Conference Program

Daily Schedules

Wednesday
  Full Day Pre-Meeting Workshop
  Half-Day Pre-Meeting Workshop
  Opening Session
Thursday
Friday
Saturday

TUESDAY, NOVEMBER 13, 2018

5:00 pm – 8:00 pm
Registration/Information Desk

WEDNESDAY, NOVEMBER 14, 2018

7:00 am – 6:30 pm
Registration/Information Desk

FULL DAY PRE-MEETING WORKSHOP
8:00 am – 3:15 pm
Oxidative Stress and Signaling: Methods, Mechanisms, and Therapeutics
Chairs: Sruti Shiva, Ph.D., University of Pittsburgh, USA and Rakesh Patel, Ph.D., University of Alabama at Birmingham, USA

This workshop brings together leading biologists, chemists and physiologists with redox expertise to provide an overview of cutting-edge methodology in the field, prevailing mechanistic concepts, and the latest redox-based therapeutic approaches.  While speakers in this session have a cardiovascular slant, the information presented will cross disciplines and be of value to both budding and experienced redox researchers.
8:15 am – 9:45 am  |  Session 1: Measurement of Oxidative Stress in Vivo

8:15 am – 8:45 am
Mass Spectrometry Imaging of Lipid Peroxidation
lya Bayir, MD, University of Pittsburgh, USA

8:45 am – 9:15 am 
EPR Based Imaging of Oxygen Gradients in Vivo
Murali Cherukuri, Ph.D., NIH/NCI, USA 

9:15 am – 9:45 am
High Resolution NMR and Imaging of Cardiac Metabolism
Rong Tian, MD, Ph.D., University of Washington, USA

9:45 am – 10:15 am | Break

10:15 am – 12:15 pm  |  Session 2: Thiol Oxidation, Nitrosation and Sulfhydration

10:15 am – 10:45 am
Measurement of S-Nitrosation in Cardioprotection
Elizabeth Murphy, Ph.D., NIH/NHLBI, USA

10:45 am – 11:15 am
Post-translational Modifications of Protein Thiols - From Detection to Biological Significance
Phil Eaton, Ph.D., King's College London, UK

11:45 am – 12:15 pm
Sulfide and Perthiol Measurement and Signaling in Disease Models
Christopher Kevil, Ph.D., Louisiana State University, USA

12:15 pm – 1:30 pm | Lunch

1:30 pm – 3:15 pm |  Session 3: Redox Based Therapeutics and Metabolomics

1:30 pm – 2:00 pm
Antioxidant Therapeutics for Islet Transplantation
Hubert Tse, Ph.D., University of Alabama at Birmingham, USA

2:00 pm – 2:30 pm    
Integration of Flux Methodologies for Understanding Metabolism
Bradford Hill, Ph.D., University of Louisville, USA

2:30 pm – 3:00 pm
Mitochondrial Targeted Redox Modulators as Therapeutic Agents
David Brown, Ph.D., Virginia Tech, USA

3:00 pm – 3:15 pm
Closing Remarks

HALF-DAY PRE-MEETING WORKSHOP
1:00 pm - 3:30 pm
Methods in Lipid Oxidation
Chairs: Henry Jay Forman, Ph.D., University of Southern California, USA and Corinne Spickett, MA, DPhil, Aston University, UK

Lipid oxidation generates numerous bioactive products, which can act as either signaling molecules involved in cell growth regulation, and stimulants of increased antioxidant defense, or signal for and participate in cell death. Hence, various acute and chronic human diseases metabolic, degenerative, inflammatory and malignant are associated with lipid oxidation. Therefore, this workshop will give an updated overview on methods in lipid oxidation research that might clarify the most relevant aspects of lipid oxidation and support its positioning within the interdisciplinarity of free radical biology and medicine.

1:00 pm – 1:10 pm
Welcome

1:10 pm – 1:40 pm    
MS-Based Identification of Covalent Adducts in Oxidized LDL
Koji Uchida, Ph.D., The University of Tokyo, Japan

1:40 pm – 2:10 pm    
Methods to Measure Isolevuglandin Protein and Phospholipid Adducts
Sean Davies, Ph.D., Vanderbilt University, USA

2:10 pm – 2:25 pm | Break

2:25 pm – 2:55 pm
Immunochemical Findings of HNE-His Adducts in Human Diseases
Neven Zerkovic, MD, Ph.D., Rudjer Boskovic Institute, Croatia

2:55 pm –  3:25 pm
Nitro-fatty Acids: Detection, Electrophilic Signaling and Therapeutics
Homero Rubbo, Ph.D., Universidad de la República, Uruguay

3:25 pm – 3:30 pm
Summary


ANNUAL CONFERENCE BEGINS

5:30 pm - 7:30 pm
Opening Session

5:30 pm – 5:40 pm
SfRBM President's Welcome
Rick Domann Ph.D., The University of Iowa, USA, SfRBM President 

PRESIDENTIAL PLENARY SESSION 
5:40 pm - 7:10 pm
Redox Modulation of Hypertension
Chair: Christopher Kevil, Ph.D., Louisiana State University, USA

5:40 pm – 6:10 pm     
Regulation of Vessel Tone by Heme Globins
Brant Isakson, Ph.D., University of Virginia, USA

6:10 pm – 6:40 pm     
Inorganic Nitrate as a Regulator of Vascular Function
Amrita Ahluwalia, Ph.D., William Harvey Research Institute, UK

6:40 pm – 7:10 pm     
Redox Signaling in the Brain and Antioxidant-Based Therapeutics: Consequences for Hypertension
Matthew Zimmerman, Ph.D., University of Nebraska Medical Center, USA

7:15 pm – 9:00 pm     
Welcome Reception

7:15 pm – 8:30 pm 
Trainee Welcome Event

9:00 pm – 11:00 pm
Hospitality


THURSDAY, NOVEMBER 15, 2018

7:00 am - 6:30 pm
Registration/Information Desk

SUNRISE FREE RADICAL SCHOOL
8:00 am - 9:00 am
Back to the Basics
Chairs: Ralf Brandes, MD, Goethe-University, Frankfurt am Main, Germany and Jianhua Zhang, Ph.D., University of Alabama at Birmingham, USA

8:00 am – 8:30 am
Oxygen Chemistry: ROS, Radical, Reactivity
Douglas Spitz, Ph.D., The University of Iowa, USA

8:30 am – 9:00 am
Sources of ROS: Mito, Nox and NOS
Flavia Rezende, Ph.D., Goethe-University, Frankfurt am Main, Germany

PLENARY SESSION 1
9:30 am - 12:00 pm
Advances in Cysteine-Based Redox Signaling Mechanisms
Chairs: Leslie Poole, Ph.D., Wake Forest School of Medicine, USA and Ben Boivin, Ph.D., SUNY Polytechnic Institute, USA

At the center of redox signaling are oxidoreductive chemical reactions involving low and moderate levels of reactive oxygen species and reductants that modify the thiol-side chain of cysteinyl residues in proteins. In turn, these post-translational modifications cause a spectrum of structural alterations that allow reactive oxygen species production to be coupled to functional outputs in the cell. This session discusses timely and exciting advances in methodological approaches that allow targeted oxidation and monitoring of these cysteine-switches in redox signaling.

9:30 am – 10:00 am   
Targetable Reactive Electrophiles and Oxidants (T-REX) Technology to Identify "Privileged" Redox Sensors
Yimon Aye, Ph.D., Cornell University, USA

10:00 am – 10:30 am
Identification and Analysis of Thiol-Based Signaling Complexes
Tobias Dick, Ph.D., German Cancer Research Center (DKFZ), Germany

10:30 am – 11:00 am | Break

11:00 am – 11:30 am
Redox Modification of the Cytoskeleton During Cell Adhesion and Migration
Kathy Griendling, Ph.D., Emory University, USA

11:30 am - 12:00 pm 
Assessing the Impact of Redox Modification on the Global Substrate Selection of Protein Kinases
Robert Newman, Ph.D., North Carolina Agricultural and Technical State University, USA

PLENARY SESSION 2
9:30 am - 12:00 pm
Nutrition and Redox Signaling: From Nutrients to Bioactives
Chairs: Cesar G. Fraga, Ph.D., University of Buenos Aires, Argentina and Enrique Cadenas, MD, Ph.D., University of Southern California, USA

This session focuses on how both nutrients and bioactives can prevent or ameliorate disease through mechanisms involving the modulation of redox cell signaling. These mechanisms entail nutrient sensing by redox modulation of functional proteins that impinge on the balance of energy intake and expenditure and they underscore the impact of bioactives controlling pathways leading to metabolic, neurological and cardiovascular dysfunction.

9:30 am – 10:00 am
Mitochondria, Nrf2 and mTOR
Gino Corotpassi, Ph.D., University of California, Davis, USA

10:00 am – 10:30 am
Plant Bioactives and the Intestinal Barrier: Redox Signaling and Implications for Insulin Resistance
Patricia I. Oteiza, Ph.D., University of California, Davis, USA

10:30 am – 11:00 am | Break

11:00 am – 11:30 am 
The Impact of Polyphenols on Human Vascular and Cognitive Health: The Role of Intracellular Signaling
Jeremy P. E. Spencer, Ph.D., University of Reading, UK

11:30 am – 12:00 pm             
Regulation of HO-1 by Flavonoids: Mechanisms and Health Possibilities
Kevin Croft, Ph.D., University of Western Australia, Australia

12:00 pm - 12:30 pm
SfRBM Year in Review: Annual Member Meeting

12:15 pm - 1:30 pm
SPECIAL SESSION | WATER TOWER PARLOR
Physiological Oxygen Cell Culture - A Growing Trend in Tissue/Cell Culture

Krista Rantanen, Ph.D., Science Applications Director, Baker Ruskinn and Samir Patel, Global Sales Director, Baker Ruskinn

Click here to register for this session.
Lunch will be provided to all session attendees.

12:30 pm - 2:30 pm | Lunch
Attendees on own

1:00 pm – 2:15 pm
Professional Development Session I 
Not Enough Hours in the Day - AKA How to Say NO!
Discussion will include topics such as: Strategies to boost efficiency by prioritizing, establising concentration windows, dealing efficiently with email, and how to say no to avoid over commitment. This session will cover how to deal with time pressures in all stages of career including graduate life, the pre-tenure time frame, and balancing teaching with research.

1:00 pm – 2:15 pm
Professional Development Session II
In the Land of -omics
This session will include an expert panel of researchers familiar with -omics projects who will discuss tools and strategies to deal with big data. Topics covered include: Common misconceptions and statistical/analytical errors to avoid, resources and access to bioinformatics tools, analytical strategies to make sense of data using more common tools.

2:30 pm – 4:15 pm
Oral Presentations from Submitted Abstracts
3 concurrent sessions

4:15 pm – 6:45 pm
Formal Poster Presentations

6:45 pm – 9:00 pm
Opening Doors Event
Everyone Needs a Yoda: The Importance of Mentors Throughout Your Scientific Career

9:00 pm – 11:00 pm
Hospitality


FRIDAY, NOVEMBER 16, 2018

7:00 am - 6:30 pm
Registration/Information Desk

SUNRISE FREE RADICAL SCHOOL
8:00 am - 9:00 am
Back to the Basics
Chairs: Ralf Brandes, MD, Goethe-University, Frankfurt am Main, Germany and Jianhua Zhang, Ph.D., University of Alabama at Birmingham, USA

8:00 am – 8:30 am
Thiol Chemistry and Reactivity
Reto Asmis, Ph.D., Wake Forest University, USA

8:30 am – 9:00 am
Principles of Redox Regulation - The Thiol Worlds
Dean Jones, Ph.D., Emory University, USA

PLENARY SESSION 3
9:30 am - 12:00 pm
Regulatory Role of RNA / DNA Oxidation and its Functional Significance in Disease
Chairs: Clare Hawkins, Ph.D., University of Copenhagen, Denmark and Henrik Poulsen, MD, University Hospital Copenhagen, Denmark

The modification of RNA and DNA during oxidative stress is generally regarded as being detrimental to cellular processes, with the formation of modified nucleobases in vivo, particularly 8-oxo-7,8-dihydro-2’-deoxyguanosine (8-oxodG), strongly linked to mutations and decreased gene transcription. This symposium will highlight newly discovered regulatory and epigenetic implications of DNA oxidation and 8-oxodG formation, together with discussing the functional and clinical significance of RNA oxidation.

9:30 am – 10:00 am
8-oxoxG Formation: Impact in Gene Promoters on Gene Transcription and Mapping Studies
Cynthia Burrows, Ph.D., University of Utah, USA

10:00 am – 10:30 am 
The Impact of Oxidative DNA Lesions on Telomere Maintenance
Patty Opresko, Ph.D., University of Pittsburgh, USA

10:30 am – 11:00 am | Break

11:00 am – 11:30 am
Cellular Consequences and Repair of Oxidised RNA
Hani Zaher, Ph.D., Washington University, USA

11:30 am - 12:00 pm 
Oxidative Stress to RNA / DNA in the Clinical Setting: Clinical Intervention Trials and Epidemiology
Henrik Poulsen, MD, University Hospital Copenhagen, Denmark

PLENARY SESSION 4 
9:30 am - 12:00 pm
Redox Metabolism in Cancer Stem Cell State Switching
Chairs: Michael Graham Espey, Ph.D., National Cancer Institute, USA and Douglas Thomas, Ph.D., University of Illinois at Chicago, USA

This session will delve into the roles metabolism and redox crosstalk plays in the determination of cellular identity rooted in the concept of cancer stem cell states.  Speakers represent the integrative nature of these regulators in normal physiology and the mechanistic underpinnings of their dysregulation across diverse types of cancer.  How metabolic reprogramming can drive heterogeneity and resistance will be explored.  This plenary session also highlights how investigation of basic redox processes/mechanisms can be used as the basis for translation of new therapeutic strategies.

9:30 am – 10:00 am
Metabolic Regulation of Cell State
Heather Christofk, Ph.D., University of California, Los Angeles, USA

10:00 am – 10:30 am
PGC1α at the Nexus of Cancer Stem Cell Fates
Pere Puigserver, Ph.D., Harvard Medical School, USA

10:30 am – 11:00 am | Break

11:00 am – 11:30 am
Social Behavior of Breast Cancer Stem Cells in Metastasis
Huiping Liu, MD, Ph.D., Northwestern University Feinberg School of Medicine, USA

11:30 am – 12:00 pm 
Mitochondrial Regulation of Normal and Leukemic Stem Cells
Saghi Ghaffari, MD, Ph.D., Icahn School of Medicine at Mount Sinai, USA

12:00 pm – 12:30 pm     
SfRBM Lifetime Achievement Award Lecture
MnSOD at the Crossroads of Life and Death: We've Only Just Begun
Daret St. Clair, Ph.D., University of Kentucky, USA

12:30 pm – 2:30 pm | Lunch 
Attendees on own

1:00 pm – 2:15 pm
Professional Development Session III
Grantsmanship Workshop
Selected specific aims pages from participants will be discussed anonymously by a mock NIH study section panel.

1:00 pm – 2:15 pm
Professional Development Session IV
AMA (Ask Me Anything)
This session will include a speaker panel of professionals from an array of career paths and fields (academia, industry, policy, teaching, health care) and career stages (junior and senior). 

2:30 pm – 4:15 pm
Oral Presentations from Submitted Abstracts
3 concurrent sessions

4:15 pm – 6:45 pm
Formal Poster Presentations

7:00 pm – 8:00 pm 
FRBM & Redox Biology Editors Reception

9:00 pm – 11:00 pm
Hospitality


SATURDAY, NOVEMBER 17, 2018

7:00 am - 6:30 pm
Registration/Information Desk

SUNRISE FREE RADICAL SCHOOL 
8:00 am - 9:00 am
Back to the Basics
Chairs: Ralf Brandes, MD, Goethe-University, Frankfurt am Main, Germany and Jianhua Zhang, Ph.D., University of Alabama at Birmingham, USA

8:00 am – 8:30 am
Small Molecules Antioxidants
Manisha Patel, Ph.D., University of Colorado Anschutz Medical Campus, USA

8:30 am – 9:00 am
Nitric Oxide: The "Good" ROS
Sruti Shiva, Ph.D., University of Pittsburgh, USA

PLENARY SESSION 5
9:30 am - 12:00 pm
Targeted and Local Delivery of Redox Therapeutics: Intervention Where it Matters
Chairs: Edward Moreira Bahnson, Ph.D., University of North Carolina, USA and Francis Miller, MD, Duke University, USA

Despite the contribution of redox dysfunction to the pathophysiology of multiple diseases, the efficacy of antioxidants as therapies has been disappointing. A fundamental limitation of these therapeutic approaches has been their method of delivery. Localized redox dysfunction necessitates the development of local targeted therapeutic strategies that deliver the redox intervention directly to the cellular and/or subcellular site of disease.   

9:30 am – 10:00 am   
Local and Targeted Redox Therapies for the Vasculature
Edward Moreira Bahnson, Ph.D., University of North Carolina, USA

10:00 am – 10:30 am
Cell-Mediated Delivery of Catalase to the CNS
Elena Batrakova, Ph.D., University of North Carolina, USA
                        
10:30 am – 11:00 am | Break

11:00 am – 11:30 am 
Measurement of Real-time Nitric Oxide (NO) Release from Macrophages, Fibroblasts and Keratinocytes to Direct the Development of Smart Dressings for Diabetic Foot Ulcers
Megan C. Frost, Ph.D., Michigan Technological University, USA

11:30 am  - 12:00 pm     
Harnessing the Therapeutic Potential of Nitric Oxide Through Nanoparticle Technology
Joel M. Friedman, MD, Ph.D., Albert Einstein College of Medicine, USA

12:00 pm – 12:30 pm
New Member Welcome Meeting

12:00 pm – 2:30 pm | Lunch
Attendees on own

2:30 pm – 4:15 pm
Oral Presentations from Submitted Abstracts
3 concurrent sessions

4:15 pm – 7:00 pm
Formal Poster Presentations

7:30 pm – 9:30 pm
Closing Awards Banquet

9:30 pm - 11:00 pm
Hospitality

SfRBM 2018 officially adjourns after the Closing Awards Banquet on Saturday, November 17. There will not be a Sunday Plenary Session.

updated 6/20/18