Full Meeting Program

TUESDAY, NOVEMBER 28, 2017

REGISTRATION/INFORMATION DESK
5:00 pm - 8:00 pm  |  Key Ballroom Foyer

WEDNESDAY, NOVEMBER 29, 2017

REGISTRATION/INFORMATION DESK
7:00 am - 6:30 pm  |  Key Ballroom Foyer

PRE-MEETING WORKSHOP
Full Day Pre-Meeting Workshop
Basic to Translational Understanding in Redox Physical Oncology | 8:00 am – 3:45 pm | KEY BALLROOM 
Chair: Michael Graham Espey, Ph.D., NIH, USA

This workshop is designed to explore the concept of Redox Physical Oncology. The use of advanced technologies to study and understand the roles of redox effectors in cancer processes will be highlighted in sessions that span both basic mechanistic studies and translational work on tumor cells and physical microenvironment dynamics. 

8:00 am – 8:15 am  |  Welcome
Rick Domann, Ph.D., The University of Iowa, USA and Paul Rothman, MD, Johns Hopkins University School of Medicine, USA

8:15 am – 10:30 am  |  SESSION 1: Cancer Redox Cartography
Session Chairs: Rick Domann, Ph.D., The University of Iowa, USA and Zaver M. Bhujwalla, Ph.D., Johns Hopkins University School of Medicine, USA

8:15 am – 8:50 am
The Cancer Metallome
Thomas O’Halloran, Ph.D., Northwestern University, USA

8:50 – 9:25 am 
Spatial Dynamics in Redox Systems Biology
Melissa Kemp, Ph.D., Georgia Institute of Technology, USA 

9:25 am – 9:45 am | Break

9:45 – 10:25 am
New Dimensions in Hypoxia and Cancer Metastasis
Andrew Ewald, Ph.D., Johns Hopkins University School of Medicine, USA and Daniele Gilkes, Ph.D., Johns Hopkins University School of Medicine, USA

10:25 – 11:00 am
In Vivo Imaging of Metastasis
John Condeelis, Ph.D., Albert Einstein College of Medicine, USA

11:00 – 12:10 pm  |  SESSION 2: Translation of Redox Physical Oncology
Session Chair:  Kenneth Pienta, MD, Johns Hopkins University School of Medicine, USA

11:00 – 11:35 pm
Challenges in Oxygen and Redox Modifiers
Mark Dewhirst, DVM, Ph.D., Duke University, USA

11:35 – 12:10 pm    
Drugging the Tumor Microenvironment
Amato Giaccia, Ph.D., Stanford University, USA

12:10 pm - 1:00 pm  |  Meet the Expert Lunch           

1:00 – 3:40 pm  |  SESSION 3: Cancer Cell Biology Dynamics
Session Co-Chairs:  Sharon Gerecht, Ph.D., Johns Hopkins University School of Medicine, USA and Michael Graham Espey, Ph.D., NCI, USA

1:00 – 1:35 pm
Metabolic Reprogramming and Tumor Hypoxic Stresses
M. Celeste Simon, Ph.D., University of Pennsylvania, USA

1:35 – 2:10 pm    
The Mito-Metastasis Axis
Dario Altieri, MD, The Wistar Institute Cancer Center, USA

2:10 – 2:30 pm  |  Break

2:30 – 3:05 pm    
Roles of Mitochondria in Quality Control & Asymmetry in Cancer
Rong Li, Ph.D., Johns Hopkins University School of Medicine, USA

3:05 – 3:40 pm
Born Different:  Metabolic Maintenance of Asymmetric Cell Division
Douglas Green, Ph.D., St. Jude Children's Research Hospital, USA

3:40 – 3:45 pm
NCI Funding Opportunities
Michael Graham Espey, Ph.D., NCI, USA

3:45 pm  |  Closing Remarks and Adjournment
Rick Domann, Ph.D., The University of Iowa, USA


ANNUAL MEETING BEGINS

OPENING SESSION | 5:00 pm - 7:10 pm | KEY BALLROOM

5:00 pm – 5:10 pm
SfRBM President's Welcome
Rick Domann Ph.D., The University of Iowa, USA, SfRBM President 

PLENARY SESSION
Translational Aspects of Redox Signaling
Chairs: Katrin Schröder, Ph.D., Goethe-University, Frankfurt am Main, Germany and Albert van der Vliet, Ph.D., University of Vermont, USA

ROS are important second messengers in cellular signaling and thereby play a crucial role in health and disease. Indeed specific redox modifications such as S-glutathionylation or other oxidative protein modifications have been shown to be related to cardiovascular or pulmonary diseases and successful translation of the knowledge derived from basic research to clinical or therapeutic applications will require a more complete understanding of specific redox events, and development of more selective approaches to target such specific events rather than generic antioxidant approaches which have had limited clinical application. This session will highlight some recent advances in this field and novel approaches to translate experimental findings into pharmacologic and clinical applications.

5:10 pm – 5:40 pm     
The Regulation of Nox in Vascular Disease
Francis Miller, MD, Duke University, USA

5:40 pm – 6:10 pm     
Redox Regulation of Kinases in the Heart
Friederike Cuello, Ph.D., University of Hamburg, Germany

6:10 pm – 6:40 pm     
Glutathione, Glutaredoxin and S-glutathionylation in Lung Disease
Yvonne Janssen-Heininger, Ph.D., University of Vermont, USA

6:40 pm – 7:10 pm     
SfRBM DISCOVERY AWARD LECTURE | KEY BALLROOM

7:15 pm – 8:30 pm     
WELCOME RECEPTION | BALLROOM FOYER

7:15 pm – 8:30 pm 
TRAINEE RECEPTION | BALLROOM FOYER

9:00 pm – 10:00 pm
HOSPITALITY 


THURSDAY, NOVEMBER 30, 2017

REGISTRATION/INFORMATION DESK
7:00 am - 6:30 pm  |  Key Ballroom Foyer

SUNRISE FREE RADICAL SCHOOL
Back to the Basics | 8:00 am – 9:00 am | KEY BALLROOM 
Chairs: Ralf Brandes, MD, Goethe-University, Frankfurt am Main, Germany and Jianhua Zhang, Ph.D., University of Alabama at Birmingham, USA

8:00 am – 8:30 am
Selenium in Biology and Medicine
Trent Tipple, MD, University of Alabama at Birmingham, USA

8:30 am – 9:00 am
Ferroptosis and Neurodegeneration
Qitao Ran, Ph.D., UTHSCSA, USA

PLENARY SESSION 1
9:30 am - 12:00 pm | KEY BALLROOM 
Selenium in Biology and Medicine: Celebrating the Discovery of Selenium by Jacob Berzelius and its Discovery in Biomolecules by Terry Stadtman
Chairs: Rodney Levine, NIH, MD, Ph.D., USA and Sue Goo Rhee, Ph.D., Yonsei University College of Medicine, South Korea

2017 is the 200th anniversary of the discovery of selenium by the Swedish chemist, Berzelius.  He recognized that this new element had properties similar to sulfur, even though it was a metal. The American biochemist Thressa Stadtman, who died last year, made major contributions to understanding selenium’s roles in biology and has been referred to as “The Mother of Selenium Biochemistry”.

9:30 am – 10:00 am   
Scientific Discoveries: Berzelius, Stadtman, and the Chemistry of Selenium
Buhm Soon Park, Ph.D., KAIST (Korea Advanced Institute of Science and Technology)/Harvard Kennedy School, USA

10:00 am – 10:30 am
How Selenocysteine Altered Our Understanding of Redox Biology
Vadim Gladyshev, Ph.D., Harvard Medical School, USA

10:30 am – 11:00 am | Break

11:00 am – 11:30 am
Selenium Status in Health & Disease
Margaret Rayman, DPhil, University of Surrey, UK 

11:30 am - 12:00 pm 
Differential Function of Catalase, Glutathione Peroxidase, and Peroxiredoxin in Mouse Red Blood Cells
Sue Goo Rhee, Ph.D.,Yonsei University College of Medicine, South Korea

PLENARY SESSION 2
9:30 am - 12:00 pm | KEY BALLROOM 

Ferroptosis: The Rancid Smell of Death
Chairs: Marcus Conrad, Ph.D., Helmholtz Zentrum Munchen, Germany and Maret Traber, Ph.D., Linus Pauling Institute, USA

Ferroptosis is a novel form or regulated necrotic cell death characterized by iron-dependent lipid peroxidation, which has attracted increased attention as a potential new anti-cancer strategy. With the identification of key enzymatic players, such as system Xc-, GPX4, ACSL4 and the micronutrient alpha-tocopherol, ferroptosis has been recognized to intersect at the cross-roads of cysteine/glutathione and polyunsaturated fatty acid metabolism. Therefore, it is now accepted that ferroptosis is not only an attractive anti-cancer strategy but that it is also implicated in a broad range of pathological conditions including neurodegeneration. With the advance of our knowledge on how to tip the ferroptosis scale, present and future research will provide insightful evidences on the beneficial effects of inducing or halting this form of cell death in defined pathological settings.

9:30 am – 10:00 am
Ferroptosis: Mechanisms and Therapeutic Applications
Brent Stockwell, Ph.D., Columbia University, USA

10:00 am – 10:30 am
Oxidation of Phosphatidylethanolamines as Ferroptotic Signals: Control by Lipoxygenases
Valerian Kagan, Ph.D., ScD, University of Pittsburgh, USA

10:30 am – 11:00 am | Break

11:00 am – 11:30 am 
Ferroptosis, Mechanism of Cell Death in Vitamin E Deficiency During Embryogenesis?
Maret Traber, Ph.D., Linus Pauling Institute, USA

11:30 am – 12:00 pm             
In Vivo Relevance of Ferroptotic Cell Death
Marcus Conrad, Ph.D., Helmholtz Zentrum Munchen, Germany

12:00 pm - 12:30 pm
SfRBM YEAR IN REVIEW: ANNUAL MEMBER MEETING | KEY BALLROOM 

12:30 pm – 2:30 pm | LUNCH 
Attendees on own or attend the professional development session

1:00 pm – 2:15 pm
PROFESSIONAL DEVELOPMENT SESSION I
Speed Mentoring: An opportunity to gather career advice from numerous attendees/mentors with a variety of backgrounds. 

1:00 pm – 2:15 pm
PROFESSIONAL DEVELOPMENT SESSION II 
Visual Arts: Learn to enhance your manuscript figures and online presence. 

2:30 pm – 4:15 pm
ORAL PRESENTATIONS FROM SUBMITTED ABSTRACTS | KEY BALLROOMS
3 concurrent sessions

4:15 pm – 6:45 pm
FORMAL POSTER PRESENTATIONS | KEY BALLROOMS

6:45 pm – 9:00 pm
OPENING DOORS EVENT 
Who is the Indiana Jones of Your Team?
Organized by Nukhet Aykin-Burns, Ph.D., University of Arkansas for Medical Sciences, USA, Maria Clara Franco, Ph.D., University of Central Florida, USA, Samantha Giordano, Ph.D., University of Alabama at Birmingham, USA, and Azza El-Remessy, Ph.D.,RPh, FAHA, University of Georgia, USA, and the Women in Science Committee (WIS)

The event will focus on how to manage personnel, time, money and stress at every stage of a researcher’s career. 

9:00 pm – 10:00 pm
HOSPITALITY


FRIDAY, DECEMBER 1, 2017

REGISTRATION/INFORMATION DESK
7:00 am - 6:30 pm  |  Key Ballroom Foyer

SUNRISE FREE RADICAL SCHOOL
Back to the Basics | 8:00 am – 9:00 am | KEY BALLROOM 
Chairs: Ralf Brandes, MD, Goethe-University, Frankfurt am Main, Germany and Jianhua Zhang, Ph.D., University of Alabama at Birmingham, USA

8:00 am – 8:30 am
ROS and Calcium
Indu Ambudkar, Ph.D., NIH, USA

8:30 am – 9:00 am
PRDX1 Redox Signaling in Cancer
Carola Neumann, MD, University of Pittsburgh, USA

PLENARY SESSION 1
9:30 am - 12:00 pm | KEY BALLROOM 
Redox Control of Calcium Homeostasis in Health and Disease
Chairs: Nadine Hempel, Ph.D., Penn State University College of Medicine, USA and Andre Melendez, Ph.D., SUNY Polytechnic Institute, USA

The regulation of calcium gradients across membranes and organelles is essential to cellular function. Plasma membrane and intracellular ion channels, such as those of the ER and mitochondria, are tightly regulated in a spatial and temporal manner by a variety of stimuli, including the emerging role of redox-dependent regulation. This plenary session focuses on the interplay between redox and Calcium-regulated cellular signaling pathways in normal and pathophysiological conditions.

9:30 am – 10:00 am
CaMKII, ROS and Fight or Flight Physiology
Mark Anderson, MD, Ph.D., Johns Hopkins University School of Medicine, USA

10:00 am – 10:30 am 
Mitochondrial-ER Ca2+ ROS Cross Talk
Gyorgy  Hajnóczky MD, Ph.D., Thomas Jefferson University, USA

10:30 am – 11:00 am | Break

11:00 am – 11:30 am
Role of the Ca2+ Channel TRPM2 in Regulation of Oxidative Stress and Energy Balance
Barbara Miller, MD, Penn State Hershey Children’s Hospital, USA

11:30 am - 12:00 pm 
Redox Regulation of Store Operated Calcium Entry via STIM and Orai
Ivan Bogeski, MD, Saarland University, Germany

PLENARY SESSION 2 
9:30 am - 12:00 pm | KEY BALLROOM 
Redox Biology of Normal vs Tumor Cells: A Therapeutic Target 
Chairs:  Ines Batinic-Haberle, Ph.D., Duke University, USA and Margaret Tome, Ph.D., University of Arizona, USA

In general, cancer cells have shifted to a pro-oxidative state with altered energy metabolism, chronic elevation of ROS production and an imbalance in the antioxidant response. Therapeutic strategies (drugs/radiation) that increase oxidative stress enhance tumor cell death; however, the adverse effect on normal tissues is often dose limiting. This session focuses on recent findings indicating that redox active therapeutics can differentially, and to our advantage, target cancer cells while sparing or protecting normal cells; possible mechanisms will be discussed.

9:30 am – 10:00 am
Therapeutic Potential of Metabolic Inhibition Combined with ROS Modulation
Douglas Spitz, Ph.D., The University of Iowa, USA

10:00 am – 10:30 am
Protection of Normal Hematopoietic Stem Cells During the Treatment of Hematopoietic Malignancies
Daret St. Clair, Ph.D., University of Kentucky, USA

10:30 am – 11:00 am | Break

11:00 am – 11:30 am
Use of Manganese Porphyrins as a Chemotherapeutic in Lymphoma
Margaret Tome, Ph.D., University of Arizona, USA

11:30 am – 12:00 pm 
Protection of Neurocognitive Function During Cranial Irradiation of Brain Tumors
Ting-Ting Huang, Ph.D., Stanford University & VA Palo Alto HSC, USA 

12:00 pm – 2:30 pm | LUNCH 
Attendees on own or attend a professional development session

1:00 pm – 2:15 pm
PROFESSIONAL DEVELOPMENT SESSION III
How to Deal with Failure?: As scientist we face constant struggles including grant and paper rejections, failed hypotheses, and maybe the threat of not making tenure. We will brain storm methods on how to deal with real challenges in the academic world and how not loose hope!

1:00 pm – 2:15 pm
PROFESSIONAL DEVELOPMENT SESSION IV  organized by the SfRBM Trainee Council
Science Policy: Discussion with an AAAS policy fellow. 

2:30 pm – 4:15 pm
ORAL PRESENTATIONS FROM SUBMITTED ABSTRACTS | KEY BALLROOMS
3 concurrent sessions

4:15 pm – 6:45 pm
FORMAL POSTER PRESENTATIONS | KEY BALLROOMS

6:00 pm – 6:30 pm 
FRBM EDITORS MEETING

6:30 pm – 7:00 pm 
REDOX BIOLOGY EDITORS MEETING

7:00 pm – 8:00 pm 
FRBM & REDOX BIOLOGY EDITORS RECEPTION 

9:00 pm – 10:00 pm
HOSPITALITY


SATURDAY, DECEMBER 2, 2017

REGISTRATION/INFORMATION DESK
7:00 am - 7:00 pm  |  Key Ballroom Foyer

SUNRISE FREE RADICAL SCHOOL | KEY BALLROOM
Back to the Basics | 8:00 am – 9:00 am 
Chairs: Ralf Brandes, MD, Goethe-University, Frankfurt am Main, Germany and Jianhua Zhang, Ph.D., University of Alabama at Birmingham, USA

8:00 am – 8:30 am
Mitochondrial Dynamics and Cardiac Mitochondrial Function
Asa Gustafsson, Ph.D., University of California, San Diego, USA

8:30 am – 9:00 am
Mitochondrial Metabolic Oscillations and Networks in Diabetes
Orian Shirihai, MD, Ph.D., Boston University, USA

PLENARY SESSION 
9:30 am - 12:00 pm | KEY BALLROOM
Mitochondrial Dynamics in Health and Disease
Chairs: Kimberly Dunham‐Snary, Ph.D., Queen’s University, Canada and Samantha Giordano, Ph.D., University of Alabama at Birmingham, USA

Mitochondrial dynamics (fission, fusion, and mitophagy) play a critical role in cellular homeostasis and redox regulation. Crosstalk between mitochondrial dynamics and reactive species production has become increasingly important in modulating cell survival and has been implicated in numerous pathologies including neurodegeneration, cardiovascular disease, and hyperproliferative diseases such as cancer. This session addresses the roles of mitochondrial fission, fusion, and mitophagy in cellular homeostasis during health and disease.   

9:30 am – 10:00 am   
Mitochondria, Mitophagy and Proteotoxicity in Relation to Parkinson’s Disease
Richard Youle, Ph.D., NINDS (National Institute of Neurological Disorders and Stroke), USA

10:00 am – 10:30 am
PINK1/Parkin and Mitochondrial Dynamics in Neurodegeneration
Ming Guo, MD, Ph.D., UCLA, USA 
                        
10:30 am – 11:00 am | Break

11:00 am – 11:30 am 
Mitochondrial Dynamics in Lung Fibrosis
A. Brent Carter, MD, University of Alabama at Birmingham, USA

11:30 am  - 12:00 pm     
Molecular Analysis of Mitochondrial Dynamics
David Chan, MD, Ph.D, Caltech, USA

12:00 pm – 12:30 pm
NEW MEMBER WELCOME MEETING 

1:00 pm – 2:30 pm | LUNCH
Attendees on own

2:30 pm – 4:15 pm
ORAL PRESENTATIONS FROM SUBMITTED ABSTRACTS | KEY BALLROOMS
3 concurrent sessions

4:15 pm – 7:00 pm
FORMAL POSTER PRESENTATIONS | KEY BALLROOM

7:30 pm – 9:30 pm
CLOSING AWARDS BANQUET | KEY BALLROOM

9:30 pm - 10:30 pm
HOSPITALITY 

SfRBM 2017 offically adjourns after the Closing Awards Banquet on Saturday, December 2. There will not be a Sunday Plenary Session.

updated 05/22/17