Science Center, USA

11:45  am - 12:15 pm
Speaker TBD

12:15 pm - 12:45 pm
Break and Visit Virtual Exhibits
 

PLENARY SESSION 1
Redox Activity of Engineered Nanomaterials: Safety and Biomedical Application
Chairs: Karina Ckless, PhD, SUNY Plattsburgh, USA and Darlene Taylor, PhD, North Carolina Central University, USA

The development of new engineered nanomaterials for high-end sophisticated applications continues to be on the rise and have a substantial impact on our everyday life. Since nanomaterials tend to have increased reactivity, there are some concerns related to toxicity as well as induction of oxidative stress in biological systems. Therefore, interdisciplinary studies assessing the safety and efficacy of nanomaterials is crucial for the development of nanotechnology.

12:45 pm - 1:15 pm
Redox-Nanomaterial and DNA Oxidative Damage
Bryant C. Nelson, PhD, National Institute of Standards & Technology, USA

1:15 pm - 1:45 pm
Metal-Based Nanotherapeutics
Shanta Dhar, PhD, University of Miami, USA

1:45 pm - 2:15 pm
Nanotherapies for Treatment of Cardiovascular Disease
Edward Moreira Bahnson, PhD, University of North Carolina at Chapel Hill, USA

2:15 pm - 2:45 pm
Tuning Functional Carbon Nanodots and the Oxidative Stress Effect in Living Cells
Jianjun Wei, PhD, Joint School of Nanoscience and Nanoengineering, USA

2:45 pm - 3:15 pm
Break and Visit Virtual Exhibits
 

PROFESSIONAL DEVELOPMENT SESSIONS 
3:15 pm - 4:15 pm
Session 1: The Art of the Interview Chalk Talk
Adam Case, PhD, University of Nebraska Medical Center, USA
Damian Guerra, PhD, University of Louisville, USA
Samantha Mooga, PhD, University of Alabama at Birmingham, USA


3:15 pm - 4:15 pm
Session 2: Speed Mentoring
Rajasekaran Namakkal Soorappan, M.Phil., PhD, University of Alabama at Birmingham, USA
Ben Boivin, PhD, SUNY Polytechnic Institute, USA

THURSDAY, NOVEMBER 19, 2020

PLENARY SESSION 2
Where We Begin Matters: Influence of Oxidative Stress in the Developmental Origins of Adult Disease
Chairs: Peter Vitiello, PhD, University of Oklahoma, USA and Lin Mantell, MD, PhD, St. John's University College of Pharmacy/Northwell Health System, USA

Though the concept of developmental origins of health and disease is not new, redox perturbations during fetal and perinatal development are increasingly recognized as a key factor for numerous adult diseases. This session will discuss mechanisms by which early life exposure to oxidative stress affects development and adult disease through dysfunctional redox signaling, metabolic reprogramming, and epigenetic modifications.

11:00 am - 11:30 am
Unique Age-Dependent Redox-Responses to Oxidant Lung Injury
Eva Nozik-Grayck, MD, University of Colorado Anschutz Medical Center, USA

11:30 am - 12:00 pm
Neonatal Hyperoxia Causes Adult Disease by Reprogramming Cellular Metabolism
Michael A. O'Reilly, PhD, The University of Rochester Medical Center, USA

12:00 pm - 12:30 pm
Understanding Aging Through the Prism of Alveolar Macrophages - How Mitochondria Matter
G.R. Scott Budinger, MD, Northwestern University, USA

12:30 pm - 1:00 pm
Redox Mechanism for the Beneficial Effect of Maternal Exercise to Improve Offspring Metabolic Health
Laurie Goodyear, PhD, Harvard Medical School, USA

1:00 pm - 1:30 pm

Break and Visit Virtual Exhibits
 

PLENARY SESSION 3
The Janus Face of Sirtuins in Health and Cancer
Chairs: Nadine Hempel, PhD, Penn State University College of Medicine and Doris Germain, PhD, Mount Sinai Icahn School of Medicine

The acetylome has emerged as a major point of integration between metabolism, redox homeostasis and cellular reprogramming in health and disease. Novel research highlighted in this session demonstrates that Sirtuin (SIRT) deacetylases, the acetylation state of some sirtuin target proteins and the subsequent changes in oxidants and metabolism are intimately connected with cancer progression. It has come to light that the role of sirtuin enzymes is often context dependent and that this dictates their dichotomous function in cancer initiation and metastatic progression. Our plenary talks highlight this Janus face of sirtuins, focusing on their regulation and role during tumorigenesis, metastasis, stem cell reprogramming and the development of chemotherapy resistance.

1:30 pm - 2:00 pm
Sirtuins Connect Longevity, Health and Cancer Via Regulating of the Mitochondrial Acetylome
David Gius, MD, PhD, Northwestern University, Chicago, IL

2:00 pm - 2:30 pm
The SIRT3 Axis of the Mitochondrial UPR Up-Regulates SOD2 and Promotes Metastasis
Doris Germain, PhD, Mount Sinai Icahn School of Medicine, New York, NY

2:30 pm - 3:00 pm
Sittuins in Cancer
Marcia Haigis, PhD, Harvard Medical School, USA

3:00 pm - 3:30 pm
Transient Changes in SIRT3 and SOD2 Drive Anchorage Independent Survival and Ovarian Cancer Metastasis
Nadine Hempel, Pennsylvania State University, Hershey, PA

3:30 pm - 4:00 pm
Break and Visit Virtual Exhibits

OPENING DOORS EVENT
4:00 pm - 5:15 pm
Leading by Example - Fostering Safe and Inclusive Research and Training Environments
Yvette Seger, PhD, Office of Public Affairs/FASEB, USA
Charlene Le Fauve, PhD, Scientific Workforce Diversity National Institutes of Health, USA

Sonia Flores, PhD, University of Colorado Anschutz Medical Campus, USA
 

FRIDAY, NOVEMBER 20, 2020

PLENARY SESSION 4
Cellular Microdomains for Redox Signaling in the Vasculature
Chairs: Brant E. Isakson, PhD, University of Virginia, USA and Miriam M. Cortese-Krott, PhD, University of Düsseldorf, Germany

There is accumulating evidence that biological membranes are highly organized in microdomains. Recent evidence demonstrated that microdomains are crucial for organizing and compartmentalizing redox signals particularly in the vascular system and thereby may contribute to blood pressure control and cardiovascular homeostasis. In this session, we aim to describe how membrane microdomains in both the endothelium and red blood cells allow context-specific regulation of signaling of reactive species, including nitric oxide (and its metabolites) and hydrogen peroxide and how this results in tightly controlled systemic physiological responses.

11:00 am - 11:30 am
Heme Redox Control in the Vascular Wall
Adam Straub, PhD, University of Pittsburgh, USA

11:30 am - 12:00 pm
Cellular Microdomains for Nitric Oxide and Redox Signaling in Red Blood Cells
Kathrin Schröder, PhD, University of Frankfurt, Germany

12:00 pm - 12:30 pm
Redox Signaling in Endothelial Cell Microdomains
Swapnil Sokusare, PhD, University of Virginia, USA

12:30 pm - 1:00 pm
Title TBD
Miriam M. Cortese-Krott, PhD, University of Düsseldorf, Germany

1:00 pm - 1:30 pm
Break and Visit Virtual Exhibits
 

PLENARY SESSION 5
Peroxynitrite and Tyrosine Nitration: From Biomarker of Oxidative Stress to Signaling Molecule
Chairs: Joe Beckman, PhD, Oregon State University, USA and Maria Clara Franco, PhD, Oregon State University, USA

Tyrosine nitration is detected in most pathologies associated with inflammation, including cancer and neurodegeneration. The discovery of nitrated proteins that play pathological roles, and reports of cellular denitrase activity, reveal that tyrosine nitration is an oxidative posttranslational modification capable of regulating signaling pathways, posing nitrated proteins as a new category of potential targets for therapeutic development.

1:30 pm - 2:00 pm
Alternative Conformations and Functions of Cytochrom C: Lessons from Tyrosine Nitration Studies
Rafael Radi, MD, PhD, Universidad de la República, Uruguay

2:00 pm - 2:30 pm
Apoptotic Signaling Pathways Activated by Peroxynitrite-Mediated Nitration
Alvaro Estevez, PhD, Oregon State University, USA

2:30 pm - 3:00 pm
Denitrase Activity of the PTPRT Psuedo-Phosphatase Domain
Zhenghe Wang, PhD, Case Western Reserve University, USA

3:00 pm - 3:30 pm
Nitrated Proteins as Tumor-Directed Targets
Maria Clara Franco, PhD, Oregon State University, USA

3:30 pm - 4:00 pm
Break and Visit Virtual Exhibits
 

PROFESSIONAL DEVELOPMENT SESSIONS
4:00 pm - 5:00 pm
Session 3: TBD
Sophie Maiocchi, PhD, University of North Carolina, Chapel Hill
Trainee Council

4:00 pm - 5:00 pm
Session 4: What's Your Negotiation Strategy?
Carola Neumann, MD, University of Pittsburgh, USA
Peter Vitiello, PhD, Sanford Research, USA

 

ON DEMAND

*E-Posters with audio and sessions below available throughout conference

SUNRISE FREE RADICAL SCHOOL
Back to the Basics
Chairs: Kimberly Dunham-Snary, Ph.D., Queen's University, Canada and Carola Neumann, MD, University of Pittsburgh, USA

  • Nanomaterial Categorization by Surface Reactivity: A Case Study Comparing 35 Materials with Four Different Test Methods
    Andrea Haase, PhD, German Federal Institute for Risk Assessment (BfR), Germany
     
  • Yin and Yang of Immune Function in Developmental Programming
    Rebecca Simmons, MD, Pennsylvania School of Medicine, USA
     
  • The Yins and Yangs of Sirtuins in Malignancy
    David Lombard, MD, PhD, University of Michigan, USA
     
  • Cellular Microdomains for Redox Signaling in the Vasculature
    Brant Isakson, PhD, University of Virginia School of Medicine, USA
     
  • Peroxynitrite and Tyrosine Nitration: Biochemistry and Biological Consequences 
    Ana Denicola, PhD, Universidad de la República - Uruguay


PRE-CONFERENCE SESSION - ON DEMAND
Redoxomics in the 21st Century: From Chemistry to Chromatin
Chairs: Kimberly Dunham-Snary, PhD, Queen's University, Matthew Ryan Smith, PhD, Emory University, and Frederick Domann, PhD, F-SfRBM, University of Iowa

Advances in the field of systems biology have led to the generation and analysis of large datasets allowing numerous novel discoveries in human physiology and the pathogenesis of disease. The application of ‘omics technologies have provided better understanding of the complexity in cellular signalling networks and opened a new avenue of investigation in the field of redox biology. Other ‘omics’ platforms have been widely applied in the fields of cardiovascular disease, cancer, and stem cell research, but there remains tremendous potential in the field of redox biology. Integrating these various platforms is the critical next step to elucidate the cellular mechanisms of redox signaling and to understand the true complexity of human physiology. This session will assemble numerous leading experts in the fields of epigenomics, metabolomics, lipidomics, redox biology and systems biology to: i) provide insights into the integration of our current understanding of redox biology with these state-of-the-art tools, ii) challenge our understanding of how remarkable cellular networks truly interact, and iii) provide the framework for potential new discoveries of the Redox-ome.

  • 'Ome is Where the Heart is
    Charles Hindmarch, PhD, Queen's University, Queen's Cardiopulmonary Unit, & Translational Institute of Medicine, Canada
     
  • Oxylipidomics and Redox-Systems Biology in Blood-Clotting
    Valerie O'Donnell, PhD, Cardiff University, UK
  • Redox Metals at the Interface of the Metabolome, Exposome and Genome
    Dean Jones, PhD, Emory University, USA
     
  • Epitranscriptomic Regulation of Selenoprotein Translation and Consequences for ROS Detoxification
    Thomas Begley, PhD, University of Albany SUNY, USA
     
  • The Exposome: From Molevcules to Populations
    Gary Miller, PhD, Columbia University, USA
     
  • Epigenetics, the Third Pillar of Nitric Oxide Signaling
    Douglas Thomas, PhD, University of Illinios at Chicago, USA
     
  • Dynamic Regulation of Epigenetic Demethylation by Oxygen Availabilty
    Alison Brewer, PhD, King's College London, UK
     
  • cAMP Signaling and Labile Fe(II) in Epigenomic Regulation
    Gaofeng Wang, PhD, University of Miami, USA
     
  • Mitochondrial Control of Nuclear Epigenetic Reprogramming
    Janine Santos, PhD, National Institutes of Health, USA
     
  • Regulation of DNA Methylation by Immune Cell Oxidants
    Mark Hampton, PhD, University of Otago, Christchurch, New Zealand

SfRBM LIFETIME ACHIEVEMENT AWARD LECTURE
A Lifetime with DNA and RNA Oxidation

Henrik Poulsen, MD, University of Copenhagen, Denmark

ORAL PRESENTATIONS FROM SUBMITTED ABSTRACTS
9 thematic sessions