Page 15 - SFRBMdot - December 2014

Free Radical School Virtual Seminar Series

SFRBM offers virtual programming on a quarterly basis, providing valuable education on a wide

range of topics. The sessions are open to SFRBM members only and are offered at no charge.

PEROXIREDOXIN: PEROXIDASE, REGULATOR ABOUT THE SPEAKER

AND SENSOR OF LOCAL PEROXIDES, AND

PROTEIN CHAPERONE
Sue Goo Rhee, Ph.D. is a Distinguished Professor at Yonsei University

College of Medicine, Yonsei Biomedical Research Institute. His group
Thursday, January 22, 2015
discovered a family of peroxiredoxin (Prx) that catalyzes reduction
10:00 am Eastern (15:00 GMT/UTC)
of H2O2 and established that mammalian cells express six distinct Prx
Speaker: Sue-Goo Rhee, Ph.D.,
enzymes that not only protect against oxidative damage but also mediate
Yonsei University College of Medicine
cell signaling by modulating intracellular H2O2 levels. We showed that

Cost: FREE for SFRBM members
growth factors (EGF) induce a transient increase in intracellular H2O2

levels and that the essential cysteine of protein tyrosine phosphatases

is the target of speciic, reversible oxidation by H2O2 produced in

cells stimulated with growth factors. These observations led to a new

paradigm in receptor signaling wherein protein tyrosine phosphorylation

is achieved not via activation of receptor protein tyrosine kinases alone,

but through concurrent inhibition of protein tyrosine phosphatases by
PROGRAM OVERVIEW
H2O2. Our studies revealed that Prx isozymes are extensively regulated

via phosphorylation as well as hyperoxidation of the active site cysteine to Peroxiredoxins are a ubiquitous family of

peroxidases that are found from bacteria to
cysteine sulinic acid, with the reverse reaction catalyzed by suliredoxin.
humans and contain an active site cysteine that is
The reversible Prx cysteine hyperoxidation discovered by us proved

critical for feedback regulation of steroidogenesis and constitutes a sensitive to oxidation by peroxides. Peroxiredoxin

universal marker for circadian rhythms in all domains of life.
not only function as peroxide-eliminating

enzymes but also as sensors and regulators

of local peroxides and as protein chaperones.

These functions are regulated through various

LATEST ARCHIVED WEBINAR
Sue Goo Rhee, Ph.D.
posttranslational modiications such as tyrosine

and threonine phosphorylation, lysine acetylation,
PLEIOTROPIC ANTI-INFLAMMATORY
or active site cysteine hyperoxidation. The peroxiredoxin regulatory
SIGNALING ACTIONS OF REDOX-DERIVED
mechanisms will be discussed in the context of the control of growth
FATTY ACID ELECTROPHILES
factor signaling, steroidogenesis, metabolism, and circadian rhythm.

Speaker: Bruce Freeman, Ph.D.

Originally presented October 29, 2014

SFRBM Newsletter // December 2014 // Free Radical School Virtual Seminar Series

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